INT98310

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2001
Last Reported 2010
Negated 3
Speculated 5
Reported most in Body
Documents 21
Total Number 30
Disease Relevance 15.04
Pain Relevance 6.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
Anatomy Link Frequency
hippocampus 2
chondrocyte 1
tails 1
spinal cord 1
brain 1
gr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 123 100.00 Very High Very High Very High
antidepressant 19 100.00 Very High Very High Very High
antagonist 26 99.96 Very High Very High Very High
fluoxetine 16 99.84 Very High Very High Very High
Spinal cord 50 99.64 Very High Very High Very High
Hippocampus 45 99.18 Very High Very High Very High
Inflammation 314 99.16 Very High Very High Very High
depression 38 99.08 Very High Very High Very High
Clonidine 3 98.82 Very High Very High Very High
Morphine 365 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Chronic Obstructive Pulmonary Disease 540 100.00 Very High Very High Very High
Stress 183 100.00 Very High Very High Very High
INFLAMMATION 453 99.98 Very High Very High Very High
Hypertrophy 9 99.36 Very High Very High Very High
Disease 185 99.32 Very High Very High Very High
Stroke 54 99.12 Very High Very High Very High
Depression 36 99.08 Very High Very High Very High
Apoptosis 96 98.48 Very High Very High Very High
Urological Neuroanatomy 12 97.84 Very High Very High Very High
Drug Dependence 27 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to investigate effects of some classical and new antidepressants on functional activity of the glucocorticoid receceptor (GR) induced by low corticosterone concentration in mouse fibroblast cells stably transfected with mouse mammary tumor virus-chloramphenicol acetyltransferase plasmid (LMCAT cells).
Spec (investigate) Regulation (effects) of GR in fibroblast associated with antidepressant and cancer
1) Confidence 0.39 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18441395 Disease Relevance 0.10 Pain Relevance 0.20
may affect the function of HPA axis and/or GR and thus may contribute to the abnormal sensitivity to stressful situations in the GSK-3?
Spec (may) Regulation (affect) of GR
2) Confidence 0.34 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.46 Pain Relevance 0.27
Both hippocampal cell proliferation and BDNF mRNA expression were down-regulated in GR-i mice, and these alterations were reversed by chronic agomelatine and fluoxetine treatments, whereas GR mRNA down-regulation was reversed only by agomelatine.
Regulation (regulated) of GR associated with fluoxetine
3) Confidence 0.31 Published 2010 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19775499 Disease Relevance 0.38 Pain Relevance 0.73
We found no significant changes in GR and K values between this final and initial measure.
Neg (no) Regulation (changes) of GR
4) Confidence 0.26 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2904341 Disease Relevance 0.19 Pain Relevance 0.10
The influence of GR blockade on locomotor stimulant effects of morphine and development of physical dependence was evaluated in the C57BL/6J strain.
Regulation (influence) of GR associated with physical dependence, sprains and strains and morphine
5) Confidence 0.25 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.19 Pain Relevance 0.98
One candidate molecule is the anti-apoptotic co-chaperone BAG-1 which together with the chaperone HSP-70 is involved in regulation of GR binding activity [21].
Regulation (regulation) of GR associated with apoptosis
6) Confidence 0.21 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.25 Pain Relevance 0.15
Our pharmacological dissection of drug-regulated gene expression profiles showed the inhibitory effects of CRFR1 and GR antagonists on ethanol-activated gene expression of the B2 and B3 subclusters.
Regulation (effects) of GR associated with antagonist
7) Confidence 0.19 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.06 Pain Relevance 0.41
The changes in GR after 2 weeks of CS and AT seem to be a nonspecific response.
Regulation (changes) of GR
8) Confidence 0.18 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.43 Pain Relevance 0.03
There were no differences for GR and ?
