INT98392

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.35
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
Spt (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 98.60 Very High Very High Very High
agonist 1 98.12 Very High Very High Very High
Hsan 1 88.88 High High
Pain 15 81.04 Quite High
Neuropathic pain 1 73.60 Quite High
Paracetamol 1 67.20 Quite High
Oxycodone 4 50.00 Quite Low
Analgesic 1 50.00 Quite Low
Angina 1 50.00 Quite Low
colic 1 22.96 Low Low
Disease Link Frequency Relevance Heat
Shock 1 99.38 Very High Very High Very High
Eczema 15 99.14 Very High Very High Very High
Stress 4 98.38 Very High Very High Very High
Adverse Drug Reaction 30 96.04 Very High Very High Very High
Neuropathic Pain 19 96.04 Very High Very High Very High
Hypersensitivity 11 91.88 High High
Milk Hypersensitivity 9 89.32 High High
Hereditary Sensory And Autonomic Neuropathies 1 88.88 High High
Pain 15 81.04 Quite High
Death 2 71.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, they increased significantly after the SPT, thereby the magnitude of increases immediately after and 6 h after the SPT were significantly (P<0.001 and P<0.01, respectively) greater in the positive group than in the negative.
Positive_regulation (increased) of SPT
1) Confidence 0.39 Published 2001 Journal Int. J. Cardiol. Section Body Doc Link 11578721 Disease Relevance 0.13 Pain Relevance 0
Recent work has also revealed that diverse agonists and stresses (cytokines, UV light, glucocorticoids, heat shock and toxic compounds) modulate SPT activity by induction of SPTLC2 gene transcription and/or post-translational modification.
Positive_regulation (induction) of SPT associated with stress, shock, agonist and cytokine
2) Confidence 0.18 Published 2001 Journal Biochem. Soc. Trans. Section Abstract Doc Link 11709083 Disease Relevance 0.36 Pain Relevance 0.19
In order to test our hypothesis whether ceramide synthase inhibition by fumonisin B1 alters other sphingolipid-metabolizing enzymes, we investigated the changes in free sphingoid bases and sphingomyelin (SM) and activities of key enzymes for their metabolism, sphingomyelinase (SMase), serine palmitoyltransferase (SPT), and sphingosine kinase (SPHK) in mouse liver.
Positive_regulation (enzymes) of SPT in liver
3) Confidence 0.17 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16960033 Disease Relevance 0 Pain Relevance 0.07
The activity of SPT with alanine and glycine is greatly increased in the presence of several SPT missense mutations which are associated with the inherited sensory neuropathy HSAN1 (OMIM162400).
Positive_regulation (increased) of SPT associated with neuropathic pain
4) Confidence 0.15 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2931514 Disease Relevance 0.41 Pain Relevance 0.15
CYP3A4 blockade had a major effect on all pharmacodynamic assessments and SPT increased by 15%.
Positive_regulation (increased) of SPT
5) Confidence 0.01 Published 2010 Journal Br. J. Pharmacol. Section Body Doc Link 20590588 Disease Relevance 0 Pain Relevance 0
Just one child, the one with atopic dermatitis as the presenting symptom, had a positive SPT, as well as elevated IgE level to cow's milk proteins.
Positive_regulation (elevated) of SPT associated with eczema
6) Confidence 0.01 Published 2008 Journal Acta Paediatrica (Oslo, Norway : 1992) Section Body Doc Link PMC2253707 Disease Relevance 1.46 Pain Relevance 0.13

General Comments

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