INT98498

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Context Info
Confidence 0.48
First Reported 2001
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 75
Total Number 76
Disease Relevance 33.67
Pain Relevance 44.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1)
transmembrane transport (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
neurons 6
IB4 5
sensory neurons 3
nociceptors 3
ileum 1
Trpv1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 1746 100.00 Very High Very High Very High
opioid receptor 787 100.00 Very High Very High Very High
antagonist 504 100.00 Very High Very High Very High
Cannabinoid 165 100.00 Very High Very High Very High
ischemia 71 100.00 Very High Very High Very High
sodium channel 25 100.00 Very High Very High Very High
potassium channel 18 100.00 Very High Very High Very High
Nav1.7 15 100.00 Very High Very High Very High
agonist 446 99.96 Very High Very High Very High
Pain 932 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 54 100.00 Very High Very High Very High
Pain 1023 99.84 Very High Very High Very High
Ganglion Cysts 723 99.60 Very High Very High Very High
Erythermalgia 5 99.52 Very High Very High Very High
INFLAMMATION 861 99.40 Very High Very High Very High
Incontinence 5 99.36 Very High Very High Very High
Nociception 397 99.20 Very High Very High Very High
Hyperalgesia 574 98.88 Very High Very High Very High
Hypersensitivity 57 98.76 Very High Very High Very High
Neuropathic Pain 281 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The vanilloid receptor TRPV1 is now recognized as a molecular integrator of painful stimuli ranging from noxious heat to endovanilloids in inflammation.
TRPV1 Binding (recognized) of associated with pain and inflammation
1) Confidence 0.48 Published 2006 Journal Trends Mol Med Section Abstract Doc Link 16996800 Disease Relevance 0.71 Pain Relevance 0.91
TRPV1, which is expressed in sensory neurons innervating the oral cavity, is associated with an oral burning sensation in response to spicy food containing capsaicin.
TRPV1 Binding (associated) of in oral cavity associated with qutenza
2) Confidence 0.48 Published 2010 Journal Neuroscience Section Abstract Doc Link 19958811 Disease Relevance 0 Pain Relevance 0.32
Functional interaction between P2Y receptors and TRPV1 was confirmed in a behavioural analysis using TRPV1-deficient mice.
TRPV1 Binding (interaction) of
3) Confidence 0.48 Published 2004 Journal Novartis Found. Symp. Section Abstract Doc Link 15469041 Disease Relevance 0.24 Pain Relevance 0.51
In order to confirm the specificity of anti-TRPV1 antibody binding, we used TRPV1 deficient mice, which exhibited no staining for TRPV1.
TRPV1 Binding (binding) of
4) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.45 Pain Relevance 0.24
As sensitization of the TRPV1 receptor by mediators of inflammation in damaged tissues has been shown previously, our results suggest that in inflamed, but not in normal tissue, curcumin can interact with the TRPV1 receptor to mediate its protective action in DNBS-induced colitis.
TRPV1 receptor Binding (interact) of associated with colitis and inflammation
5) Confidence 0.48 Published 2007 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17640182 Disease Relevance 0.51 Pain Relevance 0.33
The three capsinoids bound to transient potential vanilloid 1 (TRPV1) receptors expressed in cultured cells and activated Ca(2+) influx in a concentration-dependent manner with similar magnitudes.
TRPV1 Binding (bound) of
6) Confidence 0.48 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 20139632 Disease Relevance 0.08 Pain Relevance 0.54
For example, there is a large degree of overlap between TRPV1 and IB4 binding in rat and very little overlap seen in mouse [12].
TRPV1 Binding (binding) of in IB4
7) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949725 Disease Relevance 0.40 Pain Relevance 0.08
Anandamide is able to bind to TRPV1 proteins at higher concentrations [57].
TRPV1 Binding (bind) of
8) Confidence 0.47 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0.17 Pain Relevance 0.97
Disruption of interaction between phosphatidylinositol-4, 5-bisphosphate (PIP2) and TRPV1 has also been reported to be involved in the sensitization of TRPV1 downstream of PLC activation [45,46].
