INT98449

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.96
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Anatomy Link Frequency
paw 2
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Restless leg syndrome 5 96.96 Very High Very High Very High
cytokine 10 96.64 Very High Very High Very High
Inflammation 12 91.56 High High
Pain 1 86.04 High High
tolerance 2 75.60 Quite High
Arthritis 1 75.48 Quite High
Paracetamol 2 61.00 Quite High
cINOD 1 60.96 Quite High
Analgesic 3 25.00 Low Low
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 5 96.96 Very High Very High Very High
Injury 12 92.00 High High
INFLAMMATION 15 91.56 High High
Disorder Of Lipid Metabolism 4 91.12 High High
Nociception 4 90.68 High High
Toxicity 28 87.52 High High
Pain 1 86.04 High High
Dyslipidemia /

Combined Dyslipidemia

1 82.04 Quite High
Necrosis 8 76.92 Quite High
Cancer 6 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether a reduction of IL-6 contributes to the improvement of lipid profiles, we prospectively investigated the effect of cilostazol (n=16, 100 mg, twice daily) on the changes of lipid profiles and on the association with the changes of IL-6 compared with those of pentoxifylline (n=16, 400 mg, bid) in patients with IC.
Positive_regulation (changes) of IL-6 Binding (association) of associated with restless leg syndrome
1) Confidence 0.44 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11583728 Disease Relevance 0.67 Pain Relevance 0.45
and its receptor, along with interleukin-6 (IL-6) and its receptor, were both upregulated in the present study, but neither was correlated with a tissue metric below the 0.01 p-value threshold.
Positive_regulation (upregulated) of interleukin-6 Binding (receptor) of
2) Confidence 0.17 Published 2003 Journal Genome Biol Section Body Doc Link PMC156588 Disease Relevance 0.64 Pain Relevance 0.28
and its receptor, along with interleukin-6 (IL-6) and its receptor, were both upregulated in the present study, but neither was correlated with a tissue metric below the 0.01 p-value threshold.
Positive_regulation (upregulated) of IL-6 Binding (receptor) of
3) Confidence 0.17 Published 2003 Journal Genome Biol Section Body Doc Link PMC156588 Disease Relevance 0.63 Pain Relevance 0.28
The administration of alphaLA 1 h before carrageenan injection inhibited the increased formation of IL-6 and PGE(2) in paw exudates.
Positive_regulation (increased) of IL-6 Binding (formation) of in paw
4) Confidence 0.13 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19252279 Disease Relevance 0.94 Pain Relevance 0.42

General Comments

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