INT98478

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Context Info
Confidence 0.42
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.29
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lif) extracellular region (Lif)
Anatomy Link Frequency
neurons 2
pituitary 1
Lif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 3 99.84 Very High Very High Very High
Inflammation 35 99.56 Very High Very High Very High
Somatostatin 7 96.24 Very High Very High Very High
substance P 17 95.68 Very High Very High Very High
Dynorphin 1 95.16 Very High Very High Very High
Enkephalin 3 94.72 High High
cytokine 23 92.20 High High
Neuropeptide 7 84.12 Quite High
Neurotransmitter 9 83.00 Quite High
trk B 3 82.88 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 23 99.98 Very High Very High Very High
Stress 53 99.70 Very High Very High Very High
INFLAMMATION 54 99.56 Very High Very High Very High
Apoptosis 48 94.76 High High
Spinal Cord Injury 42 91.32 High High
Leukemia 4 80.52 Quite High
Optic Nerve Injuries 2 67.88 Quite High
Cytomegalovirus Infection 1 30.68 Quite Low
Injury 44 17.36 Low Low
Ganglion Cysts 3 7.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations indicated a specific effect of LIF on nociceptin gene regulation in cultured cortical neurons.
Negative_regulation (effect) of LIF in neurons associated with orphanin
1) Confidence 0.42 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11585557 Disease Relevance 0.16 Pain Relevance 0.45
Our findings suggest that TPS neurons should be particularly sensitive to GDNF, LIF, and CNTF during the first week p.i., and these are the growth factors most likely to be effective in protecting TPS neurons from apoptosis and maintaining a regenerative response within a CNS environment.
Negative_regulation (sensitive) of LIF in neurons associated with apoptosis
2) Confidence 0.24 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.44 Pain Relevance 0.23
LIF is important in mediating the pituitary response to inflammatory stress as transgenic disruption of the LIF gene weakens ACTH secretion (712).
Negative_regulation (disruption) of LIF in pituitary associated with targeted disruption, stress and inflammation
3) Confidence 0.12 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.70 Pain Relevance 0.16

General Comments

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