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Context Info
Confidence 0.80
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.80
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Pain Term Frequency Confidence Heat
agonist 119 99.04 Very High Very High Very High
Kappa opioid receptor 24 93.28 High High
tolerance 6 86.32 High High
addiction 6 84.56 Quite High
Morphine 2 83.36 Quite High
adenocard 11 74.12 Quite High
Arthritis 1 60.16 Quite High
opiate 2 55.68 Quite High
mu opioid receptor 17 54.40 Quite High
fibrosis 2 51.20 Quite High
Disease Term Frequency Confidence Heat
Disease 24 98.76 Very High Very High Very High
Myocardial Infarction 4 63.44 Quite High
Pulmonary Disease 31 63.20 Quite High
Hypertension 6 62.24 Quite High
Arthritis 1 60.16 Quite High
Opiate Addiction 1 55.68 Quite High
Cancer 4 54.24 Quite High
Cystic Fibrosis 1 51.76 Quite High
Heart Disease 2 50.16 Quite High
Targeted Disruption 5 47.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After receptor activation, arrestins desensitize phosphorylated GPCRs, blocking further activation and initiating receptor internalization.
Phosphorylation (phosphorylated) of GPCRs
1) Confidence 0.80 Published 2001 Journal Nat. Rev. Neurosci. Section Abstract Doc Link 11584310 Disease Relevance 0 Pain Relevance 0.17
The cytosolic proteins, arrestins then bind the phosphorylated GPCRs and prevent further coupling of that GPCR with G proteins and so reduce second messenger synthesis.
Phosphorylation (phosphorylated) of GPCRs
2) Confidence 0.80 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644495 Disease Relevance 0 Pain Relevance 0.05
Arrestins bind specifically to active (phosphorylated) G-protein coupled receptors (GPCRs), and arrest or reduce signaling by these receptors. ?
Phosphorylation (phosphorylated) of GPCRs
3) Confidence 0.79 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0.12 Pain Relevance 0
G-protein-coupled receptor kinases (GRKs) interact with the agonist-activated form of G-protein-coupled receptors (GPCRs) to effect receptor phosphorylation and to initiate profound impairment of receptor signalling, or desensitization.
Phosphorylation (phosphorylation) of GPCRs associated with agonist
4) Confidence 0.61 Published 2005 Journal Cell. Signal. Section Abstract Doc Link 15894165 Disease Relevance 0.58 Pain Relevance 0.19
GRK phosphorylation of GPCRs partially uncouples the receptor from G?
Phosphorylation (phosphorylation) of GPCRs
5) Confidence 0.61 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.10 Pain Relevance 0.26
While these studies highlight the importance of GRK phosphorylation of GPCRs in mediating receptor internalization and desensitization, it is notable that partial internalization of Rog-A was still detected in response to higher doses of spiradoline, indicating that the receptor can be internalized through different mechanisms.
Phosphorylation (phosphorylation) of GPCRs
6) Confidence 0.61 Published 2005 Journal BMC Biol Section Body Doc Link PMC551613 Disease Relevance 0 Pain Relevance 0.21

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