INT984

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Context Info
Confidence 0.70
First Reported 1979
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 58
Total Number 61
Disease Relevance 12.66
Pain Relevance 16.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRH) extracellular region (GHRH) cell-cell signaling (GHRH)
Anatomy Link Frequency
hypothalamus 6
plasma 6
muscle 4
anterior pituitary 4
nerve 2
GHRH (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 11 100.00 Very High Very High Very High
Pain threshold 5 100.00 Very High Very High Very High
Neuropeptide 1 100.00 Very High Very High Very High
Clonidine 170 99.98 Very High Very High Very High
Opioid 9 99.98 Very High Very High Very High
Morphine 6 99.98 Very High Very High Very High
narcan 8 99.84 Very High Very High Very High
Somatostatin 37 99.82 Very High Very High Very High
agonist 20 99.78 Very High Very High Very High
opiate 4 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 10 100.00 Very High Very High Very High
Obesity 33 99.84 Very High Very High Very High
Diabetes Mellitus 23 99.84 Very High Very High Very High
Uremia 4 99.84 Very High Very High Very High
Hypercalcemia 4 99.74 Very High Very High Very High
Aging 6 99.68 Very High Very High Very High
Cluster Headache 1 99.64 Very High Very High Very High
Stress 14 99.60 Very High Very High Very High
Endocrine Disease 1 99.40 Very High Very High Very High
Anaemia 3 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, alpha 2-adrenergic agonism appears to act primarily in GH control by inhibiting the hypothalamic release of somatostatin, rather than by stimulating GHRH secretion.
Positive_regulation (stimulating) of Localization (secretion) of GHRH associated with somatostatin
1) Confidence 0.70 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1977761 Disease Relevance 0 Pain Relevance 0.40
The interaction between clonidine and growth hormone releasing hormone in the stimulation of growth hormone secretion in man.
Positive_regulation (stimulation) of Localization (secretion) of growth hormone associated with clonidine
2) Confidence 0.70 Published 1990 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 2147600 Disease Relevance 0 Pain Relevance 0.60
The stimulatory effect of clonidine on GH secretion has been suggested to depend on an enhancement of hypothalamic GH-releasing hormone (GHRH) release.
Positive_regulation (enhancement) of Localization (release) of GHRH associated with clonidine
3) Confidence 0.69 Published 1991 Journal Horm. Res. Section Abstract Doc Link 1823078 Disease Relevance 0.59 Pain Relevance 0.33
This action is probably mediated at the level of the hypothalamus, where the drug may act through inhibition of somatostatin (SRIH) and/or stimulation of GH-releasing hormone (GHRH) release.
Positive_regulation (stimulation) of Localization (release) of GHRH in hypothalamus associated with somatostatin
4) Confidence 0.69 Published 1994 Journal Endocrinology Section Abstract Doc Link 7905408 Disease Relevance 0 Pain Relevance 0.65
Opioids stimulate growth hormone (GH) release in man independently of GH-releasing hormone.
Positive_regulation (stimulate) of Localization (release) of growth hormone associated with opioid
5) Confidence 0.69 Published 1989 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 2546963 Disease Relevance 0 Pain Relevance 0.33
This effect is most likely due to stimulation of hypothalamic growth hormone releasing hormone (GHRH) release.
Positive_regulation (stimulation) of Localization (release) of GHRH
6) Confidence 0.68 Published 1995 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 7584524 Disease Relevance 0 Pain Relevance 0.47
It is well established that the central alpha 2-adrenergic agonist clonidine can enhance growth hormone (GH) secretion in humans.
Positive_regulation (enhance) of Localization (secretion) of growth hormone associated with agonist and clonidine
7) Confidence 0.68 Published 1995 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 7584524 Disease Relevance 0 Pain Relevance 0.44
Clonidine-induced growth hormone release may be a potentially useful neuroendocrine marker indicating derangement of certain components of the central alpha-adrenergic system in man.
Positive_regulation (induced) of Localization (release) of growth hormone associated with clonidine
8) Confidence 0.66 Published 1984 Journal Clin Exp Hypertens A Section Abstract Doc Link 6398141 Disease Relevance 0.09 Pain Relevance 0.30
The effect of acute hypercalcaemia on arginine induced growth hormone release in diabetic man.
