INT98322

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.14
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Camk2g) kinase activity (Camk2g)
Anatomy Link Frequency
spinal cord 4
neurite 2
Camk2g (Mus musculus)
Pain Link Frequency Relevance Heat
Nicotine 12 98.58 Very High Very High Very High
Spinal cord 10 97.70 Very High Very High Very High
Calcium channel 2 96.56 Very High Very High Very High
antagonist 2 89.92 High High
tail-flick 6 86.76 High High
Antinociceptive 2 85.04 High High
antinociception 6 81.28 Quite High
lidocaine 3 50.00 Quite Low
Root ganglion neuron 2 50.00 Quite Low
analgesia 2 40.64 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 100.00 Very High Very High Very High
Ganglion Cysts 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Low-concentration lidocaine rapidly inhibits axonal transport and neurite growth via activation of calmodulin-dependent protein kinase II.


Negative_regulation (inhibits) of Positive_regulation (activation) of calmodulin-dependent protein kinase II in neurite
1) Confidence 0.43 Published 2001 Journal Anesthesiology Section Body Doc Link 11575541 Disease Relevance 0 Pain Relevance 0
When calcium/calmodulin-dependent calmodulin protein kinase II activity in the lumbar spinal cord after acute i.t. administration of nicotine was investigated in wild-type and beta2 and alpha7 knockout mice, the increase in calcium/calmodulin-dependent calmodulin protein kinase II activity was not significant reduced in alpha7 KO mice but was eliminated in the beta2 KO mice.
Negative_regulation (reduced) of Positive_regulation (increase) of calmodulin protein kinase II in spinal cord associated with targeted disruption, nicotine and spinal cord
2) Confidence 0.21 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17041007 Disease Relevance 0.57 Pain Relevance 0.85
When calcium/calmodulin-dependent calmodulin protein kinase II activity in the lumbar spinal cord after acute i.t. administration of nicotine was investigated in wild-type and beta2 and alpha7 knockout mice, the increase in calcium/calmodulin-dependent calmodulin protein kinase II activity was not significant reduced in alpha7 KO mice but was eliminated in the beta2 KO mice.
Negative_regulation (eliminated) of Positive_regulation (increase) of calmodulin protein kinase II in spinal cord associated with targeted disruption, nicotine and spinal cord
3) Confidence 0.21 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17041007 Disease Relevance 0.57 Pain Relevance 0.86

General Comments

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