INT985

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Context Info
Confidence 0.57
First Reported 1978
Last Reported 2010
Negated 10
Speculated 3
Reported most in Abstract
Documents 213
Total Number 217
Disease Relevance 89.53
Pain Relevance 32.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GH1) extracellular region (GH1)
Anatomy Link Frequency
plasma 11
pituitary 9
fat 4
body 4
blood 2
GH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 162 100.00 Very High Very High Very High
dexamethasone 10 100.00 Very High Very High Very High
rheumatoid arthritis 543 99.98 Very High Very High Very High
narcan 16 99.98 Very High Very High Very High
antidepressant 10 99.76 Very High Very High Very High
antagonist 115 99.74 Very High Very High Very High
Somatostatin 513 99.64 Very High Very High Very High
Acupuncture 12 99.36 Very High Very High Very High
Dopamine 356 99.32 Very High Very High Very High
gABA 3 99.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
Body Weight 51 100.00 Very High Very High Very High
Rheumatoid Arthritis 543 99.98 Very High Very High Very High
Acromegaly 1138 99.96 Very High Very High Very High
Syndrome 89 99.90 Very High Very High Very High
Renal Failure 31 99.84 Very High Very High Very High
Hypoglycemia 112 99.72 Very High Very High Very High
Disease 613 99.68 Very High Very High Very High
Pituitary Cancer 464 99.66 Very High Very High Very High
Growth Problems 564 99.62 Very High Very High Very High
Reprotox - General 3 26 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GH treatment in adults with GH deficiency has numerous beneficial effects, but most studies have been small.
Negative_regulation (deficiency) of GH
1) Confidence 0.57 Published 1998 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 9435425 Disease Relevance 0.07 Pain Relevance 0
Concerning the influence of metabolic and nutritional factors, an impaired somatotropin response to hypoglycaemia and a failure of glucose load to inhibit spontaneous and stimulated GH release are well documented in obese patients; furthermore, drugs able to block lipolysis and thus to lower serum free fatty acids (NEFA) significantly improve somatotropin secretion in obesity.
Negative_regulation (impaired) of somatotropin associated with hypoglycemia and obesity
2) Confidence 0.57 Published 1999 Journal Int. J. Obes. Relat. Metab. Disord. Section Abstract Doc Link 10193871 Disease Relevance 0.95 Pain Relevance 0.08
The clinical usefulness of liquid human growth hormone (hGH) (Norditropin SimpleXx in the treatment of GH deficiency.
Negative_regulation (deficiency) of GH associated with pain
3) Confidence 0.56 Published 1999 Journal Horm. Res. Section Title Doc Link 10592454 Disease Relevance 0 Pain Relevance 0.10
A physiological decrease in growth hormone (GH) and IGF-I secretion accompanies these changes.
Negative_regulation (decrease) of GH
4) Confidence 0.56 Published 1993 Journal Rev Clin Esp Section Abstract Doc Link 8497741 Disease Relevance 0.18 Pain Relevance 0
GH treatment has also been used with encouraging results in adult subjects with isolated or combined GH deficiency.
Negative_regulation (deficiency) of GH
5) Confidence 0.56 Published 1993 Journal Rev Clin Esp Section Abstract Doc Link 8497741 Disease Relevance 0.88 Pain Relevance 0.11
GH administration to elderly individuals has produced an decrease in fat mass and an increase in lean body mass, being this finding consistent with the hypothesis that GH deficiency could be a contributing cause to senescent changes in some elderly individuals.
Negative_regulation (deficiency) of GH in body
6) Confidence 0.56 Published 1993 Journal Rev Clin Esp Section Abstract Doc Link 8497741 Disease Relevance 0.76 Pain Relevance 0.09
In the early 1960s, growth hormone (GH) deficiency was treated by intramuscular injection of GH extracted from human pituitary glands.
Negative_regulation (deficiency) of GH in pituitary glands
7) Confidence 0.56 Published 2001 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 11393569 Disease Relevance 0.07 Pain Relevance 0.07
The sc and im administration of human GH (hGH) was compared in the therapy of GH deficiency.
