INT98464

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.71
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SRC) cytoplasm (SRC) cytosol (SRC)
signal transduction (SRC) cell adhesion (SRC) nucleus (SRC)
Anatomy Link Frequency
myocardium 2
capillary 2
band 2
SRC (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 7 99.32 Very High Very High Very High
addiction 3 98.80 Very High Very High Very High
Opioid 6 98.44 Very High Very High Very High
tolerance 5 97.88 Very High Very High Very High
cytokine 16 91.92 High High
opiate 2 75.00 Quite High
agonist 2 74.48 Quite High
antagonist 2 74.00 Quite High
mu opioid receptor 2 73.56 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 276 99.68 Very High Very High Very High
Lung Cancer 8 98.80 Very High Very High Very High
Ovarian Cancer 8 98.28 Very High Very High Very High
Melanoma 4 97.64 Very High Very High Very High
Breast Cancer 9 97.20 Very High Very High Very High
Cancer 152 95.72 Very High Very High Very High
Malignant Neoplastic Disease 5 90.44 High High
Adhesions 24 73.92 Quite High
Apoptosis 25 71.52 Quite High
Retina Disease 1 68.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The middle arrow indicates a phosphorylated protein band that exhibited enhanced phosphorylation during RGD-stimulation and seems to be dependent on c-Src activation as it is greatly diminished upon inclusion of DNSrc.
Positive_regulation (dependent) of Positive_regulation (activation) of c-Src in band
1) Confidence 0.67 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.05
Arrestins also link GPCRs to several signalling pathways, including activation of the non-receptor tyrosine kinase SRC and mitogen-activated protein kinase.
Positive_regulation (link) of Positive_regulation (activation) of SRC
2) Confidence 0.49 Published 2001 Journal Nat. Rev. Neurosci. Section Abstract Doc Link 11584310 Disease Relevance 0.14 Pain Relevance 0.20
We have shown previously in vivo4, 5 that PO can cause integrin activation, resulting in cytoskeletal assembly and activation of c-Src and FAK, and tyrosine phosphorylation of several cytoskeleton-bound proteins in 24-48 h PO myocardium.
Positive_regulation (resulting) of Positive_regulation (activation) of c-Src in myocardium
3) Confidence 0.45 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2443357 Disease Relevance 0 Pain Relevance 0.08
MS and DAMGO induced Src activation which was required for VEGF receptor transactivation and opioid-induced EC proliferation and migration.
Positive_regulation (required) of Positive_regulation (activation) of Src associated with opioid
4) Confidence 0.44 Published 2006 Journal Microvasc. Res. Section Abstract Doc Link 16820176 Disease Relevance 0.07 Pain Relevance 0.69
MS and DAMGO induced Src activation which was required for VEGF receptor transactivation and opioid-induced EC proliferation and migration.
Positive_regulation (induced) of Positive_regulation (activation) of Src associated with opioid
5) Confidence 0.44 Published 2006 Journal Microvasc. Res. Section Abstract Doc Link 16820176 Disease Relevance 0.07 Pain Relevance 0.69
C-Src over-expression and elevated c-Src kinase activity was observed in pancreatic carcinoma cell lines.
Positive_regulation (expression) of Positive_regulation (over) of c-Src associated with pancreatic cancer
6) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.34 Pain Relevance 0.04
C-Src over-expression and elevated c-Src kinase activity was observed in pancreatic carcinoma cell lines.
Positive_regulation (expression) of Positive_regulation (-) of c-Src associated with pancreatic cancer
7) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.34 Pain Relevance 0.04
C-Src over-expression and elevated c-Src kinase activity was observed in pancreatic carcinoma cell lines.
Positive_regulation (-) of Positive_regulation (over) of c-Src associated with pancreatic cancer
8) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.34 Pain Relevance 0.04
C-Src over-expression and elevated c-Src kinase activity was observed in pancreatic carcinoma cell lines.
Positive_regulation (over) of Positive_regulation (-) of c-Src associated with pancreatic cancer
9) Confidence 0.24 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.34 Pain Relevance 0.04
Shp2 has also been coupled to VEGFR2 signaling pathways through Gab1 leading to Src activation resulting in increased migration and capillary formation (28).
Positive_regulation (leading) of Positive_regulation (activation) of Src in capillary
10) Confidence 0.08 Published 2010 Journal Apmis Section Body Doc Link PMC2806050 Disease Relevance 0.09 Pain Relevance 0

General Comments

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