INT98380

Context Info Confidence 0.02 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Title Documents 1 Total Number 1 Disease Relevance 0.35 Pain Relevance 0.23

cytoplasm (Pomc, Oprd1) signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc) extracellular region (Pomc) plasma membrane (Oprd1)

Anatomy Link Frequency midbrain 1 Pomc (Mus musculus) Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat mu opioid receptor 3 100.00 midbrain 1 100.00 Opioid 1 91.40 opioid receptor 1 84.56 Central grey 1 44.20 Raphe 1 43.36 Delta opioid receptors 1 36.24

Disease Link Frequency Relevance Heat Targeted Disruption 2 99.28 Stress 1 95.84 Herpes Simplex Virus 1 76.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Ablation of pituitary pro-opiomelanocortin (POMC) cells produces alterations in hypothalamic POMC mRNA levels and midbrain mu opioid receptor binding in a conditional transgenic mouse model.

POMC mRNA Binding (binding) of opioid receptor in midbrain associated with targeted disruption, mu opioid receptor and midbrain

1) Confidence 0.02 Published 2001 Journal J. Neuroendocrinol. Section Title Doc Link 11578531 Disease Relevance 0.35 Pain Relevance 0.23

General Comments

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