INT9840

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Context Info
Confidence 0.57
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 17.83
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F7) extracellular space (F7) extracellular region (F7)
plasma membrane (F7)
Anatomy Link Frequency
blood 3
plasma 2
pericardium 1
F7 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 22 99.98 Very High Very High Very High
cva 84 97.32 Very High Very High Very High
aspirin 10 96.96 Very High Very High Very High
abdominal pain 2 88.16 High High
anesthesia 7 79.12 Quite High
Paracetamol 3 75.00 Quite High
Spinal cord 2 71.20 Quite High
Inflammation 8 70.52 Quite High
ischemia 3 70.24 Quite High
Cauda equina syndrome 6 67.00 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 10 99.36 Very High Very High Very High
Coagulation Disorder 317 99.22 Very High Very High Very High
Hemorrhage 288 98.68 Very High Very High Very High
Thrombophilia 2 98.20 Very High Very High Very High
Injury 229 97.96 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 9 97.40 Very High Very High Very High
Obesity 2 96.86 Very High Very High Very High
Myocardial Infarction 24 96.44 Very High Very High Very High
Renal Failure 4 94.56 High High
Aging 5 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The prothrombin time ratio decreased along with an increase in the factor VII level.
Positive_regulation (increase) of factor VII
1) Confidence 0.57 Published 1992 Journal Thromb. Res. Section Abstract Doc Link 1440517 Disease Relevance 0.82 Pain Relevance 0.06
Moreover, obese people, like our patient, have higher plasminogen activator inhibitor type 1 plasma levels than normal controls, resulting in a hypofibrinolytic state, and elevated plasma levels of coagulation factor VII, fibrinogen and tissue factor, leading to a hypercoagulability state [7–9].
Positive_regulation (elevated) of coagulation factor VII in plasma associated with thrombophilia and obesity
2) Confidence 0.45 Published 2007 Journal J Neurol Section Body Doc Link PMC2780628 Disease Relevance 1.55 Pain Relevance 0.20
These findings indicated that the procoagulant activity of factor VII was enhanced by low protein C levels, suggesting that concomitant factor VII hyperactivity may cause acute myocardial infarction in patients with protein C deficiency.
Positive_regulation (enhanced) of factor VII associated with attention deficit hyperactivity disorder and myocardial infarction
3) Confidence 0.41 Published 1992 Journal Thromb. Res. Section Abstract Doc Link 1440517 Disease Relevance 0.96 Pain Relevance 0.06
To study the effects of protein C and factor VII on procoagulant activity, prothrombin time was measured after the addition of activated protein C and factor VII to protein C-deficient plasma.
Positive_regulation (activated) of factor VII in plasma
4) Confidence 0.38 Published 1992 Journal Thromb. Res. Section Abstract Doc Link 1440517 Disease Relevance 0.86 Pain Relevance 0.07
We experienced the perioperative management of a patient with hemophilia A having inhibitors using recombinant activated factor VII (rF VIIa).
Positive_regulation (activated) of factor VII associated with coagulation disorder
5) Confidence 0.22 Published 2005 Journal Masui Section Abstract Doc Link 16104555 Disease Relevance 0.23 Pain Relevance 0.07
[Perioperative use of recombinant activated factor VII (rF VIIa) in a patient with hemophilia A having inhibitors].
Positive_regulation (activated) of factor VII associated with coagulation disorder
6) Confidence 0.20 Published 2005 Journal Masui Section Title Doc Link 16104555 Disease Relevance 0.33 Pain Relevance 0.08
Progressive coagulopathy and hemodynamic compromise necessitated continued transfusion of blood and blood products and the intravenous administration of activated Factor VII (VIIa).
Positive_regulation (activated) of Factor VII in blood associated with coagulation disorder
7) Confidence 0.18 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2827427 Disease Relevance 1.27 Pain Relevance 0.10
In addition, activated prothrombin complex concentrates and recombinant activated factor VII were intravenously administered which successfully controlled his hemorrhage.
Positive_regulation (activated) of factor VII associated with cva
8) Confidence 0.17 Published 2006 Journal Rinsho Ketsueki Section Abstract Doc Link 16715966 Disease Relevance 1.29 Pain Relevance 0.17
In addition, activated prothrombin complex concentrates and recombinant activated factor VII were intravenously administered which successfully controlled his hemorrhage.
Positive_regulation (activated) of factor VII associated with cva
9) Confidence 0.17 Published 2006 Journal Rinsho Ketsueki Section Abstract Doc Link 16715966 Disease Relevance 1.27 Pain Relevance 0.17
We suggest that the use of recombinant activated coagulation factor VII (rFVIIa) be considered if major bleeding in blunt trauma persists despite standard attempts to control bleeding and best-practice use of blood components (Grade 2C).


