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Context Info
Confidence 0.29
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
pseudotumor 2
spermatids 2
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 5 98.54 Very High Very High Very High
dysesthesia 3 92.96 High High
ischemia 16 83.60 Quite High
rheumatoid arthritis 2 75.00 Quite High
diabetic neuropathy 1 74.56 Quite High
Pain 2 64.36 Quite High
qutenza 8 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 5 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dysesthesia 3 92.96 High High
Diabetes Mellitus 1 84.92 Quite High
Cv Unclassified Under Development 14 83.60 Quite High
Abnormal Reflex 1 75.84 Quite High
Rheumatoid Arthritis 2 75.00 Quite High
Hypoxia 146 73.88 Quite High
Hypesthesia 2 72.32 Quite High
Emaciation 1 70.68 Quite High
Pain 2 64.36 Quite High
Acidosis 3 15.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
expression in the Leydig cells and elongating spermatids of adult mice [24], others reporting a developmental decline in ER?
Negative_regulation (reporting) of Negative_regulation (decline) of ER in spermatids
1) Confidence 0.29 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
Methotrexate (MTX) at a dose of 5mg/week was started in February 1991 and the pseudotumor decreased in size with a concurrent reduction of ESR, RF and CRP.
Negative_regulation (decreased) of Negative_regulation (reduction) of ESR in pseudotumor associated with methotrexate
2) Confidence 0.04 Published 1992 Journal Ryumachi Section Abstract Doc Link 1440085 Disease Relevance 0.73 Pain Relevance 0.58
15 min in anoxic aglycemia), profound disturbance of Ca2+ homeostasis with near complete failure of Ca2+ clearance by both SERCA and PMCA and complete depletion of the ER Ca2+ stores.
Negative_regulation (failure) of Negative_regulation (depletion) of ER
3) Confidence 0.03 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.22 Pain Relevance 0.04

General Comments

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