INT98469

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.20
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Timp1) extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Timp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 47 100.00 Very High Very High Very High
agonist 10 98.08 Very High Very High Very High
dexamethasone 10 90.52 High High
Bile 2 81.44 Quite High
fibrosis 36 81.32 Quite High
Inflammation 38 76.60 Quite High
cINOD 3 67.64 Quite High
cytokine 28 64.88 Quite High
Inflammatory response 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 38 99.36 Very High Very High Very High
Fibrosis 33 97.64 Very High Very High Very High
Necrosis 3 95.44 Very High Very High Very High
Cancer 3 95.08 Very High Very High Very High
Injury 23 86.96 High High
INFLAMMATION 43 76.60 Quite High
Wound Healing 11 76.48 Quite High
Cirrhosis 30 75.96 Quite High
Liver Disease 3 65.84 Quite High
Anastomotic Leak 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TAA treatment increased transcription of both MMPs and TIMPs, but only TIMPs showed increased translation.
Positive_regulation (increased) of Transcription (transcription) of TIMP associated with metalloproteinase
1) Confidence 0.45 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2844613 Disease Relevance 0.68 Pain Relevance 0.38
There were no major effects on MMP-13 mRNA levels by the GLP-2 agonists, under either ambient oxygen status; however, there were interesting statistically significant increases in mRNA levels for TIMP 1, 2, and 3 in hypoxic animals treated with GLP-2-MMB, but not native GLP-2 (data not shown).


Positive_regulation (increases) of Transcription (levels) of TIMP associated with hypoxia and agonist
2) Confidence 0.15 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.74 Pain Relevance 0.24
In vivo, however, this was associated with increased collagen I and III depositions and enhanced tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNA expression.
Positive_regulation (enhanced) of Transcription (expression) of TIMP-1 associated with metalloproteinase
3) Confidence 0.11 Published 2001 Journal Hepatology Section Abstract Doc Link 11584368 Disease Relevance 0.88 Pain Relevance 0.52
In vivo, however, this was associated with increased collagen I and III depositions and enhanced tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNA expression.
Positive_regulation (increased) of Transcription (expression) of TIMP-1 associated with metalloproteinase
4) Confidence 0.08 Published 2001 Journal Hepatology Section Abstract Doc Link 11584368 Disease Relevance 0.90 Pain Relevance 0.53

General Comments

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