INT98357

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 1.87
Pain Relevance 4.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gnas) endosome (Gnas) signal transduction (Gnas)
extracellular region (Gnas) plasma membrane (Gnas) GTPase activity (Gnas)
Anatomy Link Frequency
spinal cord 2
IB4 1
heart 1
SH3 1
Gnas (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 13 100.00 Very High Very High Very High
Kinase C 12 100.00 Very High Very High Very High
narcan 3 100.00 Very High Very High Very High
nociceptor 1 99.60 Very High Very High Very High
agonist 13 99.16 Very High Very High Very High
Morphine 10 99.16 Very High Very High Very High
spastic colon 3 99.12 Very High Very High Very High
withdrawal 5 98.80 Very High Very High Very High
Kappa opioid receptor 2 98.16 Very High Very High Very High
Enkephalin 6 97.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 6 100.00 Very High Very High Very High
Nociception 2 99.40 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

3 99.12 Very High Very High Very High
Lordosis 2 96.32 Very High Very High Very High
Functional Bowel Disorder 1 94.20 High High
Targeted Disruption 6 78.88 Quite High
Age-related Macular Degeneration 246 78.72 Quite High
Lung Cancer 3 75.56 Quite High
Colon Cancer 4 74.32 Quite High
Dna Damage 16 70.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our aim was to evaluate the association between GSA, GI symptom severity, and QOL in IBS patients.
GSA Binding (association) of associated with spastic colon and anxiety disorder
1) Confidence 0.41 Published 2010 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 20367800 Disease Relevance 0.45 Pain Relevance 0.29
GSA was then used to test the association of the DNA damage to predefined gene sets.
GSA Binding (association) of
2) Confidence 0.04 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2799513 Disease Relevance 0.19 Pain Relevance 0
On the other hand, the delta-opioid receptor agonist [D-Pen (2,5)]enkephalin, the kappa-opioid receptor agonist (-)U50,488H, or the ORL1-receptor agonist nociception increased [(35)S]GTP gamma S binding in the spinal cord membranes from both MOR (Exon 1)-KO mice and MOR (Exons 2 and 3)-KO mice to the same extent as in the corresponding wild-type mice.
Exon Binding (binding) of in spinal cord associated with nociception, kappa opioid receptor, agonist, enkephalin, opioid receptor and spinal cord
3) Confidence 0.02 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14737012 Disease Relevance 0.17 Pain Relevance 1.23
The mu-opioid receptor agonists (D-Ala(2),N-MePhe (4),Gly-ol(5)]enkephalin, endomorphin-1, endomorphin-2, morphine, morphine-6 beta-glucuronide, and fentanyl produced concentration-dependent increases of [(35)S]GTP gamma S binding to spinal cord membranes in wild-type mice, but not in MOR (Exon 1)-KO mice or MOR (Exons 2 and 3)-KO mice.
Exon Binding (binding) of in spinal cord associated with agonist, enkephalin, opioid receptor, spinal cord and morphine
4) Confidence 0.02 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14737012 Disease Relevance 0.16 Pain Relevance 1.23
Our preliminary screening of protein candidates that interact with the exon 22-encoded region, by yeast two-hybrid, isolated five candidates; however, none of these had an SH3 domain (data not shown).
exon Binding (interact) of in SH3
5) Confidence 0.01 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1853102 Disease Relevance 0 Pain Relevance 0
The spliceosome is a large complex of small nuclear ribonucleoprotein particles (snRNPs) that assemble onto splice sites to bring the intron ends into juxtaposition, and catalyze intron excision and exon ligation [11].
exon Binding (ligation) of
6) Confidence 0.01 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1790950 Disease Relevance 0 Pain Relevance 0.04
If alternate transcription start sites are used, the splicing machinery would still need to be different in order for the transcription complex to recognize the different exon 8 splice sites.
exon Binding (recognize) of
7) Confidence 0.00 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0.03
In particular, whether or not an agent binds one or all VEGF-A isoforms appears to have a substantial impact on efficacy.
isoforms Binding (binds) of
8) Confidence 0.00 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012443 Disease Relevance 0.53 Pain Relevance 0
However, weak VGLUT2 immunoreactivity was detectable in primary sensory nociceptors expressing lectin (GSA-IB4) binding and in 83-90% of C(I) glomerular terminals in LII.
GSA-IB4 Binding (binding) of in IB4 associated with nociceptor
9) Confidence 0.00 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 15065123 Disease Relevance 0 Pain Relevance 0.26
Alterations in protein kinase A and different protein kinase C isoforms in the heart during morphine withdrawal.
isoforms Binding (Alterations) of in heart associated with kinase c, narcan, withdrawal and morphine
10) Confidence 0.00 Published 2005 Journal Eur. J. Pharmacol. Section Title Doc Link 16202991 Disease Relevance 0 Pain Relevance 1.28
We have examined the effect of multiple ligand-binding TR isoforms on the ER-mediated induction of the PPE gene in transient transfection assays in CV-1 cells.
isoforms Spec (examined) Binding (binding) of
11) Confidence 0.00 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11578528 Disease Relevance 0.10 Pain Relevance 0
This is the first study revealing specific interactions among nuclear receptor isoforms on a neuroendocrine promoter.
isoforms Binding (interactions) of
12) Confidence 0.00 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11578528 Disease Relevance 0 Pain Relevance 0

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