INT98521

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Context Info
Confidence 0.74
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 52
Total Number 69
Disease Relevance 23.45
Pain Relevance 35.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn2)
Anatomy Link Frequency
neurons 10
DRG 7
oocytes 3
BCs 2
soleus 2
Accn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 2118 100.00 Very High Very High Very High
Dorsal horn 6 99.84 Very High Very High Very High
trigeminal ganglion 142 99.72 Very High Very High Very High
ischemia 956 99.64 Very High Very High Very High
Pain 114 99.54 Very High Very High Very High
Inflammation 24 99.54 Very High Very High Very High
Hippocampus 200 99.28 Very High Very High Very High
Dorsal horn neuron 30 99.20 Very High Very High Very High
dorsal root ganglion 21 98.24 Very High Very High Very High
TRP channel 4 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 226 99.72 Very High Very High Very High
Cv Unclassified Under Development 889 99.64 Very High Very High Very High
INFLAMMATION 15 99.54 Very High Very High Very High
Acidosis 219 99.08 Very High Very High Very High
Injury 109 97.12 Very High Very High Very High
Nociception 152 96.08 Very High Very High Very High
Brain Hemorrhage 63 94.32 High High
Apoptosis 75 94.08 High High
Death 135 93.52 High High
Epilepsy 72 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reverse transcriptase-nested PCR and Western blotting showed that three ASIC isoforms, ASIC1a, ASIC2a, and ASIC2b, are expressed at a high level in dorsal horn neurons.
Gene_expression (expressed) of ASIC2a in neurons associated with dorsal horn neuron and asic
1) Confidence 0.74 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15302881 Disease Relevance 0.24 Pain Relevance 0.70
Reverse transcriptase-nested PCR and Western blotting showed that three ASIC isoforms, ASIC1a, ASIC2a, and ASIC2b, are expressed at a high level in dorsal horn neurons.
Gene_expression (expressed) of ASIC2b in neurons associated with dorsal horn neuron and asic
2) Confidence 0.74 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15302881 Disease Relevance 0.24 Pain Relevance 0.70
Furthermore, peripheral complete Freund's adjuvant-induced inflammation resulted in increased expression of both ASIC1a and ASIC2a in dorsal horn.
Gene_expression (expression) of ASIC2a in dorsal horn associated with inflammation and dorsal horn
3) Confidence 0.74 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15302881 Disease Relevance 0.24 Pain Relevance 0.86
Furthermore, peripheral complete Freund's adjuvant-induced inflammation resulted in increased expression of both ASIC1a and ASIC2a in dorsal horn.
Gene_expression (expression) of ASIC1a in dorsal horn associated with inflammation and dorsal horn
4) Confidence 0.74 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15302881 Disease Relevance 0.24 Pain Relevance 0.86
Reverse transcriptase-nested PCR and Western blotting showed that three ASIC isoforms, ASIC1a, ASIC2a, and ASIC2b, are expressed at a high level in dorsal horn neurons.
Gene_expression (expressed) of ASIC1a in neurons associated with dorsal horn neuron and asic
5) Confidence 0.74 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15302881 Disease Relevance 0.24 Pain Relevance 0.70
Western blotting and immunofluorescence confirmed the expression of ASIC1, ASIC2a, ASIC3, and TRPV1 in cultured and in situ astrocytes.
Gene_expression (expression) of ASIC2a in astrocytes
6) Confidence 0.73 Published 2010 Journal Glia Section Abstract Doc Link 20549751 Disease Relevance 0 Pain Relevance 0.22
Western blotting and immunofluorescence confirmed the expression of ASIC1, ASIC2a, ASIC3, and TRPV1 in cultured and in situ astrocytes.
Gene_expression (expression) of ASIC1 in astrocytes
7) Confidence 0.73 Published 2010 Journal Glia Section Abstract Doc Link 20549751 Disease Relevance 0 Pain Relevance 0.22
The expression of ASIC1a mRNA and protein in rat articular chondrocytes was evaluated by reverse transcriptase polymerase chain reaction (RT-PCR) and Western blotting.
Gene_expression (expression) of ASIC1a in chondrocytes
8) Confidence 0.68 Published 2010 Journal Mol. Cell. Biochem. Section Abstract Doc Link 20179994 Disease Relevance 0.23 Pain Relevance 0.17
The cell injury following acid exposure was analyzed with lactate dehydrogenase release assay and electron microscopy. mRNA and protein expression showed that ASIC1a was expressed abundantly in these cells.
