INT98453

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 7.84
Pain Relevance 4.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Src) enzyme binding (Src) cytoplasm (Src)
cell proliferation (Src) cell adhesion (Src) nucleus (Src)
Anatomy Link Frequency
forebrain 2
neurons 1
chromaffin cells 1
extracellular matrix 1
smooth muscle cells 1
Src (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 84 99.90 Very High Very High Very High
nMDA receptor 6 99.66 Very High Very High Very High
opioid receptor 169 99.06 Very High Very High Very High
Morphine 168 97.92 Very High Very High Very High
Nucleus accumbens 2 95.44 Very High Very High Very High
agonist 18 94.16 High High
fibrosis 6 93.52 High High
Glutamate 20 90.80 High High
interneuron 1 88.16 High High
nMDA receptor antagonist 2 87.52 High High
Disease Link Frequency Relevance Heat
Erythrocytosis 70 99.92 Very High Very High Very High
Cancer 440 99.46 Very High Very High Very High
Breast Cancer 28 99.46 Very High Very High Very High
Disorder Of Lipid Metabolism 1 99.42 Very High Very High Very High
Adhesions 25 98.08 Very High Very High Very High
Reticulocytosis 10 97.84 Very High Very High Very High
Malignant Neoplastic Disease 8 97.48 Very High Very High Very High
Stomach Cancer 11 96.08 Very High Very High Very High
Fibrosis 6 93.52 High High
Bordatella Infection 6 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that Tyr-1472 phosphorylation of NR2B subunit-containing NMDA receptor associated with activation of Src family kinase in the limbic forebrain may be involved in the morphine-induced rewarding effect.
Positive_regulation (activation) of Src in forebrain associated with nmda receptor and morphine
1) Confidence 0.47 Published 2006 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 16866212 Disease Relevance 0 Pain Relevance 0.67
In addition, the level of phospho-Tyr-416 Src family kinase was also increased in the limbic forebrain of mice that had shown the morphine-induced rewarding effect.
Positive_regulation (increased) of Src in forebrain associated with morphine
2) Confidence 0.41 Published 2006 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 16866212 Disease Relevance 0 Pain Relevance 0.68
The localization of the nonreceptor tyrosine kinase c-Src appeared disrupted in beta arr2-/- neurons, and there was reduced activation of c-Src by DAMGO.
Positive_regulation (activation) of Src in neurons
3) Confidence 0.32 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17494695 Disease Relevance 0.14 Pain Relevance 0.56
The reeler gene encodes Reelin, a secreted glycoprotein that binds to the very-low-density lipoprotein receptor (Vldlr) and apolipoprotein E receptor 2 (Apoer 2), and induces Src- and Fyn-mediated tyrosine phosphorylation of the intracellular adaptor protein Disabled-1 (Dab1).
Positive_regulation (induces) of Src associated with disorder of lipid metabolism
4) Confidence 0.31 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279306 Disease Relevance 0.17 Pain Relevance 0.04
During catalytic deamination, LOX generates hydrogen peroxide, a species that can act as a chemoattractant for vascular smooth muscle cells [18] and breast cancer cells [20], and that also activates FAK and Src [20]; in this way, LOX may be able to indirectly modulate cell adhesion and motility [17], [48].
Positive_regulation (activates) of Src in smooth muscle cells associated with breast cancer and adhesions
5) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2680032 Disease Relevance 0.69 Pain Relevance 0
Using donor mice with mutations in Lyn, Hck, and Fgr, we demonstrated that the polycythemia was independent of Src kinases.
Neg (independent) Positive_regulation (independent) of Src associated with erythrocytosis
6) Confidence 0.28 Published 2006 Journal PLoS ONE Section Abstract Doc Link PMC1762384 Disease Relevance 1.83 Pain Relevance 0.05
JAK2 V617F-induced polycythemia is independent of Src kinases
Neg (independent) Positive_regulation (independent) of Src associated with erythrocytosis
7) Confidence 0.28 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 1.47 Pain Relevance 0.03
There is a possibility, however, that MOR may regulate other events upstream of PKC and Src activation as well.
Positive_regulation (activation) of Src associated with kinase c and opioid receptor
8) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.34 Pain Relevance 0.78
A novel variation of this signaling pathway has been described in which the C-type lectin family receptors, CLEC-2, Dectin-1, and CLEC-9A, signal through sequential activation of Src and Syk family tyrosine kinases downstream of a single YxxL sequence [1–3].
Positive_regulation (activation) of Src
9) Confidence 0.20 Published 2008 Journal Journal of Thrombosis and Haemostasis Section Body Doc Link PMC2710801 Disease Relevance 0 Pain Relevance 0
A cell-adhesion molecule, integrin, a receptor for extracellular matrix proteins, also negatively regulates RP induction through the Src-family of protein tyrosine kinases (Kawaguchi and Hirano, 2006).
Positive_regulation (induction) of Src in extracellular matrix associated with adhesions
10) Confidence 0.19 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.18 Pain Relevance 0.10
Network 9 (Figure 6) has IL-6, STAT5, and SRC in a central position.
Positive_regulation (has) of SRC
11) Confidence 0.15 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2262873 Disease Relevance 0.26 Pain Relevance 0.11
Since Stat3 inhibition also blocks VEGF expression in tumours characterized by aberrant activation of Src [77], therapeutic targeting of Stat3 may inhibit neovascularisation in tumours associated with excessive signaling through epidermal growth factor receptor.
Positive_regulation (activation) of Src associated with cancer
12) Confidence 0.14 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.88 Pain Relevance 0
calcium influx, and activation of protein tyrosine kinases (Pyk2, Src).
Positive_regulation (activation) of Src
13) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2440494 Disease Relevance 0.30 Pain Relevance 0.03
However, recent work has shown that LOX regulates a number of cellular functions including cell migration via the activation of FAK/Src pathway [41,24].
Positive_regulation (activation) of Src
14) Confidence 0.14 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.07 Pain Relevance 0.04
A number of GPCRs regulate NMDAR activity through the action of kinases such as Src and PKC [3], [37].
Positive_regulation (action) of Src associated with kinase c
15) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.15 Pain Relevance 1.08
These data demonstrate a voltage-independent mechanism for autocrine inhibition of P/Q-type Ca(2+) channel currents in chromaffin cells that requires Src family kinase activity and suggests that this may be a widely distributed pathway for Ca(2+) channel regulation.
Positive_regulation (requires) of Src in chromaffin cells
16) Confidence 0.10 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11583988 Disease Relevance 0 Pain Relevance 0.03
Characterization of the voltage-independent inhibition of Ca(2+) currents revealed that it did not involve protein kinase C-dependent signaling pathways but did require the activity of a Src family tyrosine kinase.
Positive_regulation (activity) of Src associated with kinase c
17) Confidence 0.06 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11583988 Disease Relevance 0.18 Pain Relevance 0.21
Characterization of the voltage-independent inhibition of Ca(2+) currents revealed that it did not involve protein kinase C-dependent signaling pathways but did require the activity of a Src family tyrosine kinase.
Neg (not) Positive_regulation (require) of Src associated with kinase c
18) Confidence 0.06 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11583988 Disease Relevance 0.18 Pain Relevance 0.21
CSK then works as a negative regulator of CagA-Shp2 signalling, because the inactivated Src family kinases lead to a down-regulation of the levels of CagA phophorylation and subsequent diminished CagA-Shp2 complex formation.
Positive_regulation (inactivated) of Src
19) Confidence 0.03 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2254585 Disease Relevance 0 Pain Relevance 0

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