INT98522

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 68
Total Number 78
Disease Relevance 26.95
Pain Relevance 28.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn3) cytoplasm (Accn3)
Anatomy Link Frequency
neurons 13
muscle 12
sensory neurons 7
vasculature 3
afferent neurons 3
Accn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 573 100.00 Very High Very High Very High
nociceptor 323 99.92 Very High Very High Very High
Calcitonin gene-related peptide 28 99.76 Very High Very High Very High
spinal dorsal horn 12 99.68 Very High Very High Very High
Peripheral nervous system 6 99.68 Very High Very High Very High
dorsal root ganglion 446 99.66 Very High Very High Very High
Pain 632 99.60 Very High Very High Very High
trigeminal ganglion 181 99.56 Very High Very High Very High
Inflammation 80 99.56 Very High Very High Very High
Action potential 70 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ischemic Heart Disease 5 100.00 Very High Very High Very High
Ganglion Cysts 811 99.72 Very High Very High Very High
Nociception 605 99.60 Very High Very High Very High
Pain 471 99.60 Very High Very High Very High
INFLAMMATION 63 99.56 Very High Very High Very High
Myalgia 67 99.28 Very High Very High Very High
Targeted Disruption 125 99.24 Very High Very High Very High
Cv General 3 Under Development 45 99.00 Very High Very High Very High
Neuropathic Pain 34 98.84 Very High Very High Very High
Hyperalgesia 38 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acid-sensing ion channel 3 (ASIC3) is highly expressed on sensory neurons that innervate heart and skeletal muscle and, therefore, is proposed to detect lactic acidosis and to transduce angina and muscle ischemic pain.
Gene_expression (expressed) of ASIC3 in muscle associated with pain, angina and lactic acidosis
1) Confidence 0.78 Published 2006 Journal Circ. Res. Section Abstract Doc Link 16873722 Disease Relevance 0.50 Pain Relevance 0.33
In addition, expressions of P2X(3) and ASIC3 also increased in muscle afferent neurons in DRGs.
Gene_expression (expressions) of ASIC3 in afferent neurons
2) Confidence 0.75 Published 2010 Journal Pain Section Abstract Doc Link 20378247 Disease Relevance 0.91 Pain Relevance 0.99
Expressions of TRPV2, P2X(3), and ASIC3 increased in all DRG neurons.
Gene_expression (Expressions) of ASIC3 in neurons associated with dorsal root ganglion
3) Confidence 0.75 Published 2010 Journal Pain Section Abstract Doc Link 20378247 Disease Relevance 0.92 Pain Relevance 0.99
Expressions of the ion channels TRPV1, TRPV2, P2X(3) and ASIC3 were examined in dorsal root ganglion (DRG) neurons and the muscle afferent neurons innervating GM.
Spec (examined) Gene_expression (Expressions) of ASIC3 in afferent neurons associated with ganglion cysts and dorsal root ganglion
4) Confidence 0.75 Published 2010 Journal Pain Section Abstract Doc Link 20378247 Disease Relevance 0.83 Pain Relevance 0.80
The current carried by heterologously expressed ASIC1a and ASIC3 was also potentiated by AA.
Gene_expression (expressed) of ASIC3
5) Confidence 0.75 Published 2007 Journal Neuroscience Section Abstract Doc Link 17258862 Disease Relevance 0.38 Pain Relevance 0.44
In this study, we report that another mammalian peptide neuropeptide SF (NPSF), derived from the same precursor, also considerably increases the amplitude of the sustained current of heterologously expressed ASIC3 (12-fold vs. 19- and nine-fold for FMRFamide and NPFF, respectively) with an EC(50) of approximately 50 microM.
Gene_expression (expressed) of ASIC3 associated with neuropeptide
6) Confidence 0.75 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12668052 Disease Relevance 0.25 Pain Relevance 0.36
ASIC3-mediated sustained depolarisation, and its regulation by neuropeptides, could thus be important in regulating polymodal neuron excitability particularly under inflammatory conditions where the expression levels of both NPFF precursor and ASIC3 are increased.
Gene_expression (expression) of ASIC3 in polymodal neuron associated with inflammation and neuropeptide
7) Confidence 0.75 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12668052 Disease Relevance 0.20 Pain Relevance 0.35
ASIC2b, ASIC3, and ASIC4 were expressed to a lesser degree in vestibular ganglion neurons.
