INT9832

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Context Info
Confidence 0.75
First Reported 1982
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 96
Total Number 101
Disease Relevance 56.71
Pain Relevance 12.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Shbg) extracellular region (Shbg)
Anatomy Link Frequency
liver 7
blood 7
Plasma 5
heart 3
spikes 1
Shbg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dismenorea 31 100.00 Very High Very High Very High
headache 328 99.92 Very High Very High Very High
Neurotransmitter 4 99.80 Very High Very High Very High
transcutaneous nerve stimulation 1 99.78 Very High Very High Very High
Periaqueductal grey 6 99.68 Very High Very High Very High
Serotonin 10 99.64 Very High Very High Very High
narcan 21 99.56 Very High Very High Very High
transdermal 138 99.38 Very High Very High Very High
backache 5 98.88 Very High Very High Very High
opiate 7 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 1673 100.00 Very High Very High Very High
Diabetes Mellitus 537 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 326 100.00 Very High Very High Very High
Peritonitis 257 100.00 Very High Very High Very High
Reprotox - General 1 199 100.00 Very High Very High Very High
Reprotox - General 2 40 100.00 Very High Very High Very High
Insulin Resistance 29 100.00 Very High Very High Very High
Bradycardia 19 100.00 Very High Very High Very High
Headache 438 99.92 Very High Very High Very High
Acute Coronary Syndrome 9 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma testosterone, unbound testosterone, Sex Hormone Binding Globulin (SHBG) and albumin were studied in women with 'non-endocrine' ovarian carcinoma prior to and during chemotherapy.
Gene_expression (studied) of SHBG in Plasma associated with ovarian cancer
1) Confidence 0.75 Published 1986 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 3799148 Disease Relevance 0.34 Pain Relevance 0.07
Plasma testosterone, unbound testosterone, Sex Hormone Binding Globulin (SHBG) and albumin were studied in women with 'non-endocrine' ovarian carcinoma prior to and during chemotherapy.
Gene_expression (studied) of Sex Hormone Binding Globulin in Plasma associated with ovarian cancer
2) Confidence 0.75 Published 1986 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 3799148 Disease Relevance 0.34 Pain Relevance 0.07
Hence they should be performed routinely for early detection of SBP.
Gene_expression (detection) of SBP associated with peritonitis
3) Confidence 0.70 Published 1992 Journal J Assoc Physicians India Section Abstract Doc Link 1452529 Disease Relevance 1.10 Pain Relevance 0.08
The synaptic vesicle protein synaptophysin and a 45 kDa protein found specifically in serotonergic synaptic vesicles, serotonin-binding protein (SBP), were each enriched in IGC fractions from E15 to postnatal day 5; SBP immunoreactivity increased approximately 10-fold between E15 and E20.
Gene_expression (enriched) of SBP in synaptic vesicle associated with serotonin
4) Confidence 0.63 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7509861 Disease Relevance 0 Pain Relevance 0.24
With respect to the other steroids measured, as well as SHBG, no differences between PMS subjects and controls were found.
Gene_expression (found) of SHBG associated with dismenorea
5) Confidence 0.62 Published 1992 Journal Psychoneuroendocrinology Section Abstract Doc Link 1438645 Disease Relevance 0.46 Pain Relevance 0.46
In the presence of atenolol 2 mg kg(-1) h(-1), clonidine 10-100 microg kg(-1) i.v. evoked a significant reduction in SBP, a large increase of CVM firing rate from a very low base line [0.16 (sd 0.28) to 1.37 (1.21) spikes s(-1), n=7 cells], and increased the slope of the cardiac baroreflex analysed at the CVM level or at the heart level. sds of SBP were reduced, and that of RR interval was increased.
Gene_expression (reduction) of SBP in spikes
6) Confidence 0.59 Published 2009 Journal Br J Anaesth Section Body Doc Link 19189981 Disease Relevance 0.07 Pain Relevance 0
[Changes in plasma levels of androgens and SHBG in patients with polycystic ovary syndrome (PCOs) treated with oral contraceptives containing desogestrel].
Gene_expression ([Changes) of SHBG in plasma associated with polycystic ovary syndrome
7) Confidence 0.59 Published 1988 Journal Minerva Ginecol Section Title Doc Link 2977429 Disease Relevance 0.39 Pain Relevance 0
RESULTS: The trial was completed in 92% of the patients, 5 patients withdrew in the SBP group and 11 patients in the control group; but none for the intolerable therapy.
