INT98445

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Context Info
Confidence 0.32
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 7.24
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BPHL) cellular amino acid metabolic process (BPHL)
BPHL (Homo sapiens)
Pain Link Frequency Relevance Heat
Onset of action 6 97.56 Very High Very High Very High
antagonist 48 94.40 High High
cINOD 14 91.60 High High
Botox 56 89.76 High High
noradrenaline 1 84.04 Quite High
Peripheral sensitization 1 75.84 Quite High
headache 3 69.12 Quite High
Neurotransmitter 5 58.80 Quite High
Inflammation 27 47.28 Quite Low
agonist 5 41.52 Quite Low
Disease Link Frequency Relevance Heat
Benign Prostatic Hypertrophy 482 100.00 Very High Very High Very High
Overactive Bladder 379 100.00 Very High Very High Very High
Lower Urinary Tract Symptoms 157 98.32 Very High Very High Very High
Diuresis 38 94.40 High High
Reprotox - General 1 33 88.08 High High
Hypoactive Sexual Desire Disorder 1 87.12 High High
Gynecomastia 4 85.76 High High
Reprotox - General 2 30 85.20 High High
Hyperplasia 8 76.36 Quite High
Frailty 5 75.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Risk reduction of acute urinary retention was 57% and the risk reduction of BPH-related surgery was 48% compared with placebo.
Negative_regulation (reduction) of BPH-related associated with benign prostatic hypertrophy and overactive bladder
1) Confidence 0.32 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778433 Disease Relevance 0.98 Pain Relevance 0.03
In appropriate BPH patients, 5ARI therapy can reduce the risk of AUR and the need for BPH-related surgery (McConnell et al 2003).
Negative_regulation (reduce) of BPH associated with benign prostatic hypertrophy
2) Confidence 0.16 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682383 Disease Relevance 1.22 Pain Relevance 0.05
The factors which are considered as predictors of AUR in BPH can be divided into baseline and dynamic variables.
Negative_regulation (predictors) of BPH associated with benign prostatic hypertrophy and overactive bladder
3) Confidence 0.15 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 1.81 Pain Relevance 0.57
Alpha blockers can prevent AUR in symptomatic BPH patients and also facilitate catheter removal following episodes of spontaneous AUR.
Negative_regulation (prevent) of BPH associated with benign prostatic hypertrophy and overactive bladder
4) Confidence 0.15 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Abstract Doc Link PMC2721562 Disease Relevance 1.63 Pain Relevance 0
Alpha 1-blockers should be used in first-line medical therapy for BPH and 5-alpha-reductase inhibitors reserved for those patients in whom alpha-blocker therapy fails.
Negative_regulation (inhibitors) of BPH associated with benign prostatic hypertrophy
5) Confidence 0.11 Published 2001 Journal Int Urol Nephrol Section Abstract Doc Link 11583366 Disease Relevance 0.68 Pain Relevance 0.16
Analysis of gene expression differences in RNA samples extracted from intact tissues does not specifically allow for localization of the increased or decreased altered genes to the glandular and/or stromal compartments in TZ tissues, both of which likely contribute fundamentally to evolution of BPH, nor does it necessarily translate to altered levels of more biologically relevant proteins.
Negative_regulation (evolution) of BPH associated with benign prostatic hypertrophy
6) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 0.54 Pain Relevance 0
The cholinergic and nitrinergic innervation are reduced in BPH as compared to that in normal prostate tissue.
Negative_regulation (reduced) of BPH associated with benign prostatic hypertrophy
7) Confidence 0.04 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687757 Disease Relevance 0.39 Pain Relevance 0.27

General Comments

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