INT9852

Context Info Confidence 0.70 First Reported 1982 Last Reported 2011 Negated 30 Speculated 13 Reported most in Abstract Documents 563 Total Number 576 Disease Relevance 364.64 Pain Relevance 146.82

biosynthetic process (Gpt) cytoplasm (Gpt)

Anatomy Link Frequency liver 82 plasma 50 blood 8 fat 7 upper 7 Gpt (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 2711 100.00 ischemia 560 100.00 Glutamate 49 100.00 headache 214 99.92 Pain 457 99.88 anesthesia 146 99.88 Inflammation 1139 99.72 isoflurane 47 99.70 ketamine 18 99.66 diclofenac 90 99.58

Disease Link Frequency Relevance Heat Injury 2405 100.00 Cv Unclassified Under Development 742 100.00 Apoptosis 551 100.00 Death 415 100.00 Poisoning 196 100.00 Urological Neuroanatomy 147 100.00 Disorders Of Creatine Metabolism 96 100.00 Rupture 13 100.00 Rickettsiaceae Infection 72 99.98 Hepatotoxicity 1418 99.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Dosages of at least 12 mg/kg were required to prevent the increase in alanine transaminase (ALT) and only the 24 mg/kg hindered the appearance of histological lesions.

Positive_regulation (increase) of alanine transaminase

1) Confidence 0.70 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2353130 Disease Relevance 0.40 Pain Relevance 0.39

Dosages of at least 12 mg/kg were required to prevent the increase in alanine transaminase (ALT) and only the 24 mg/kg hindered the appearance of histological lesions.

Positive_regulation (increase) of ALT

2) Confidence 0.70 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2353130 Disease Relevance 0.40 Pain Relevance 0.39

When acetaminophen (250 mg/kg) was injected intraperitoneally in B6C3F1 mice, the plasma GPT activity was significantly increased by 93 or 107-fold at 6 h or 24 h after the drug injection.

Positive_regulation (increased) of GPT in plasma associated with paracetamol

3) Confidence 0.70 Published 1995 Journal Toxicol. Lett. Section Abstract Doc Link 8553366 Disease Relevance 0.48 Pain Relevance 0.49

Oral administration of lovastatin in corn oil 30 mg/kg three times a week and acetaminophen 0.75% w/v in drinking water for 13 weeks resulted in significant increase in SGPT (ALT) in both male and female mice.

Positive_regulation (increase) of ALT associated with paracetamol

4) Confidence 0.70 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2236904 Disease Relevance 0.35 Pain Relevance 0.35

If, additionally, methotrexate is applied, there is an increase in the death rate, as well as in glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT) activities.

Positive_regulation (increase) of GPT associated with glutamate, methotrexate and death

5) Confidence 0.69 Published 1999 Journal Gen. Pharmacol. Section Abstract Doc Link 10461859 Disease Relevance 0.37 Pain Relevance 0.50

If, additionally, methotrexate is applied, there is an increase in the death rate, as well as in glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT) activities.

Positive_regulation (increase) of glutamate-pyruvate transaminase associated with glutamate, methotrexate and death

6) Confidence 0.69 Published 1999 Journal Gen. Pharmacol. Section Abstract Doc Link 10461859 Disease Relevance 0.37 Pain Relevance 0.50

Thus, inhibition of mitochondrial respiration preceded overt hepatic necrosis, indicated by an elevation of ALT activity, which was not observed until 3 and 4 h post-dosing.

Positive_regulation (elevation) of ALT associated with necrosis

7) Confidence 0.69 Published 1994 Journal Arch. Toxicol. Section Abstract Doc Link 8179480 Disease Relevance 0.33 Pain Relevance 0.34

Treatment of mice with a toxic dose of acetaminophen (300 mg/kg, ip) significantly increased hepatotoxicity at 4 h, as evidenced by histological necrosis in the centrilobular areas of the liver, and increased serum levels of alanine aminotransferase (ALT) (from 8 +/- 1 IU/L in saline-treated mice to 3226 +/- 892 IU/L in the acetaminophen-treated mice).

Positive_regulation (increased) of ALT in liver associated with necrosis, paracetamol and hepatotoxicity

8) Confidence 0.69 Published 1998 Journal Chem. Res. Toxicol. Section Abstract Doc Link 9625727 Disease Relevance 0.20 Pain Relevance 0.35

Activity of ALT was non-significantly increased three hours after TBE and K/X, but not PB administration.

