INT985

Context Info Confidence 0.57 First Reported 1978 Last Reported 2010 Negated 10 Speculated 3 Reported most in Abstract Documents 213 Total Number 217 Disease Relevance 89.53 Pain Relevance 32.39

extracellular space (GH1) extracellular region (GH1)

Anatomy Link Frequency plasma 11 pituitary 9 fat 4 body 4 blood 2 GH1 (Homo sapiens)

Pain Link Frequency Relevance Heat Clonidine 162 100.00 dexamethasone 10 100.00 rheumatoid arthritis 543 99.98 narcan 16 99.98 antidepressant 10 99.76 antagonist 115 99.74 Somatostatin 513 99.64 Acupuncture 12 99.36 Dopamine 356 99.32 gABA 3 99.30

Disease Link Frequency Relevance Heat Body Weight 51 100.00 Rheumatoid Arthritis 543 99.98 Acromegaly 1138 99.96 Syndrome 89 99.90 Renal Failure 31 99.84 Hypoglycemia 112 99.72 Disease 613 99.68 Pituitary Cancer 464 99.66 Growth Problems 564 99.62 Reprotox - General 3 26 99.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

GH treatment in adults with GH deficiency has numerous beneficial effects, but most studies have been small.

Negative_regulation (deficiency) of GH

1) Confidence 0.57 Published 1998 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9435425 Disease Relevance 0.07 Pain Relevance 0

Concerning the influence of metabolic and nutritional factors, an impaired somatotropin response to hypoglycaemia and a failure of glucose load to inhibit spontaneous and stimulated GH release are well documented in obese patients; furthermore, drugs able to block lipolysis and thus to lower serum free fatty acids (NEFA) significantly improve somatotropin secretion in obesity.

Negative_regulation (impaired) of somatotropin associated with hypoglycemia and obesity

2) Confidence 0.57 Published 1999 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 10193871 Disease Relevance 0.95 Pain Relevance 0.08

The clinical usefulness of liquid human growth hormone (hGH) (Norditropin SimpleXx in the treatment of GH deficiency.

Negative_regulation (deficiency) of GH associated with pain

3) Confidence 0.56 Published 1999 Journal Horm. Res. Section Title Doc Link 10592454 Disease Relevance 0 Pain Relevance 0.10

A physiological decrease in growth hormone (GH) and IGF-I secretion accompanies these changes.

Negative_regulation (decrease) of GH

4) Confidence 0.56 Published 1993 Journal Rev Clin Esp Section Abstract Doc Link 8497741 Disease Relevance 0.18 Pain Relevance 0

GH treatment has also been used with encouraging results in adult subjects with isolated or combined GH deficiency.

Negative_regulation (deficiency) of GH

5) Confidence 0.56 Published 1993 Journal Rev Clin Esp Section Abstract Doc Link 8497741 Disease Relevance 0.88 Pain Relevance 0.11

GH administration to elderly individuals has produced an decrease in fat mass and an increase in lean body mass, being this finding consistent with the hypothesis that GH deficiency could be a contributing cause to senescent changes in some elderly individuals.

Negative_regulation (deficiency) of GH in body

6) Confidence 0.56 Published 1993 Journal Rev Clin Esp Section Abstract Doc Link 8497741 Disease Relevance 0.76 Pain Relevance 0.09

In the early 1960s, growth hormone (GH) deficiency was treated by intramuscular injection of GH extracted from human pituitary glands.

Negative_regulation (deficiency) of GH in pituitary glands

7) Confidence 0.56 Published 2001 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 11393569 Disease Relevance 0.07 Pain Relevance 0.07

The sc and im administration of human GH (hGH) was compared in the therapy of GH deficiency.

Negative_regulation (deficiency) of GH

8) Confidence 0.56 Published 1982 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6889608 Disease Relevance 0.07 Pain Relevance 0

Growth parameters and predictors of growth in short children with and without growth hormone (GH) deficiency treated with human GH: a randomized controlled study.

Neg (without) Negative_regulation (deficiency) of GH

9) Confidence 0.55 Published 1996 Journal J. Trop. Pediatr. Section Title Doc Link 8936959 Disease Relevance 0.10 Pain Relevance 0.12

In conclusion NLA and enflurane induced a decrease of GH and PRL plasma levels; in both groups the anaesthetic agents, at the dosage used during anaesthesia, blocked the response of these hormones to the surgical stress likely due to a block of the hypothalamic-pituitary response.

Negative_regulation (decrease) of GH in plasma associated with stress

10) Confidence 0.50 Published 1985 Journal Minerva Med. Section Abstract Doc Link 4069417 Disease Relevance 0.26 Pain Relevance 0.07

A reduction of the growth hormone (GH) response to the alpha(2) adrenergic agonist clonidine is a neuroendocrine abnormality observed with reasonable consistency among human patients with mood and anxiety disorders.

Negative_regulation (reduction) of GH associated with anxiety disorder, agonist and clonidine

11) Confidence 0.50 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 10963795 Disease Relevance 0.09 Pain Relevance 0.22

It has been used to test for GH deficiency in children, to assess central alpha(2)-adrenoceptor function in adults and to determine the pathophysiological basis and to confirm diagnosis in neurological diseases with autonomic failure.

Negative_regulation (deficiency) of GH in autonomic associated with neurological disease

12) Confidence 0.48 Published 2001 Journal Growth Horm. IGF Res. Section Abstract Doc Link 11472079 Disease Relevance 0.09 Pain Relevance 0.40

One patient and one healthy subject had a GH dose reduction.

Negative_regulation (reduction) of GH

13) Confidence 0.48 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0.78 Pain Relevance 0.08

Although she had no overt symptoms of acromegaly, her cardiac function was improved when her GH and IGF-1 levels were reduced as she had less dyspnoea.

Negative_regulation (reduced) of GH associated with acromegaly and dyspnea

14) Confidence 0.45 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2845144 Disease Relevance 0.80 Pain Relevance 0.06

The goals of treatment for acromegaly are to reduce GH levels to <2.5 ng/ml, normalize IGF-1 levels, and/or control tumor mass [6,7].

Negative_regulation (reduce) of GH associated with acromegaly and cancer

15) Confidence 0.45 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2845144 Disease Relevance 0.50 Pain Relevance 0.03

Her GH level was >40 ng/ml and was not suppressed by a standard oral glucose load.

Neg (not) Negative_regulation (suppressed) of GH

16) Confidence 0.45 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2845144 Disease Relevance 0.52 Pain Relevance 0.05

A significative reduction of GH at 60' and of PRL at 30' was observed in both groups.

Negative_regulation (reduction) of GH

17) Confidence 0.44 Published 1985 Journal Minerva Med. Section Abstract Doc Link 4069417 Disease Relevance 0.18 Pain Relevance 0.13

Seventy-four prepubertal patients with documented GH deficiency were randomized to receive sustained release recombinant human GH at either 1.5 mg/kg once monthly or 0.75 mg/kg twice monthly by sc injection in a 6-month open-label study.

Negative_regulation (deficiency) of GH

18) Confidence 0.43 Published 2001 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 11600528 Disease Relevance 0 Pain Relevance 0

The GH deficiency in adults may have arisen i either childhood or during adult life and these two groups differ with regard to history of disease.

Negative_regulation (deficiency) of GH associated with disease

19) Confidence 0.43 Published 1997 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 9196611 Disease Relevance 0.10 Pain Relevance 0

There were 98 patients with adult-onset and 67 patients with childhood-onset GH deficiency.

Negative_regulation (deficiency) of GH

20) Confidence 0.43 Published 1997 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 9196611 Disease Relevance 0 Pain Relevance 0

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