Gene_expression (expressed) of ASIC1a associated with injury
9) Confidence 0.68 Published 2010 Journal Mol. Cell. Biochem. Section Abstract Doc Link 20179994 Disease Relevance 0.36 Pain Relevance 0.12
Reverse transcriptase-nested PCR and Western blotting showed that three ASIC isoforms, ASIC1a, ASIC2a, and ASIC2b, are expressed at a high level in dorsal horn neurons.
Gene_expression (expressed) of ASIC in neurons associated with dorsal horn neuron and asic
10) Confidence 0.50 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15302881 Disease Relevance 0.24 Pain Relevance 0.70
Of note, ZOL reduced the expression of ASIC1a and ASIC1b.
Gene_expression (expression) of ASIC1a
11) Confidence 0.39 Published 2007 Journal J. Bone Miner. Metab. Section Abstract Doc Link 17323179 Disease Relevance 1.03 Pain Relevance 0.66
Of note, ZOL reduced the expression of ASIC1a and ASIC1b.
Gene_expression (expression) of ASIC1b
12) Confidence 0.39 Published 2007 Journal J. Bone Miner. Metab. Section Abstract Doc Link 17323179 Disease Relevance 1.03 Pain Relevance 0.66
The expression of ASIC1a and ASIC1b was increased in the ipsilateral DRGs, whereas the ASIC3 and TRPV1 expression was not changed.
Gene_expression (expression) of ASIC1a in DRGs associated with ganglion cysts
13) Confidence 0.39 Published 2007 Journal J. Bone Miner. Metab. Section Abstract Doc Link 17323179 Disease Relevance 1.15 Pain Relevance 0.73
The expression of ASIC1a and ASIC1b was increased in the ipsilateral DRGs, whereas the ASIC3 and TRPV1 expression was not changed.
Gene_expression (expression) of ASIC1b in DRGs associated with ganglion cysts
14) Confidence 0.39 Published 2007 Journal J. Bone Miner. Metab. Section Abstract Doc Link 17323179 Disease Relevance 1.15 Pain Relevance 0.73
ASIC2b, ASIC3, and ASIC4 were expressed to a lesser degree in vestibular ganglion neurons.
Gene_expression (expressed) of ASIC2b in neurons associated with ganglion cysts
15) Confidence 0.39 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16790596 Disease Relevance 0.25 Pain Relevance 0.36
There is no other information about the co-expression of TRPV1, ASIC and P2X receptors in afferents from the masseter muscle, although a relatively limited co-expression of TRPV1 and P2X3 receptors has been reported in gastrocnemius-soleus muscle afferents [16].
Gene_expression (expression) of ASIC in soleus associated with asic
16) Confidence 0.29 Published 2005 Journal Mol Pain Section Body Doc Link PMC1283980 Disease Relevance 0.05 Pain Relevance 0.74
Only 4/55 (7%) of neurons failed to express one of either TRPV1, ASIC or P2X3-like current (Figure 5a).
Neg (failed) Gene_expression (express) of ASIC in neurons associated with asic
17) Confidence 0.29 Published 2005 Journal Mol Pain Section Body Doc Link PMC1283980 Disease Relevance 0.48 Pain Relevance 0.10
Our findings that about 50% of TRPV1 containing masseter afferents also expressed ASIC channels, and 30% of ASIC expressing afferents expressed TRPV1 are consistent with these results.
Gene_expression (expressed) of ASIC in masseter associated with asic
18) Confidence 0.25 Published 2005 Journal Mol Pain Section Body Doc Link PMC1283980 Disease Relevance 0 Pain Relevance 0.76
There is no other information about the co-expression of TRPV1, ASIC and P2X receptors in afferents from the masseter muscle, although a relatively limited co-expression of TRPV1 and P2X3 receptors has been reported in gastrocnemius-soleus muscle afferents [16].
Gene_expression (expression) of ASIC in soleus associated with asic
19) Confidence 0.25 Published 2005 Journal Mol Pain Section Body Doc Link PMC1283980 Disease Relevance 0.05 Pain Relevance 0.74
Nevertheless, it is yet unknown why the Hill coefficient (0.9) of the ASIC activation curve in NG2 cells is relatively low compared to the reported value (1.64) for recombinant ASIC1a homomers expressed in Xenopus oocytes [33].
Gene_expression (expressed) of ASIC1a in oocytes associated with asic
20) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.50

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