INT98524

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 19
Disease Relevance 9.48
Pain Relevance 11.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn2)
Anatomy Link Frequency
brain 4
neurons 3
spinal 1
muscle 1
Accn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 780 100.00 Very High Very High Very High
Pain 37 100.00 Very High Very High Very High
Inflammation 12 100.00 Very High Very High Very High
gABA 15 99.96 Very High Very High Very High
ischemia 472 99.64 Very High Very High Very High
Dorsal horn neuron 3 99.56 Very High Very High Very High
central sensitization 9 99.28 Very High Very High Very High
dorsal root ganglion 1 98.56 Very High Very High Very High
c fibre 3 98.36 Very High Very High Very High
Stimulus evoked pain 3 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 464 99.64 Very High Very High Very High
Ganglion Cysts 37 98.56 Very High Very High Very High
Inflammatory Pain 6 98.16 Very High Very High Very High
Brain Injury 5 97.96 Very High Very High Very High
Hypersensitivity 9 97.44 Very High Very High Very High
Pain 26 96.12 Very High Very High Very High
Acidosis 236 95.88 Very High Very High Very High
Nociception 35 95.72 Very High Very High Very High
Demyelinating Disease 10 95.20 Very High Very High Very High
Apoptosis 40 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immediately after global ischemia, the extracellular pH of the brain decreases from 7.2 to 6.5, a level sufficiently low to activate ASIC 1a and ASIC1a/ASIC 2a comprising channels [7].
Positive_regulation (activate) of ASIC in brain associated with ischemia and asic
1) Confidence 0.49 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.58 Pain Relevance 0.69
Thus it seems that a significant proportion of muscle afferents involved in producing activity-induced cardiovascular reflexes, perhaps mediated by activation of ASIC channels, also express TRPV1.
Positive_regulation (activation) of ASIC in muscle associated with asic
2) Confidence 0.22 Published 2005 Journal Mol Pain Section Body Doc Link PMC1283980 Disease Relevance 0 Pain Relevance 0.73
We thus examined whether activation of ASIC channels leads to [Ca2+]i elevation in NG2 cells (Fig. 5A).
Spec (whether) Positive_regulation (activation) of ASIC associated with asic
3) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.18
Functional activation of ASIC1a channels leads to marked membrane depolarization and an increase in intracellular Ca2+.
Positive_regulation (activation) of ASIC1a
4) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0.57 Pain Relevance 0.29
Moreover, in vivo electrophysiological recording showed that the elevated ASIC1a activity is required for two forms of central sensitization: C-fiber-induced "wind-up" and CFA-induced hypersensitivity of SDH nociceptive neurons.
Positive_regulation (elevated) of ASIC1a in neurons associated with nociception, c fibre, central sensitization, spinal dorsal horn and hypersensitivity
5) Confidence 0.21 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17928456 Disease Relevance 0.74 Pain Relevance 1.22
Moreover, in vivo electrophysiological recording showed that the elevated ASIC1a activity is required for two forms of central sensitization: C-fiber-induced "wind-up" and CFA-induced hypersensitivity of SDH nociceptive neurons.
Positive_regulation (required) of ASIC1a in neurons associated with nociception, c fibre, central sensitization, spinal dorsal horn and hypersensitivity
6) Confidence 0.21 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17928456 Disease Relevance 0.74 Pain Relevance 1.23
By analogy with the depolarizing GABA, activation of ASIC1a channels in NG2 cells by protons might cause membrane depolarization, thereby contributing to the production of BDNF and other neurotrophic factors through Ca2+-dependent mechanisms [3].
Positive_regulation (activation) of ASIC1a associated with gaba
7) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0.79 Pain Relevance 0.35
Activation of ASIC1a homomers is known to increase intracellular Ca2+ [17], [18].
Positive_regulation (Activation) of ASIC1a
8) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.23
80 mV) in the presence of TTX (1 µM), gabazine (1 µM) and kynurenic acid (2 mM) induced an ASIC current (black trace, 308±72 pA, n?
Positive_regulation (induced) of ASIC associated with asic
9) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.16
We found that global ischemia induced a marked increase in ASIC 2a mRNA within three hours of ischemia.
Positive_regulation (increase) of ASIC associated with ischemia and asic
10) Confidence 0.14 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.69 Pain Relevance 0.52
We also found that preconditioning increased the ASIC 2a mRNA and protein to a level higher than that induced by a single ischemic insult.
Positive_regulation (increased) of ASIC associated with asic
11) Confidence 0.14 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.93 Pain Relevance 0.56
Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity.
Positive_regulation (Upregulation) of ASIC1a in spinal associated with inflammation, hypersensitivity, stimulus evoked pain, inflammatory pain and dorsal horn neuron
12) Confidence 0.14 Published 2007 Journal J. Neurosci. Section Title Doc Link 17928456 Disease Relevance 0.68 Pain Relevance 1.49
In situ hybridization showed that ASIC-beta2 mRNA was concentrated in both small diameter and large diameter neurons and co-localized with ASIC-beta mRNA within single sensory neurons in the trigeminal ganglion.
Positive_regulation (concentrated) of ASIC-beta2 mRNA in neurons associated with ganglion cysts, trigeminal ganglion and asic
13) Confidence 0.13 Published 2001 Journal Neuroreport Section Abstract Doc Link 11588592 Disease Relevance 0.38 Pain Relevance 0.67
In addition, RT-PCR and western blot analysis showed the preconditioning followed by an ischemic event significantly increased the ASIC 2a mRNA and protein expression when compared to a single ischemic insult (p < 0.01, Figures 3, 4).
Positive_regulation (increased) of ASIC associated with asic
14) Confidence 0.10 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.90 Pain Relevance 0.50
Immediately after global ischemia, the extracellular pH of the brain decreases from 7.2 to 6.5, a level sufficiently low to activate ASIC 1a and ASIC1a/ASIC 2a comprising channels [7].
Positive_regulation (activate) of ASIC in brain associated with ischemia and asic
15) Confidence 0.10 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.58 Pain Relevance 0.69
Immediately after global ischemia, the extracellular pH of the brain decreases from 7.2 to 6.5, a level sufficiently low to activate ASIC 1a and ASIC1a/ASIC 2a comprising channels [7].
Positive_regulation (activate) of ASIC in brain associated with ischemia and asic
16) Confidence 0.09 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.57 Pain Relevance 0.69
Preconditioning prior to the ischemic insult significantly up-regulated ASIC 2a mRNA compared to the ischemic insult alone (p < 0.01 at 24 h and p < 0.05 at 12 or 72 h, Figure 3).
Positive_regulation (regulated) of ASIC associated with asic
17) Confidence 0.09 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.61 Pain Relevance 0.57
We also found that preconditioning increased the ASIC 2a mRNA and protein to a level higher than that induced by a single ischemic insult.
Positive_regulation (increased) of ASIC associated with asic
18) Confidence 0.09 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.53 Pain Relevance 0.27
The ion selectivity of these channels is not restricted to Na+; ASIC1a is also permeable to Ca2+ [19, 99, 105, 110] and contributes to the Ca2+ overload in neurones of ischaemic brain [107].
Positive_regulation (contributes) of ASIC1a in brain
19) Confidence 0.01 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.18 Pain Relevance 0.54

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