TRPV1 Binding (interaction) of
9) Confidence 0.47 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.20 Pain Relevance 0.35
In electrophysiological study, whole-cell patch-clamp recordings were performed to investigate the interaction of ET-1 and TRPV1 using human embryonic kidney 293 (HEK293) cells expressing endothelin type A receptor (ET(A)) and TRPV1.
TRPV1 Binding (interaction) of in embryonic kidney
10) Confidence 0.46 Published 2008 Journal Neuroscience Section Abstract Doc Link 18495351 Disease Relevance 0.67 Pain Relevance 0.83
Interestingly, TRPV1 binding was increased in the striatum of DAT KO mice, while CB1 receptor binding was unaffected.
TRPV1 Binding (binding) of in striatum
11) Confidence 0.45 Published 2006 Journal Biol. Psychiatry Section Body Doc Link 16199010 Disease Relevance 0.18 Pain Relevance 0
As already indicated, this was quite obvious for TRPV1, recognized since its discovery as a multimodal transduction molecule for chemical and thermal stimuli [16,22], and more recently to mechanical distension of the bladder [59] and to osmotic stimuli in the hypothalamus [60].
TRPV1 Binding (recognized) of in hypothalamus
12) Confidence 0.43 Published 2008 Journal Mol Pain Section Body Doc Link PMC2386863 Disease Relevance 0 Pain Relevance 0.03
The three capsinoids bound to transient potential vanilloid 1 (TRPV1) receptors expressed in cultured cells and activated Ca(2+) influx in a concentration-dependent manner with similar magnitudes.
vanilloid 1 Binding (bound) of
13) Confidence 0.42 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 20139632 Disease Relevance 0.08 Pain Relevance 0.54
TRPV1 in the urinary system is associated with perception of pain and regulating the micturition reflex.
TRPV1 Binding (associated) of in urinary system associated with pain and overactive bladder
14) Confidence 0.42 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647151 Disease Relevance 1.27 Pain Relevance 0.75
Our results present a novel molecular basis for the anti-inflammatory action of peripheral opioids through a functional interaction of the MOP and PKA-sensitized TRPV1.
TRPV1 Binding (interaction) of associated with inflammation, opioid receptor and opioid
15) Confidence 0.39 Published 2006 Journal Mol Pain Section Body Doc Link PMC1553434 Disease Relevance 0.62 Pain Relevance 1.60
This is the first demonstration of a functional interaction between the TRPV1 and the MOP at the molecular level, and the interaction demonstrated here may be of significance in the treatment of inflammatory pain.
TRPV1 Binding (interaction) of associated with ipn and opioid receptor
16) Confidence 0.39 Published 2006 Journal Mol Pain Section Body Doc Link PMC1553434 Disease Relevance 0.55 Pain Relevance 1.34
However, few studies have investigated pathways that interact with the TRPV1 to prevent sensitization [12,14].
TRPV1 Binding (interact) of
17) Confidence 0.39 Published 2006 Journal Mol Pain Section Body Doc Link PMC1553434 Disease Relevance 0.51 Pain Relevance 0.91
The results presented here support the hypothesis that the MOP and TRPV1 can functionally interact through a cAMP-dependent PKA pathway, as morphine inhibited FSK-potentiated capsaicin responses but not capsaicin responses in the absence of FSK.
TRPV1 Binding (interact) of associated with qutenza, opioid receptor and morphine
18) Confidence 0.39 Published 2006 Journal Mol Pain Section Body Doc Link PMC1553434 Disease Relevance 0.22 Pain Relevance 1.18
As the activation profiles of single molecular sensors do not appear to recapitulate the transduction capacities of single nerve terminals, it seems more likely that discrimination capacity for the adequate stimulus is dictated by a more complex interaction between specific transduction molecules and other ion channel proteins.
channel Binding (interaction) of in nerve
19) Confidence 0.38 Published 2008 Journal Mol Pain Section Body Doc Link PMC2386863 Disease Relevance 0 Pain Relevance 0
In adult rat, 50%–75% of IB4-binding neurons express TRPV1 (Michael and Priestley 1999; Guo et al. 2001; Price and Flores 2007) and 70%–80% of TRPV1-immunoreactive cells bind IB4 (Guo et al. 2001; Price and Flores 2007).
TRPV1 Binding (bind) of in IB4
20) Confidence 0.38 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.08 Pain Relevance 0

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