Neg (not) Positive_regulation (increased) of ALT

9) Confidence 0.69 Published 2002 Journal Comp. Med. Section Abstract Doc Link 11900415 Disease Relevance 0.42 Pain Relevance 0.33

The gpt gene MFs were significantly increased in the lungs of gpt delta mice with C60 and kaolin, but not CB administrations.

Neg (not) Positive_regulation (increased) of gpt gene in lungs

10) Confidence 0.69 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2745356 Disease Relevance 0.30 Pain Relevance 0

A 2.1-fold increase of GOT and a 1.9-fold increase of GPT activities (P < 0.001) were observed in mice treated perorally with 500 mg/kg of AAP plus 150 mg/kg of thalidomide (Thal).

Positive_regulation (increase) of GPT associated with paracetamol

11) Confidence 0.68 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7590113 Disease Relevance 0.25 Pain Relevance 0.67

GPT activity and MDA level were markedly increased at 24 hours post-treatment with AAP.

Positive_regulation (increased) of GPT associated with paracetamol

12) Confidence 0.68 Published 2000 Journal Anticancer Res. Section Abstract Doc Link 10928074 Disease Relevance 0.25 Pain Relevance 0.35

Propoxyphene and morphine lowered hepatic glutathione and increased serum glutamic-pyruvic transaminase (SGPT) activity when administered to male mice.

Positive_regulation (increased) of serum glutamic-pyruvic transaminase associated with morphine

13) Confidence 0.68 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7086683 Disease Relevance 0.16 Pain Relevance 0.45

Acetaminophen (300 mg/kg) increased serum nitrate/nitrite and alanine aminotransferase (ALT) levels, indicating increased NO synthesis and liver necrosis, respectively.

Positive_regulation (increased) of ALT in liver associated with paracetamol and hepatotoxicity

14) Confidence 0.67 Published 2002 Journal Nitric Oxide Section Abstract Doc Link 11890740 Disease Relevance 0.35 Pain Relevance 0.57

Intragastric administration of methoxsalen (125 mumol X kg-1), 30 min before that of acetaminophen (600 mg X kg-1 i.p.), decreased the formation of the mercapturate and cysteine conjugates of acetaminophen, the depletion of glutathione and the in vivo covalent binding of an acetaminophen metabolite to hepatic proteins and prevented the increase in serum glutamic-pyruvic transaminase activity, the appearance of liver lesions and mortality.

Positive_regulation (increase) of glutamic-pyruvic transaminase in liver associated with paracetamol

15) Confidence 0.67 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3772810 Disease Relevance 0.24 Pain Relevance 0.65

Administration of L-carnitine significantly reduced AA-induced elevations in AST, ALT, TSA and MDA concentrations and increased GSH levels at all sampling points.

Positive_regulation (elevations) of ALT associated with paracetamol

16) Confidence 0.67 Published 2007 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 17716880 Disease Relevance 0.73 Pain Relevance 1.07

Solanum alatum treatment (100 mg/kg, p.o.) decreased the elevation of serum alanine aminotransferase (ALT; GPT) and aspartate aminotransferase (AST; GOT) induced by acetaminophen (paracetamol) (600 mg/kg, i.p.) administration.

Positive_regulation (elevation) of ALT associated with paracetamol

17) Confidence 0.67 Published 2000 Journal Am. J. Chin. Med. Section Abstract Doc Link 10794122 Disease Relevance 0.26 Pain Relevance 0.45

Mild elevation of liver enzymes (AST and ALT elevated >1-fold in 81% and 75%, respectively) was the most frequent laboratory finding.

Positive_regulation (elevation) of ALT in liver

18) Confidence 0.67 Published 2007 Journal Eur. J. Clin. Microbiol. Infect. Dis. Section Abstract Doc Link 17554571 Disease Relevance 0.96 Pain Relevance 0.10

RESULT: Administration of large doses of paracetamol to C57BL/6J mice produced significant hepatic injury with marked elevation in serum ALT activity and severe hepatocellular necrosis.

Positive_regulation (elevation) of ALT

19) Confidence 0.67 Published 2001 Journal Zhongguo Zhong Yao Za Zhi Section Body Doc Link 12776431 Disease Relevance 0 Pain Relevance 0

Plasma alanine aminotransferase (ALT) levels were increased 2 and 4 h after APAP administration when compared to vehicle (VEH) controls.

Positive_regulation (increased) of ALT in Plasma associated with paracetamol

20) Confidence 0.67 Published 2004 Journal Toxicol. Lett. Section Abstract Doc Link 15501608 Disease Relevance 0.47 Pain Relevance 1.26

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