Gene_expression (expressed) of ASIC3 in neurons associated with ganglion cysts
8) Confidence 0.74 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16790596 Disease Relevance 0.25 Pain Relevance 0.35
The co-expression of ASIC3 with calcitonin gene-related peptide (CGRP) or parvalbumin (PV) was examined in the trigeminal ganglion (TG) by a double immunofluorescence method.
Gene_expression (co-expression) of ASIC3 in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion and calcitonin gene-related peptide
9) Confidence 0.70 Published 2002 Journal Brain Res. Section Abstract Doc Link 12101052 Disease Relevance 0.47 Pain Relevance 0.44
The co-expression of ASIC3 with calcitonin gene-related peptide and parvalbumin in the rat trigeminal ganglion.
Gene_expression (co-expression) of ASIC3 in trigeminal ganglion associated with ganglion cysts, nociceptor, trigeminal ganglion and calcitonin gene-related peptide
10) Confidence 0.70 Published 2002 Journal Brain Res. Section Title Doc Link 12101052 Disease Relevance 0.65 Pain Relevance 0.81
Figure 5 shows that small muscle afferents are more likely to express ASIC3 than are small skin afferents.
Gene_expression (express) of ASIC3 in muscle
11) Confidence 0.69 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.31 Pain Relevance 0.38
Whether they have small diameters or large, most muscle afferents (83%, 168/173) that express ASIC3 also express the vasodilatory peptide, CGRP.
Gene_expression (express) of ASIC3 in muscle
12) Confidence 0.69 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.06 Pain Relevance 0.10
fibers because they express NF200, a marker of myelinated axons [43], whereas we saw no evidence that CGRP-positive small-caliber (C) arterial axons express ASIC3 or TRPV1.
Gene_expression (express) of ASIC3
13) Confidence 0.69 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.52 Pain Relevance 0.27
Importantly, many sensory axons that innervate small arteries express ASIC3 together with CGRP and TRPV1.
Gene_expression (express) of ASIC3
14) Confidence 0.69 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.46 Pain Relevance 0.28
ASIC3 and CGRP co-express on sensory endings innervating blood vessels
Gene_expression (co-express) of ASIC3 in blood vessels
15) Confidence 0.69 Published 2005 Journal Mol Pain Section Body Doc Link PMC1308857 Disease Relevance 0.12 Pain Relevance 0.17
Acid-sensing ion channel 3 (ASIC3) is highly expressed on sensory neurons that innervate heart and skeletal muscle and, therefore, is proposed to detect lactic acidosis and to transduce angina and muscle ischemic pain.
Gene_expression (expressed) of Acid-sensing ion channel 3 in muscle associated with pain, angina and lactic acidosis
16) Confidence 0.68 Published 2006 Journal Circ. Res. Section Abstract Doc Link 16873722 Disease Relevance 0.50 Pain Relevance 0.33
Here, we show that ASIC3 (acid-sensing ion channel #3) has the appropriate expression pattern and physical properties to be the detector of this lactic acid.
Gene_expression (expression) of ASIC3
17) Confidence 0.68 Published 2005 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 16258623 Disease Relevance 0.58 Pain Relevance 0.42
Both, TRPV1 and ASIC3, are expressed by subsets of primary afferent neurons and are the major acid-sensitive ion channels of sensory neurons know so far [17-19].
Gene_expression (expressed) of ASIC3 in afferent neurons
18) Confidence 0.66 Published 2006 Journal Respir Res Section Body Doc Link PMC1524950 Disease Relevance 0.48 Pain Relevance 0.22
Expression of at least one acid-sensitive channel, TRPV1 or ASIC3, is a major characteristic of spinal thoracic pleural afferents, since only 3% of retrogradely labelled neurons contained neither TRPV1- nor ASIC3-immunoreactivity.
Gene_expression (Expression) of ASIC3 in spinal
19) Confidence 0.66 Published 2006 Journal Respir Res Section Body Doc Link PMC1524950 Disease Relevance 0 Pain Relevance 0.04
These relative proportions might be a slight overestimation of the situation under physiological conditions, since tracer application caused, to some extent, local inflammation, and inflammatory conditions lead to increased ASIC3 transcription in vivo and to an increased number of ASIC3 expressing neurons in vitro [46,47].
Gene_expression (expressing) of ASIC3 in neurons associated with inflammation
20) Confidence 0.66 Published 2006 Journal Respir Res Section Body Doc Link PMC1524950 Disease Relevance 0.42 Pain Relevance 0.43

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