INT9853

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Context Info
Confidence 0.54
First Reported 1990
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.74
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt2b)
Anatomy Link Frequency
livers 1
Ugt2b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 40 100.00 Very High Very High Very High
Morphine 13 100.00 Very High Very High Very High
cINOD 3 84.96 Quite High
depression 1 50.00 Quite Low
Analgesic 1 32.04 Quite Low
Disease Link Frequency Relevance Heat
Jaundice 4 99.40 Very High Very High Very High
Toxicity 5 98.64 Very High Very High Very High
Hypoxia 11 98.24 Very High Very High Very High
Sprains And Strains 2 86.88 High High
Syndrome 5 76.88 Quite High
Body Weight 1 75.88 Quite High
INFLAMMATION 1 56.00 Quite High
Depression 1 50.00 Quite Low
Nephrotoxicity 2 45.32 Quite Low
Hepatotoxicity 1 40.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Flunitrazepam exerted a potent competitive inhibition of rat hepatic morphine UDP-glucuronosyltransferase (UDPGT) activity (Ki = 130 microM).
Negative_regulation (inhibition) of UDP-glucuronosyltransferase associated with morphine
1) Confidence 0.54 Published 1990 Journal Mol. Pharmacol. Section Abstract Doc Link 2119476 Disease Relevance 0 Pain Relevance 0.41
Thus, a deficiency in bilirubin UDP-glucuronosyltransferase, evidenced by jaundice, can be paralleled by a deficiency in glucuronidation of other compounds.
Negative_regulation (deficiency) of UDP-glucuronosyltransferase associated with jaundice
2) Confidence 0.49 Published 1992 Journal Gastroenterology Section Abstract Doc Link 1732127 Disease Relevance 0.39 Pain Relevance 0.72
By contrast to clofibrate, administration of pirprofen to rats decreased bilirubin UDP-glucuronosyltransferase in a time-dependent fashion with a maximal decrease of 59% after 5 days.
Negative_regulation (decreased) of UDP-glucuronosyltransferase
3) Confidence 0.49 Published 1990 Journal Drug Metab. Dispos. Section Abstract Doc Link 1981722 Disease Relevance 0.13 Pain Relevance 0.20
Biotransformation and toxicity of acetaminophen in congenic RHA rats with or without a hereditary deficiency in bilirubin UDP-glucuronosyltransferase.
Negative_regulation (deficiency) of bilirubin UDP-glucuronosyltransferase associated with toxicity and paracetamol
4) Confidence 0.42 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 1440617 Disease Relevance 0.43 Pain Relevance 0.66
Similar decreases in microsomal UDP-glucuronosyltransferase and cytosolic sulfotransferase activities were found in livers of animals exposed to chronic hypoxia.
Negative_regulation (decreases) of microsomal UDP-glucuronosyltransferase in livers associated with hypoxia
5) Confidence 0.33 Published 1991 Journal Biochem. Pharmacol. Section Abstract Doc Link 1872890 Disease Relevance 0.78 Pain Relevance 0.19
Cytochrome P450 concentration and oxidative demethylase activity toward p-nitroanisole were decreased in parallel, 47 and 53%, respectively, and UDP-glucuronosyltransferase activity with p-nitrophenol and acetaminophen as the acceptor aglycones was decreased 44 and 25%, respectively in the animals receiving TPN.
Negative_regulation (decreased) of UDP-glucuronosyltransferase associated with paracetamol
6) Confidence 0.31 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8632327 Disease Relevance 0 Pain Relevance 0.63
Parenteral nutrition decreased microsomal cytochrome P450 concentration (47%), p-nitroanisole demethylase activity (68%) and p-nitrophenol UDP-glucuronosyltransferase activity (58%).
Negative_regulation (decreased) of UDP-glucuronosyltransferase
7) Confidence 0.28 Published 1995 Journal JPEN J Parenter Enteral Nutr Section Body Doc Link 8523630 Disease Relevance 0 Pain Relevance 0

General Comments

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