Positive_regulation (induced) of Localization (release) of growth hormone associated with diabetes mellitus and hypercalcemia
9) Confidence 0.55 Published 1984 Journal Horm. Metab. Res. Section Title Doc Link 6532933 Disease Relevance 1.05 Pain Relevance 0.09
It is well documented that the infusion of arginine stimulated growth hormone secretion from the anterior pituitary [5,7].
Positive_regulation (stimulated) of Localization (secretion) of growth hormone in anterior pituitary
10) Confidence 0.55 Published 2004 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129157 Disease Relevance 0 Pain Relevance 0.08
This increase in growth hormone secretion from arginine infusion has been attributed to the suppression of endogenous somatostatin secretion [8].
Positive_regulation (increase) of Localization (secretion) of growth hormone associated with somatostatin
11) Confidence 0.55 Published 2004 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129157 Disease Relevance 0 Pain Relevance 0.08
This action is probably mediated at the level of the hypothalamus, where the drug may act through inhibition of somatostatin (SRIH) and/or stimulation of GH-releasing hormone (GHRH) release.
Positive_regulation (stimulation) of Localization (release) of GH-releasing hormone in hypothalamus associated with somatostatin
12) Confidence 0.50 Published 1994 Journal Endocrinology Section Abstract Doc Link 7905408 Disease Relevance 0 Pain Relevance 0.65
The acute administration of glucocorticoids is a new stimulus of growth hormone (GH) secretion in man.
Positive_regulation (stimulus) of Localization (secretion) of growth hormone
13) Confidence 0.50 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8284031 Disease Relevance 0.16 Pain Relevance 0.13
Corticoid-induced growth hormone (GH) secretion in GH-deficient and normal children.
Positive_regulation (Corticoid-induced) of Localization (secretion) of growth hormone
14) Confidence 0.50 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 1639956 Disease Relevance 0.08 Pain Relevance 0.11
Short-term studies have proved that correction of anemia with rhEPO therapy is accompanied by several changes in growth hormone (GH) secretion in uremic patients.
Positive_regulation (changes) of Localization (secretion) of growth hormone associated with anaemia and uremia
15) Confidence 0.49 Published 1999 Journal Metab. Clin. Exp. Section Abstract Doc Link 10024084 Disease Relevance 0.99 Pain Relevance 0.05
In contrast, pretreatment with yohimbine significantly (P less than 0.05) blunted the pyridostigmine-induced enhancement of GHRH-elicited GH release.
Positive_regulation (enhancement) of Localization (release) of GHRH
16) Confidence 0.49 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1677361 Disease Relevance 0 Pain Relevance 0.50
The effect of cyproheptadine on growth hormone (GH) secretion and dental pain threshold elevation during physical exercise was studied in healthy human subjects.
Positive_regulation (elevation) of Localization (secretion) of growth hormone associated with pain threshold
17) Confidence 0.49 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 3774237 Disease Relevance 0.41 Pain Relevance 0.47
CONCLUSIONS: These results indicate that clonidine and l-dopa stimulate GH secretion mainly through the release of hypothalamic GHRH, and that arginine- and insulin-induced hypoglycaemia stimulate GH secretion mainly through the inhibition of hypothalamic somatostatin release.
Positive_regulation (stimulate) of Localization (release) of GHRH
18) Confidence 0.48 Published 2002 Journal Eur. J. Endocrinol. Section Body Doc Link 11834428 Disease Relevance 0 Pain Relevance 0
It is well known that the acute administration of clonidine, an alpha 2-adrenergic agonist commonly used as an antihypertensive drug, stimulates GH secretion, likely via hypothalamic growth hormone releasing hormone (GHRH) release.
Spec (likely) Positive_regulation (stimulates) of Localization (release) of GHRH associated with agonist and clonidine
19) Confidence 0.48 Published 1991 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 1907565 Disease Relevance 0.18 Pain Relevance 0.45
It is suggested that clonidine stimulates hGH secretion mainly through an enhancement of GHRH release, whereas stress stimuli such as hypoglycemia and exercise achieve hGH release by a different mechanism, possibly inhibition of somatostatin.
Positive_regulation (enhancement) of Localization (release) of GHRH associated with hypoglycemia, stress, somatostatin and clonidine
20) Confidence 0.48 Published 1990 Journal Acta Endocrinol. Section Abstract Doc Link 2106191 Disease Relevance 0.41 Pain Relevance 0.68

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