Gene_expression (group) of SBP
8) Confidence 0.58 Published 2008 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 18672763 Disease Relevance 0.14 Pain Relevance 0
Levels of sex hormone binding globulin (SHBG), a protein increased by EE to which NET binds, were also examined.
Spec (examined) Gene_expression (Levels) of SHBG
9) Confidence 0.58 Published 2000 Journal J Clin Pharmacol Section Abstract Doc Link 10709161 Disease Relevance 0.09 Pain Relevance 0.18
Levels of sex hormone binding globulin (SHBG), a protein increased by EE to which NET binds, were also examined.
Spec (examined) Gene_expression (Levels) of sex hormone binding globulin
10) Confidence 0.58 Published 2000 Journal J Clin Pharmacol Section Abstract Doc Link 10709161 Disease Relevance 0.09 Pain Relevance 0.18
METHODS: To evaluate the effect of preoperative systolic blood pressure (SBP) and plasma catecholamine levels on core temperature during general anesthesia, 40 male patients who were scheduled for open abdominal surgery were allocated to two groups: those whose preoperative SBP was 140 mmHg or greater (high SBP group, n = 20), and those whose SBP was less than 140 mmHg (normal SBP group, n = 20).
Gene_expression (preoperative) of SBP in blood
11) Confidence 0.57 Published 2003 Journal Acta Anaesthesiol Scand Section Body Doc Link 12631051 Disease Relevance 0.09 Pain Relevance 0
Nevertheless, recent studies tend to demonstrate that SBP incidence seems to be decreasing (Sette et al 1986).
Gene_expression (incidence) of SBP associated with peritonitis
12) Confidence 0.54 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621420 Disease Relevance 1.44 Pain Relevance 0.03
Kim and colleagues (2005) studied the use of two brands of reagent strips, Uriscan (BioSys Laboratories, La Canada, CA, USA) and Multistix 10SG for SBP diagnosis and found different results in sensibility and specificity.
Gene_expression (diagnosis) of SBP associated with peritonitis
13) Confidence 0.54 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621420 Disease Relevance 0.19 Pain Relevance 0
activation with the anti-diabetic drug rosiglitazone and male sex hormone profile under diabetic conditions.
Gene_expression (profile) of sex hormone associated with diabetes mellitus
14) Confidence 0.52 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696180 Disease Relevance 0.87 Pain Relevance 0.04
An IV test dose produced significant increases in HR and SBP and decreases in T-wave amplitude in all subjects.
Gene_expression (produced) of SBP
15) Confidence 0.51 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11726454 Disease Relevance 0.07 Pain Relevance 0.32
In terms of hormone and bone biomarkers, the European trial showed a significant decrease in FSH and estradiol levels in postmenopausal women, and a significant increase in SHBG levels for both arzoxifene doses, with a significant decrease in LH levels for the 50 mg/day dose only (Baselga et al. 2003), although there was no significant difference between the two dosages.
Gene_expression (levels) of SHBG
16) Confidence 0.50 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012444 Disease Relevance 0.21 Pain Relevance 0
A low SHBG concentration is considered a risk factor for type 2 diabetes and a direct correlation between insulin sensitivity and SHBG has previously been demonstrated [18,19].
Gene_expression (sensitivity) of SHBG associated with diabetes mellitus
17) Confidence 0.49 Published 2003 Journal BMC Fam Pract Section Body Doc Link PMC165418 Disease Relevance 0.19 Pain Relevance 0
At the same timepoints blood samples were drawn for the following analyses: blood glucose, GHbA1c, serum cholesterol, serum HDL-cholesterol, serum triglycerides, free fatty acids (FFA), serum cortisol, sex hormone binding globulin (SHBG), and serum leptin.
Spec (analyses) Gene_expression (drawn) of SHBG in blood associated with disorder of lipid metabolism
18) Confidence 0.49 Published 2003 Journal BMC Fam Pract Section Body Doc Link PMC165418 Disease Relevance 0.63 Pain Relevance 0.06
In other words, low levels of SHBG are indicative of insulin resistance.
Gene_expression (resistance) of SHBG associated with insulin resistance
19) Confidence 0.49 Published 2003 Journal BMC Fam Pract Section Body Doc Link PMC165418 Disease Relevance 0.25 Pain Relevance 0
We studied prospectively 200 samples of ascitic fluid of 106 cirrhotic patients and detected SBP in 11% of the studied population in both inpatient and outpatient settings.
Gene_expression (detected) of SBP associated with cirrhosis and peritonitis
20) Confidence 0.49 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621420 Disease Relevance 1.34 Pain Relevance 0

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