INT98376

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Context Info
Confidence 0.51
First Reported 2001
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 21.90
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 3
Atlas 2
visceral 1
ACN 1
dendritic cells 1
tk (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 44 100.00 Very High Very High Very High
imagery 247 99.28 Very High Very High Very High
Inflammation 150 96.84 Very High Very High Very High
nud 1 95.40 Very High Very High Very High
agonist 42 94.52 High High
positron emission tomography 26 93.52 High High
opioid receptor 1 87.20 High High
Kinase C 3 83.44 Quite High
Central nervous system 29 82.36 Quite High
Opioid 1 80.04 Quite High
Disease Link Frequency Relevance Heat
Cold Sores 47 100.00 Very High Very High Very High
Fibromyalgia 33 100.00 Very High Very High Very High
Herpes Simplex Virus 16 100.00 Very High Very High Very High
Influenza Virus Infection 8 100.00 Very High Very High Very High
Sprains And Strains 461 99.98 Very High Very High Very High
Cancer 2420 99.92 Very High Very High Very High
Mycobacterial Infection 588 99.86 Very High Very High Very High
Malignant Neoplastic Disease 29 99.84 Very High Very High Very High
Genetic Translocation 3 99.28 Very High Very High Very High
Glioma 253 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Male adult mice were treated with the antiherpes agent ganciclovir that selectively ablates cells expressing TK.
Gene_expression (expressing) of TK
1) Confidence 0.51 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11578531 Disease Relevance 0.33 Pain Relevance 0.23
High levels of tk expression by the Phsp60 could possibly be toxic to the mycobacteria, though this was not observed in this study.
Gene_expression (expression) of tk
2) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2706987 Disease Relevance 0.89 Pain Relevance 0.20
We were successful in engineering a strain of M. tuberculosis H37Rv expressing TK under the control of Phsp60 - a highly active constitutive mycobacterial promoter.
Gene_expression (expressing) of TK associated with mycobacterial infection and sprains and strains
3) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2706987 Disease Relevance 1.30 Pain Relevance 0.07
Use of more active mycobacterial promoters such as PA37 and PblaF* [7], [8] driving TK expression or TK substrates more specific for bacterial TK, may also increase sensitivity.
Gene_expression (expression) of TK
4) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2706987 Disease Relevance 1.22 Pain Relevance 0.10
Since mycobacteria lack TK, we engineered and characterized a M. tuberculosis strain expressing TK and used it to detect and localize M. tuberculosis in live animals in situ.


Gene_expression (expressing) of TK associated with mycobacterial infection and sprains and strains
5) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2706987 Disease Relevance 0.84 Pain Relevance 0.04
Use of more active mycobacterial promoters such as PA37 and PblaF* [7], [8] driving TK expression or TK substrates more specific for bacterial TK, may also increase sensitivity.
Gene_expression (expression) of TK
6) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2706987 Disease Relevance 1.22 Pain Relevance 0.11
Though other investigators have used viral tk expression systems for FIAU imaging, we utilized a bacterial tk gene to ensure the likelihood of efficient translation and activity in M. tuberculosis.
Gene_expression (expression) of tk associated with mycobacterial infection and imagery
7) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2706987 Disease Relevance 0.59 Pain Relevance 0.50
The researchers reveal that TLR2 was responding to high-mobility-group box 1 (HMGB1), a protein released by the dying tumor cells by showing that treatment of the tumor-bearing mice with the HMGB1 inhibitor glycyrrhizin blocked the therapeutic effect of Flt3L/TK expression.
Gene_expression (expression) of TK associated with cancer
8) Confidence 0.24 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.28 Pain Relevance 0
Expression of both Flt3L and TK (but not of either protein alone) plus gancyclovir treatment shrank the tumors and greatly improved the survival of the mice.
Gene_expression (Expression) of TK associated with cancer
9) Confidence 0.24 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.20 Pain Relevance 0
Finally, the researchers report that other tumor cell types release HMGB1 when they are killed and that the Flt3L/TK expression strategy can also kill other tumors growing in mouse brains.


Gene_expression (expression) of TK in brains associated with cancer
10) Confidence 0.24 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.23 Pain Relevance 0
Then, they injected harmless viruses carrying the genes for Fms-like tyrosine kinase 3 ligand (Ftl3L; a protein that attracts dendritic cells) and for thymidine kinase (TK; cells expressing TK are killed by a drug called gancyclovir) into the tumor.
Gene_expression (expressing) of TK in dendritic cells associated with cancer and fibromyalgia
11) Confidence 0.24 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.25 Pain Relevance 0
Using a combined immunotherapy/conditional cytotoxic approach that utilizes adenoviral vectors (Ad) expressing Fms-like tyrosine kinase 3 ligand (Flt3L) and thymidine kinase (TK) delivered into the tumor mass, we demonstrated that CD4+ and CD8+ T cells were required for tumor regression and immunological memory.
Gene_expression (expressing) of TK in T cells associated with cancer and fibromyalgia
12) Confidence 0.24 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.42 Pain Relevance 0.04
in the regulation of TK and TK receptor gene expression.
Gene_expression (expression) of TK
13) Confidence 0.22 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.09
in the regulation of TK and TK receptor gene expression.
Gene_expression (expression) of TK
14) Confidence 0.22 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.09
To uncover the role of TLR signaling in brain tumor regression and immunological memory, we developed a syngeneic, intracranial mouse glioma model; treatment consisted of intratumoral delivery of Ads expressing Flt3L and TK (Ad-TK + Ad-Flt3L), followed by systemic delivery of GCV.
Gene_expression (expressing) of TK in brain associated with glioma and brain tumor
15) Confidence 0.19 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.57 Pain Relevance 0
We administered glycyrrhizin 2, 5, and 10 d after injection of Ad-Flt3L and Ad-TK or saline.
Gene_expression (injection) of TK
16) Confidence 0.18 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.23 Pain Relevance 0
Briefly, the following changes were introduced into the wild-type Scn9a (Figure 2A): the p.N641Y mutation into exon 11, the ACN positive selection vector into intron 10, and the negative TK selection vector into intron 12 (Figure 2B).
Neg (negative) Gene_expression (introduced) of TK in ACN
17) Confidence 0.18 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2730533 Disease Relevance 0.67 Pain Relevance 0.03
To uncover the role of TLR signaling in brain tumor regression and immunological memory, we developed a syngeneic, intracranial mouse glioma model; treatment consisted of intratumoral delivery of Ads expressing Flt3L and TK (Ad-TK + Ad-Flt3L), followed by systemic delivery of GCV.
Gene_expression (expressing) of TK in brain associated with glioma and brain tumor
18) Confidence 0.16 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.57 Pain Relevance 0
We used first generation, recombinant Ads (serotype 5) expressing Herpes Simplex Virus Type I-TK (Ad-TK) [8,27], Flt3L (Ad-Flt3L) [7], and an Ad vector with no transgene (Ad0) in this study [8].
Gene_expression (expressing) of TK associated with herpes simplex virus
19) Confidence 0.16 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.79 Pain Relevance 0
We used first generation, recombinant Ads (serotype 5) expressing Herpes Simplex Virus Type I-TK (Ad-TK) [8,27], Flt3L (Ad-Flt3L) [7], and an Ad vector with no transgene (Ad0) in this study [8].
Gene_expression (expressing) of TK associated with herpes simplex virus
20) Confidence 0.16 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.79 Pain Relevance 0

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