INT9835

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Context Info
Confidence 0.47
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 6.76
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (AICDA) cytoplasm (AICDA)
Anatomy Link Frequency
grid 1
brain 1
platelets 1
AICDA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 15 98.32 Very High Very High Very High
spinal inflammation 32 98.16 Very High Very High Very High
psoriasis 4 87.84 High High
rheumatoid arthritis 28 87.60 High High
anesthesia 19 82.36 Quite High
peptic ulcer disease 1 81.08 Quite High
headache 1 80.76 Quite High
imagery 1 66.64 Quite High
Multiple sclerosis 48 59.12 Quite High
Opioid 1 9.12 Low Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 180 100.00 Very High Very High Very High
Disease 95 99.60 Very High Very High Very High
Shock 19 99.24 Very High Very High Very High
Rheumatoid Arthritis 123 98.82 Very High Very High Very High
Mixed Conductive-sensorineural Hearing Loss 2 98.60 Very High Very High Very High
Low Back Pain 33 98.16 Very High Very High Very High
Systemic Lupus Erythematosus 24 98.12 Very High Very High Very High
Adhesions 8 97.72 Very High Very High Very High
Convulsion 38 96.92 Very High Very High Very High
Diabetes Mellitus 68 91.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vinculin dephosphorylation disturbs the interaction and recruitment of the actin-related protein 2/3 (Arp2/3) complex by p34Arc, resulting in a reduction of focal adhesion complexes.
Arp2 Binding (interaction) of associated with adhesions
1) Confidence 0.47 Published 2007 Journal Cell. Microbiol. Section Abstract Doc Link 17217431 Disease Relevance 0.98 Pain Relevance 0.08
However, cortactin has 6.5 F-actin binding repeats [8], whereas HS1 only has 3.5 and this changes the way in which the protein interacts with Arp2/3-induced F-actin arrays [10].
Arp2 Binding (interacts) of
2) Confidence 0.36 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.06 Pain Relevance 0
Together these data indicate that, in platelets, the re-organization of F-actin and Arp2/3 complex which underpins cell spreading does not require the activity of HS1.
Arp2 Binding (organization) of in platelets
3) Confidence 0.36 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.35 Pain Relevance 0
In conclusion, speech recognition with the BAHA HC220 in the patients with severe mixed hearing loss was comparable to, or better than, that with a CBHA.
BAHA Binding (recognition) of associated with mixed conductive-sensorineural hearing loss
4) Confidence 0.35 Published 1992 Journal Scand Audiol Section Abstract Doc Link 1439502 Disease Relevance 0.32 Pain Relevance 0.08
Overlap between HLA class II associations has been seen between AIDs, with DR3 also being associated with GD, SLE and HT, therefore, being termed the ‘autoimmunity haplotype’ (See Table 1 for list of common AID HLA class II associations).
AID Binding (associations) of associated with autoimmune disease, systemic lupus erythematosus and disease
5) Confidence 0.08 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 1.17 Pain Relevance 0.04
Although this review has focused on the classical HLA class I and II associations which have shown strong and consistent association with AID, several other genes within the HLA region may be acting as independent risk factors for AID (Table 3).
AID Binding (association) of associated with autoimmune disease
6) Confidence 0.08 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 0.57 Pain Relevance 0.04
Although other components of the HLA class I and III regions have also been investigated for association with AID, apart from the association of HLA-B*27 with ankylosing spondylitis, it has been difficult to determine additional susceptibility loci independent of the strong linkage disequilibrium (LD) with the HLA class II genes.
AID Binding (association) of associated with spinal inflammation and autoimmune disease
7) Confidence 0.08 Published 2007 Journal Current Genomics Section Abstract Doc Link PMC2647156 Disease Relevance 1.17 Pain Relevance 0.17
Statistical modelling techniques, including logistic regression analysis, have been employed to determine which components of the DRB1-DQB1-DQA1 haplotype contain the etiological variants associated with AID.
AID Binding (associated) of associated with autoimmune disease
8) Confidence 0.08 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 1.27 Pain Relevance 0.06
1 subunit alpha interaction domain (AID) and contains residues known to bind the calcium channel ?
AID Binding (interaction) of associated with calcium channel
9) Confidence 0.07 Published 2010 Journal Mol Brain Section Body Doc Link PMC2829547 Disease Relevance 0 Pain Relevance 0.08
On each day, the subject was instructed to stand upright, first on the ground and then on the BalancAid.
BalancAid Binding (ground) of
10) Confidence 0.07 Published 2010 Journal Ann Biomed Eng Section Body Doc Link PMC2940050 Disease Relevance 0 Pain Relevance 0.03
The simple models shown in the figure suggest that the brain's capacity to generate integrated information would collapse also when the great majority of neurons were firing simultaneously.
integrated Binding (generate) of in brain associated with shock
11) Confidence 0.02 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0.28 Pain Relevance 0.08
The state depicted in Figure 17C is a near-tense state, differing from a tense state in a single element, and thus generates a large amount of integrated information.


integrated Binding (amount) of
12) Confidence 0.02 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
The graph shows average integrated information, averaged over all output states (that can arise from the dynamics of the system) with the given firing rate.

?

integrated Binding (averaged) of
13) Confidence 0.02 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
The graph shows average integrated information, averaged over all output states (that can arise from the dynamics of the system) with the given firing rate.

?

integrated Binding (average) of
14) Confidence 0.02 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
We introduce a measure that quantifies how much integrated information is generated by a discrete dynamical system in the process of transitioning from one state to the next.
integrated Binding (generated) of
15) Confidence 0.02 Published 2008 Journal PLoS Computational Biology Section Abstract Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
Finding the integrated information generated by a physical system requires analyzing it from the ground up, without preconception regarding the nature of its elementary units.
integrated Binding (Finding) of
16) Confidence 0.02 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
It proceeds by defining integrated information and suggesting how it can be measured for stationary systems.
integrated Binding (defining) of
17) Confidence 0.02 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0.07 Pain Relevance 0
We have suggested that consciousness has to do with a system's capacity to generate integrated information.
integrated Binding (generate) of
18) Confidence 0.02 Published 2008 Journal PLoS Computational Biology Section Abstract Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
Why do attractors and their neighbors generate low integrated information?
integrated Binding (generate) of
19) Confidence 0.02 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
However the networks are diagonal sections of a grid, and so are similarly inefficient at generating integrated information.
integrated Binding (generating) of in grid
20) Confidence 0.02 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0

General Comments

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