INT98329

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 13.13
Pain Relevance 10.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX4) transport (P2RX4) plasma membrane (P2RX4)
response to stress (P2RX4)
Anatomy Link Frequency
microglial cells 10
macrophages 2
nerve 2
mast cell 2
alveolar macrophages 1
P2RX4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 62 99.76 Very High Very High Very High
Neuropathic pain 126 99.20 Very High Very High Very High
Inflammatory mediators 2 99.20 Very High Very High Very High
Peripheral nerve injury 18 99.14 Very High Very High Very High
Dorsal horn 50 98.64 Very High Very High Very High
Brush evoked pain 52 98.20 Very High Very High Very High
cytokine 31 96.68 Very High Very High Very High
adenocard 17 96.48 Very High Very High Very High
Morphine 206 96.32 Very High Very High Very High
Stimulus evoked pain 29 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 209 99.20 Very High Very High Very High
INFLAMMATION 34 99.20 Very High Very High Very High
Nervous System Injury 86 99.14 Very High Very High Very High
Apoptosis 16 97.44 Very High Very High Very High
Nociception 5 97.16 Very High Very High Very High
Hypersensitivity 38 95.96 Very High Very High Very High
Pain 131 95.28 Very High Very High Very High
Injury 28 94.64 High High
Hypertrophy 4 93.88 High High
Mycobacterial Infection 12 92.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Coexpression of P2X4S341W with P2X7 produced a current that was potentiated by ivermectin and inhibited by 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5-triphosphate (TNP-ATP), whereas expression of P2X7 alone produced a current that was insensitive to both of these compounds at the concentrations used.
Gene_expression (Coexpression) of P2X4 associated with adenocard
1) Confidence 0.75 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17785580 Disease Relevance 0.18 Pain Relevance 0.20
Although P2X7 receptors are frequently coexpressed with another subtype of P2X receptor, P2X4, they are believed not to form heteromeric assemblies but to function only as homomers.
Gene_expression (coexpressed) of P2X4
2) Confidence 0.73 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17785580 Disease Relevance 0.27 Pain Relevance 0.22
The expression of P2X4 receptor, a subtype of ATP receptors, is enhanced in spinal microglia after peripheral nerve injury model, and blocking pharmacologically and suppressing molecularly P2X4 receptors produce a reduction of the neuropathic pain.
Gene_expression (suppressing) of P2X4 in microglia associated with nervous system injury, neuropathic pain and peripheral nerve injury
3) Confidence 0.65 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16169595 Disease Relevance 1.61 Pain Relevance 1.25
The expression of P2X4 receptor, a subtype of ATP receptors, is enhanced in spinal microglia after peripheral nerve injury model, and blocking pharmacologically and suppressing molecularly P2X4 receptors produce a reduction of the neuropathic pain.
Gene_expression (produce) of P2X4 in microglia associated with nervous system injury, neuropathic pain and peripheral nerve injury
4) Confidence 0.65 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16169595 Disease Relevance 1.60 Pain Relevance 1.25
Coexpression of a dominant-negative P2X4 mutant (C353W) with P2X7, inhibited P2X7 receptor mediated currents by greater than 2-fold, whereas a nonfunctional but non-dominant-negative mutant (S341W) did not.
Gene_expression (Coexpression) of P2X4
5) Confidence 0.63 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17785580 Disease Relevance 0.21 Pain Relevance 0.21
We studied total and surface membrane P2X(4)R protein expression by Western blot and biotinylation assays and functional expression by whole-cell patch clamp assays in human and rat alveolar macrophages in response to phagocytosis of zymosan and opsonized zymosan bioparticles and to classical and alternative macrophage activation.
Gene_expression (expression) of P2X in alveolar macrophages
6) Confidence 0.61 Published 2009 Journal Eur. J. Immunol. Section Abstract Doc Link 19283779 Disease Relevance 0.18 Pain Relevance 0.09
In contrast, classical activation of macrophage for 48 h with IFN-gamma and TNF-alpha or IFN-gamma and LPS reduced surface and functional P2X(4)R expression by 3-fold without altering total P2X(4)R protein levels.
Gene_expression (expression) of P2X in macrophage
7) Confidence 0.61 Published 2009 Journal Eur. J. Immunol. Section Abstract Doc Link 19283779 Disease Relevance 0.12 Pain Relevance 0.06
Phagocytosis rapidly (within 4 h) increased functional P2X(4)R expression by 2- to 7-fold as did chloroquine, an agent known to induce lysosomal secretion.
Gene_expression (expression) of P2X
8) Confidence 0.61 Published 2009 Journal Eur. J. Immunol. Section Abstract Doc Link 19283779 Disease Relevance 0.14 Pain Relevance 0.07
Mast cell-derived tryptase activated PAR2 that resulted in promoting the expression of P2X4R in microglial cells.
Gene_expression (expression) of P2X4R in microglial cells
9) Confidence 0.49 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20025063 Disease Relevance 0.45 Pain Relevance 0.28
The present study aimed to elucidate the mechanism by which mast cell activation promoted the expression of P2X4R in the microglia.
Gene_expression (expression) of P2X4R in mast cell
10) Confidence 0.49 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20025063 Disease Relevance 0.54 Pain Relevance 0.31
Pretreatment with antibodies against tryptase or PAR2, or using tryptase-deficient HMC-1 cells or PAR2-deficient microglial cells abolished the increase in P2X4R expression and BDNF release.
Gene_expression (expression) of P2X4R in microglial cells
11) Confidence 0.49 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20025063 Disease Relevance 0.41 Pain Relevance 0.25
Increase in mitogen activated protein kinase phosphorylation was observed in the processes of mast cell-induced BDNF release and P2X4R expression.
Gene_expression (expression) of P2X4R in mast cell
12) Confidence 0.49 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20025063 Disease Relevance 0.37 Pain Relevance 0.23
The causative factors involving the P2X4R over expression in the microglia remains unclear.
Gene_expression (expression) of P2X4R in microglia
13) Confidence 0.49 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20025063 Disease Relevance 0.55 Pain Relevance 0.30
We conclude that mast cell activation has the capacity to promote the expression of P2X4R and BDNF in microglial cells.
Gene_expression (expression) of P2X4R in microglial cells
14) Confidence 0.49 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20025063 Disease Relevance 0.35 Pain Relevance 0.21
The results of present study showed that mast cell activation markedly promoted the expression of P2X4R and BDNF in microglial cells, which significantly enhanced the release of BDNF from microglial cells upon exposure to adenosine triphosphate.
Gene_expression (expression) of P2X4R in microglial cells associated with adenocard
15) Confidence 0.49 Published 2010 Journal J. Neurosci. Res. Section Abstract Doc Link 20025063 Disease Relevance 0.51 Pain Relevance 0.30
Alternative activation with IL-4 or IL-13 did not alter total, surface or functional expression of P2X(4)R.
Gene_expression (expression) of P2X
16) Confidence 0.47 Published 2009 Journal Eur. J. Immunol. Section Abstract Doc Link 19283779 Disease Relevance 0.11 Pain Relevance 0.06
The expression of P2X4R protein, normally low in the naïve spinal cord, progressively increased in the days following nerve injury with a time-course parallel to that of the development of tactile allodynia.
Gene_expression (expression) of P2X4R in nerve associated with brush evoked pain, nervous system injury and spinal cord
17) Confidence 0.45 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 1.31 Pain Relevance 1.15
The cells expressing P2X4R in the nerve-injured side of the dorsal horn were more numerous than under control conditions and showed high levels of OX42 labeling and morphological hypertrophy, all of which are characteristic markers of activated microglia.
Gene_expression (expressing) of P2X4R in microglia associated with hypertrophy and dorsal horn
18) Confidence 0.45 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 1.21 Pain Relevance 0.88
These activated microglia express P2X4R; endogenous ATP can then activate these receptors and lead to neuropathic pain.
Gene_expression (express) of P2X4R in microglia associated with neuropathic pain
19) Confidence 0.45 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096535 Disease Relevance 0.65 Pain Relevance 0.81
P2X(3) is a novel ATP-gated cation channel that is selectively expressed by small-diameter sensory neurones in rodents, and may play a role in nociception by binding ATP released from damaged or inflamed tissues.
Gene_expression (expressed) of ATP-gated associated with nociception
20) Confidence 0.38 Published 2001 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 11576396 Disease Relevance 0.26 Pain Relevance 0.08

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