INT9854

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Context Info
Confidence 0.78
First Reported 1986
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 6.09
Pain Relevance 3.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GGT1) plasma membrane (GGT1) transferase activity, transferring acyl groups (GGT1)
cellular amino acid metabolic process (GGT1)
Anatomy Link Frequency
liver 2
blood 1
brush 1
T-cell 1
urine 1
GGT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 30 99.52 Very High Very High Very High
Analgesic 3 99.52 Very High Very High Very High
cINOD 6 95.56 Very High Very High Very High
Chronic pancreatitis 6 93.48 High High
anesthesia 3 92.56 High High
Bile 39 90.52 High High
Rheumatism 1 90.36 High High
Angina 1 88.84 High High
alcohol 2 71.92 Quite High
Inflammation 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 2 99.82 Very High Very High Very High
Toxicity 22 99.30 Very High Very High Very High
Body Weight 1 97.04 Very High Very High Very High
Balkan Nephropathy 12 96.84 Very High Very High Very High
Renal Disease 17 96.52 Very High Very High Very High
Pancreatic Cancer 6 94.56 High High
Hypertension 5 94.52 High High
Obesity 4 94.24 High High
Pancreatitis 23 93.48 High High
Prehypertension 6 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Multiple regression analyses (dependent on amylase or IRT urinary outputs, circulating levels of the two enzymes, creatinine clearance and the excretion of GGT, AGL and RNase predictor variables) showed significant correlations.
Localization (excretion) of GGT associated with disorders of creatine metabolism
1) Confidence 0.78 Published 1990 Journal Clin Physiol Biochem Section Abstract Doc Link 1691065 Disease Relevance 0.88 Pain Relevance 0.36
Increased excretion of LDH and GGT indicated a similar moderate damage of the tubular epithelia after phenacetin and paracetamol.
Localization (excretion) of GGT associated with paracetamol
2) Confidence 0.78 Published 1986 Journal Clin. Chim. Acta Section Abstract Doc Link 2877759 Disease Relevance 0.17 Pain Relevance 0.43
Biochemical analysis showed normal range of ALT, AST, CBC, and GGT (Table 2).
Localization (range) of GGT
3) Confidence 0.73 Published 2010 Journal Journal of Toxicology Section Body Doc Link PMC2902021 Disease Relevance 0.55 Pain Relevance 0
Urinary excretion of alpha-glucosidase (AGL), gamma-glutamyltransferase (GGT) and ribonuclease (RNase), and serum amylase and immunoreactive trypsin (IRT) were determined in 38 control subjects, 48 patients with pancreatic cancer, 77 with chronic pancreatitis and 47 with extrapancreatic diseases in order to ascertain the presence of a renal tubular damage and to investigate its etiology.
Spec (determined) Localization (excretion) of GGT associated with pancreatic cancer, disease and chronic pancreatitis
4) Confidence 0.73 Published 1989 Journal Nephron Section Abstract Doc Link 2563574 Disease Relevance 0.43 Pain Relevance 0.17
Urinary excretion of three specific renal tubular enzymes--AAP: alanine-amino-peptidase, GGT: gamma-glutamyl-transpeptidase, and beta-NAG: beta-N-acetyl-glucosaminidase, were determined in 8-h overnight urine samples, as well as GFR creatinine clearance/1.73 m2, urinary volume/8 h, specific gravity of the urine, proteinuria and glucosuria.
Spec (determined) Localization (excretion) of GGT in urine associated with disorders of creatine metabolism and proteinuria
5) Confidence 0.73 Published 1993 Journal Ren Fail Section Abstract Doc Link 8095099 Disease Relevance 0.44 Pain Relevance 0.51
After acetaminophen administration urinary excretion of APN, dipeptidylpeptidase IV (DPP IV), gamma-glutamyltranspeptidase (GGT) and N-acetyl-beta-D-glucosaminidase (NAGA) did not increase significantly in any group studied.
Localization (excretion) of GGT associated with paracetamol
6) Confidence 0.73 Published 1999 Journal Ren Fail Section Abstract Doc Link 10516997 Disease Relevance 0.98 Pain Relevance 0.80
-glutamyl transpeptidase), measurement of serum amylase, lipase and coagulation profiles.
Localization (measurement) of glutamyl transpeptidase
7) Confidence 0.73 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687820 Disease Relevance 0 Pain Relevance 0.16
METHODS: We prospectively evaluated the levels of the serum concentration of liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP), and total bilirubin (TBil), in 42 morbidly obese and 40 non obese patients who were scheduled for elective abdominal surgery under sevoflurane anesthesia at the Jordan University Hospital, Amman, Jordan.
Localization (aspartate aminotransferase) of GGT in liver
8) Confidence 0.73 Published 2009 Journal Middle East J Anesthesiol Section Body Doc Link 19583067 Disease Relevance 0.19 Pain Relevance 0
Multiple regression analysis using SBP and DBP as objective variables, adjusted for risk factors as explanatory variables, showed that log GGT was significantly and independently associated with elevated SBP (beta = 0.109, P = 0.006) and DBP (beta = 0.238, P < 0.001).
Localization (log) of GGT
9) Confidence 0.73 Published 2008 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 18987455 Disease Relevance 1.20 Pain Relevance 0.12
METHODS: Using size-exclusion chromatography, sodium dodecyl sulfate/polyacrylamide gel electrophoresis, and a spectrophotometric enzyme assay, we identified the secreted gamma-glutamyl transpeptidase of H pylori (HPGGT) as the factor responsible for inhibition of T-cell proliferation.
Localization (secreted) of GGT in T-cell
10) Confidence 0.68 Published 2007 Journal Gastroenterology Section Body Doc Link 17484877 Disease Relevance 0 Pain Relevance 0
This study has shown that urinary excretion of APN, DPP IV, NAGA and GGT, as markers of kidney brush border and lysosomal damage, did not change after 2 g of acetaminophen taken orally. beta 2-microglobulin was a marker of acute acetaminophen nephrotoxicity in kidney disease patients and in clinically healthy adults from nephropathic families.
Localization (excretion) of GGT in brush associated with nephrotoxicity, paracetamol and renal disease
11) Confidence 0.68 Published 1999 Journal Ren Fail Section Abstract Doc Link 10516997 Disease Relevance 0.87 Pain Relevance 0.77
Our objectives were to characterize the acute toxicity of DAPM in liver, particularly on secretion of biliary constituents and on biliary epithelial cell gamma-glutamyl transpeptidase (GGT) activity.
Localization (secretion) of GGT in liver associated with toxicity
12) Confidence 0.68 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1440618 Disease Relevance 0.31 Pain Relevance 0.24
The effects of age, nature (single or multiple) and stated size of overdose, hepatic enzyme induction (gamma-glutamyl transpeptidase, GGT), degree of liver injury (aspartate aminotransferase, prothrombin time), blood pressure and renal injury were assessed.
Localization (degree) of GGT in blood
13) Confidence 0.32 Published 2009 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 18958458 Disease Relevance 0.08 Pain Relevance 0

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