Neg (no) Regulation (differences) of GR
9) Confidence 0.17 Published 2007 Journal Malar J Section Body Doc Link PMC1864988 Disease Relevance 0.05 Pain Relevance 0
The administration of the GR antisense oligodeoxynucleotide also prevented GR up-regulation within the spinal cord dorsal horn.
Regulation (regulation) of GR in spinal cord dorsal horn
10) Confidence 0.16 Published 2005 Journal Anesthesiology Section Body Doc Link 15791114 Disease Relevance 0 Pain Relevance 0
Our further literature search yielded data that implicate the glucocorticoid receptor (GR) as a potential modulator of Tsc22d3 transcription [17].
Spec (implicate) Regulation (implicate) of GR
11) Confidence 0.15 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.63 Pain Relevance 0.34
In ovarian cancer, GR was 75% and was not influenced by the quantity of the pretreatment daily fluid production.
Neg (not) Regulation (influenced) of GR
12) Confidence 0.14 Published 2001 Journal Oncology Section Body Doc Link 11574774 Disease Relevance 0 Pain Relevance 0
Tissue-specific first exon usage may contribute to the differential regulation of GR by fluoxetine in brain subregions.
Regulation (regulation) of GR in brain associated with fluoxetine
13) Confidence 0.13 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15469896 Disease Relevance 0 Pain Relevance 0.46
Several genes that depend on GR to be induced by LPS play important roles in terms of cell differentiation, acute phase response, extracellular matrix organization and interferon response, all of which potentially helping to resolve inflammation rapidly.
Regulation (depend) of GR in extracellular matrix associated with acute-phase reaction and inflammation
14) Confidence 0.13 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.90 Pain Relevance 0.37
Figure 5 shows the tizanidine effects on GR for all spinal cord injured individuals.
Regulation (effects) of GR in spinal cord associated with spinal cord
15) Confidence 0.11 Published 2010 Journal J Neuroeng Rehabil Section Body Doc Link PMC2904341 Disease Relevance 0 Pain Relevance 0.14
We identified the GR as a candidate for the regulation of chondrocyte hypertrophy in a previous expression profiling screen using primary micromass cultures [50].
Regulation (regulation) of GR in chondrocyte associated with hypertrophy
16) Confidence 0.11 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0.27 Pain Relevance 0.23
Therefore, in the present study we investigated the effect of prenatal stress on behavioral changes, blood corticosterone level, concentrations of glucocorticoid receptor (GR) and its cochaperone, FKBP51, in the hippocampus and frontal cortex in adult rats.
Spec (investigated) Regulation (effect) of GR in frontal cortex associated with stress, urological neuroanatomy and hippocampus
17) Confidence 0.07 Published 2009 Journal Psychoneuroendocrinology Section Abstract Doc Link 19195790 Disease Relevance 0.86 Pain Relevance 0.21
Our results reveal that TgNTRK3 mice exhibit an altered circadian corticosterone rhythm that is reversed by clonidine treatment, but normal expression of genes involved in the control of the hypothalamus-pituitary-adrenal (HPA) axis (CRH, GR) and normal corticosterone response to acute and chronic stressors.
Regulation (control) of GR in pituitary associated with clonidine
18) Confidence 0.06 Published 2010 Journal J Psychiatr Res Section Abstract Doc Link 19698958 Disease Relevance 1.23 Pain Relevance 0.14
function is the recruitment of corepressor complexes containing histone deacetylases (HDACs), which remove acetyl groups from the NH-terminal tails of core histone proteins.73–75 These acetyl groups on the histone tails confer a “relaxed” transcriptionally open structure to the promoter region of the genes, and their removal results in reassociation of the DNA around the core histones and gene silencing.73,74,76 In vitro studies using small interfering RNA and overexpression models have shown that HDAC-2 is the key in the functional mechanism of GC-mediated or GR?
Regulation (recruitment) of GR in tails
19) Confidence 0.06 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.59 Pain Relevance 0.05
affects HDAC-2 activity and GR?
Regulation (affects) of GR
20) Confidence 0.06 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.75 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox