INT98514

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 13
Disease Relevance 3.83
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC1) transport (ASIC1) plasma membrane (ASIC1)
Anatomy Link Frequency
sensory neurons 2
Mouse 2
ASIC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ASIC 138 100.00 Very High Very High Very High
cINOD 7 99.62 Very High Very High Very High
Abeta 1 99.14 Very High Very High Very High
Inflammation 9 98.76 Very High Very High Very High
substance P 1 97.38 Very High Very High Very High
aspirin 1 97.08 Very High Very High Very High
diclofenac 1 96.72 Very High Very High Very High
Glutamate 12 89.08 High High
nociceptor 5 83.08 Quite High
Pain 17 81.60 Quite High
Disease Link Frequency Relevance Heat
Toxicity 72 99.80 Very High Very High Very High
Death 96 99.76 Very High Very High Very High
Acidosis 49 98.92 Very High Very High Very High
INFLAMMATION 8 98.76 Very High Very High Very High
Apoptosis 12 97.36 Very High Very High Very High
Pain 16 81.60 Quite High
Hyperalgesia 1 79.44 Quite High
Cv Unclassified Under Development 13 77.44 Quite High
Cancer 1 76.68 Quite High
Arthritis 1 76.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar to earlier reports [11,44,45], we found that ASIC1a overexpression significantly increased cell death upon acid treatment (ASIC1a transfected cells: 145.8% ± 14.8%, 164.6% ± 8.9%, 187.0% ± 12.8% for 2, 4, 6 hours respectively. n = 7, * p < 0.05, ** p < 0.01 compared to control groups, Figure 4).
Positive_regulation (overexpression) of Gene_expression (overexpression) of ASIC1a associated with death
1) Confidence 0.57 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.62 Pain Relevance 0
This result indicates that lipid binding is required for PICK1-regulated surface expression of ASIC1a.
Positive_regulation (required) of Gene_expression (expression) of ASIC1a
2) Confidence 0.57 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04
This paper shows (1) that ASIC mRNAs are present in many small sensory neurons along with substance P and isolectin B4 and that, in case of inflammation, ASIC1a appears in some larger Abeta fibers, (2) that NSAIDs prevent the large increase of ASIC expression in sensory neurons induced by inflammation, and (3) that NSAIDs such as aspirin, diclofenac, and flurbiprofen directly inhibit ASIC currents on sensory neurons and when cloned ASICs are heterologously expressed.
Positive_regulation (increase) of Gene_expression (expression) of ASIC in sensory neurons associated with aspirin, inflammation, cinod, diclofenac, abeta, substance p and asic
3) Confidence 0.45 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11588175 Disease Relevance 1.17 Pain Relevance 1.94
Similar to earlier reports [11,44,45], we found that ASIC1a overexpression significantly increased cell death upon acid treatment (ASIC1a transfected cells: 145.8% ± 14.8%, 164.6% ± 8.9%, 187.0% ± 12.8% for 2, 4, 6 hours respectively. n = 7, * p < 0.05, ** p < 0.01 compared to control groups, Figure 4).
Positive_regulation (increased) of Gene_expression (overexpression) of ASIC1a associated with death
4) Confidence 0.41 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.62 Pain Relevance 0
PICK1-regulated surface expression of ASIC1a is dependent on the lipid binding of PICK1's BAR domain
Positive_regulation (dependent) of Gene_expression (expression) of ASIC1a
5) Confidence 0.41 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03
Co-expressing of PICK1 with mouse ASIC1a also increased the population of faster migrating ASIC1a (Figure 1D).
Positive_regulation (increased) of Gene_expression (expressing) of ASIC1a
6) Confidence 0.41 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0
We co-transfected ASIC1a with wild-type PICK1 or BAR-domain mutant PICK1 2K-E into HEK293T cells.
Positive_regulation (transfected) of Gene_expression (transfected) of ASIC1a
7) Confidence 0.41 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.03
Mouse ASIC1a was co-transfected with eGFP or GFP-PICK1.
Positive_regulation (transfected) of Gene_expression (transfected) of ASIC1a in Mouse
8) Confidence 0.41 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.17 Pain Relevance 0
It is possible to change surface levels of ASIC1a and thus ASIC1a-mediated acidotoxicity, by perturbing either the protein-protein interaction or protein-lipid interaction, for instance, via protein kinase or lipid kinase pathways.
Spec (possible) Positive_regulation (change) of Gene_expression (levels) of ASIC1a
9) Confidence 0.38 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.32 Pain Relevance 0.10
Both the PDZ and BAR domains are required for PICK1's effect on surface expression of ASIC1a, we therefore asked if the PDZ and BAR domain mutants abolish the potentiation effect of PICK1 on acid-induced cell death.
Positive_regulation (required) of Gene_expression (expression) of ASIC1a associated with death
10) Confidence 0.38 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.45 Pain Relevance 0
We therefore asked whether the effect of PICK1 on ASIC1a surface expression is also dependent on the BAR domain of PICK1.
Spec (whether) Positive_regulation (dependent) of Gene_expression (expression) of ASIC1a
11) Confidence 0.38 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04
We transfected ASIC1a, with or without PICK1, into COS7 cells.
Positive_regulation (transfected) of Gene_expression (transfected) of ASIC1a
12) Confidence 0.36 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.48 Pain Relevance 0
In contrast to wild-type PICK1, when PICK 2K-E mutant was co-transfected with ASIC1a in 293T cells, we did not observe any cluster formation (Figure 2C).
Positive_regulation (transfected) of Gene_expression (transfected) of ASIC1a
13) Confidence 0.36 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0

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