Negative_regulation (deficiency) of GH
8) Confidence 0.56 Published 1982 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6889608 Disease Relevance 0.07 Pain Relevance 0
Growth parameters and predictors of growth in short children with and without growth hormone (GH) deficiency treated with human GH: a randomized controlled study.
Neg (without) Negative_regulation (deficiency) of GH
9) Confidence 0.55 Published 1996 Journal J. Trop. Pediatr. Section Title Doc Link 8936959 Disease Relevance 0.10 Pain Relevance 0.12
In conclusion NLA and enflurane induced a decrease of GH and PRL plasma levels; in both groups the anaesthetic agents, at the dosage used during anaesthesia, blocked the response of these hormones to the surgical stress likely due to a block of the hypothalamic-pituitary response.
Negative_regulation (decrease) of GH in plasma associated with stress
10) Confidence 0.50 Published 1985 Journal Minerva Med. Section Abstract Doc Link 4069417 Disease Relevance 0.26 Pain Relevance 0.07
A reduction of the growth hormone (GH) response to the alpha(2) adrenergic agonist clonidine is a neuroendocrine abnormality observed with reasonable consistency among human patients with mood and anxiety disorders.
Negative_regulation (reduction) of GH associated with anxiety disorder, agonist and clonidine
11) Confidence 0.50 Published 2000 Journal Psychiatry Res Section Abstract Doc Link 10963795 Disease Relevance 0.09 Pain Relevance 0.22
It has been used to test for GH deficiency in children, to assess central alpha(2)-adrenoceptor function in adults and to determine the pathophysiological basis and to confirm diagnosis in neurological diseases with autonomic failure.
Negative_regulation (deficiency) of GH in autonomic associated with neurological disease
12) Confidence 0.48 Published 2001 Journal Growth Horm. IGF Res. Section Abstract Doc Link 11472079 Disease Relevance 0.09 Pain Relevance 0.40
One patient and one healthy subject had a GH dose reduction.
Negative_regulation (reduction) of GH
13) Confidence 0.48 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0.78 Pain Relevance 0.08
Although she had no overt symptoms of acromegaly, her cardiac function was improved when her GH and IGF-1 levels were reduced as she had less dyspnoea.
Negative_regulation (reduced) of GH associated with acromegaly and dyspnea
14) Confidence 0.45 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2845144 Disease Relevance 0.80 Pain Relevance 0.06
The goals of treatment for acromegaly are to reduce GH levels to <2.5 ng/ml, normalize IGF-1 levels, and/or control tumor mass [6,7].
Negative_regulation (reduce) of GH associated with acromegaly and cancer
15) Confidence 0.45 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2845144 Disease Relevance 0.50 Pain Relevance 0.03
Her GH level was >40 ng/ml and was not suppressed by a standard oral glucose load.
Neg (not) Negative_regulation (suppressed) of GH
16) Confidence 0.45 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2845144 Disease Relevance 0.52 Pain Relevance 0.05
A significative reduction of GH at 60' and of PRL at 30' was observed in both groups.
Negative_regulation (reduction) of GH
17) Confidence 0.44 Published 1985 Journal Minerva Med. Section Abstract Doc Link 4069417 Disease Relevance 0.18 Pain Relevance 0.13
Seventy-four prepubertal patients with documented GH deficiency were randomized to receive sustained release recombinant human GH at either 1.5 mg/kg once monthly or 0.75 mg/kg twice monthly by sc injection in a 6-month open-label study.
Negative_regulation (deficiency) of GH
18) Confidence 0.43 Published 2001 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 11600528 Disease Relevance 0 Pain Relevance 0
The GH deficiency in adults may have arisen i either childhood or during adult life and these two groups differ with regard to history of disease.
Negative_regulation (deficiency) of GH associated with disease
19) Confidence 0.43 Published 1997 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 9196611 Disease Relevance 0.10 Pain Relevance 0
There were 98 patients with adult-onset and 67 patients with childhood-onset GH deficiency.
Negative_regulation (deficiency) of GH
20) Confidence 0.43 Published 1997 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 9196611 Disease Relevance 0 Pain Relevance 0

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