Positive_regulation (activated) of coagulation factor VII in blood associated with injury and hemorrhage
10) Confidence 0.16 Published 2010 Journal Crit Care Section Body Doc Link PMC2887168 Disease Relevance 1.18 Pain Relevance 0.03
TF forms a highly procoagulant complex with activated coagulation factor VII (FVIIa).
Positive_regulation (activated) of factor VII
11) Confidence 0.13 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10521382 Disease Relevance 0.09 Pain Relevance 0.37
Humate-P was chosen based on the lack of an alternative bypass agent such as recombinant activated FVII (rFVIIa) in the setting of acute severe bleeding.
Positive_regulation (activated) of FVII associated with hemorrhage
12) Confidence 0.10 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918632 Disease Relevance 0.24 Pain Relevance 0
In patients with higher titers of inhibitor, activated factor VII can be used [2].
Positive_regulation (activated) of factor VII
13) Confidence 0.10 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918632 Disease Relevance 1.12 Pain Relevance 0.06
Recombinant activated coagulation FVII (rFVIIa) has recently been licensed for use in acquired hemophilia in the US [2].
Positive_regulation (activated) of FVII associated with coagulation disorder
14) Confidence 0.09 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2918632 Disease Relevance 1.11 Pain Relevance 0.06
Progressive coagulopathy and hemodynamic compromise necessitated continued transfusion of blood and blood products and the intravenous administration of activated Factor VII (VIIa).
Positive_regulation (activated) of Factor VII in blood associated with coagulation disorder
15) Confidence 0.06 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2827427 Disease Relevance 1.27 Pain Relevance 0.10
Concomitant replacement therapy, especially with bypassing agents (ie, activated or non-activated prothrombin complex concentrates and recombinant activated factor VII), was identified as having a predominant role in thrombotic manifestations in the majority of the cases (Aledort 2004).
Positive_regulation (activated) of factor VII
16) Confidence 0.02 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2685275 Disease Relevance 1.61 Pain Relevance 0
However, Leebek et al (2006) have recently reported the safe and effective use of recombinant activated factor VII in three elderly patients with mild hemophilia A and high-titer inhibitors.


Positive_regulation (activated) of factor VII associated with coagulation disorder
17) Confidence 0.02 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2685275 Disease Relevance 1.80 Pain Relevance 0.04
No significant differences were observed in Ch, TG and HDL-C when the period of addiction increased iii) Lpa, apo B, HbA1C, CRP, SGOT, SGPT, Fibrinogen, Factor VII and LDL augmented significantly when the period of addiction increased more than 2 years but apoA decreased significantly.


Positive_regulation (increased) of Factor VII associated with addiction and disorder of lipid metabolism
18) Confidence 0.01 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2588593 Disease Relevance 0.75 Pain Relevance 0.43
More recently, Philippou et al. [23] demonstrated that pericardium-induced activation of factor VII, due to ineffective local heparinization, resulted in an increased thrombin generation.
Positive_regulation (activation) of factor VII in pericardium
19) Confidence 0.01 Published 2003 Journal Thromb J Section Body Doc Link PMC179879 Disease Relevance 0.08 Pain Relevance 0

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