INT98554

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 20
Total Number 23
Disease Relevance 21.32
Pain Relevance 2.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp8) peptidase activity (Casp8) mitochondrion (Casp8)
nucleus (Casp8) protein complex (Casp8) cytoplasm (Casp8)
Anatomy Link Frequency
T cells 4
plasma 1
liver 1
erythroblasts 1
MDA-MB-231 1
Casp8 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 10 99.52 Very High Very High Very High
Paracetamol 9 98.08 Very High Very High Very High
cytokine 94 95.68 Very High Very High Very High
fortral 12 91.48 High High
agonist 9 90.88 High High
withdrawal 7 90.56 High High
COX-2 inhibitor 20 87.48 High High
opioid receptor 4 87.20 High High
antagonist 7 84.80 Quite High
cva 62 84.08 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1002 100.00 Very High Very High Very High
Death 220 100.00 Very High Very High Very High
Medulloblastoma 1 99.84 Very High Very High Very High
Infection 209 99.60 Very High Very High Very High
Diabetes Mellitus 154 99.36 Very High Very High Very High
Hemorrhagic Shock 102 99.28 Very High Very High Very High
Melanoma 189 98.72 Very High Very High Very High
Retinoblastoma 2 97.20 Very High Very High Very High
Carcinoma 114 96.24 Very High Very High Very High
Stress 14 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with darbufelone also induced apoptosis by activating caspase-3 and caspase-8.
Positive_regulation (activating) of caspase-8
1) Confidence 0.67 Published 2010 Journal Cancer Chemother. Pharmacol. Section Body Doc Link 20352217 Disease Relevance 0.16 Pain Relevance 0
Caspase-3 and caspase-8 activation could not be detected.
Positive_regulation (activation) of caspase-8
2) Confidence 0.34 Published 2007 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 17207453 Disease Relevance 0.43 Pain Relevance 0.65
The question was raised as to why caspase-8 activity increased.
Positive_regulation (increased) of caspase-8
3) Confidence 0.28 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.95 Pain Relevance 0
Significantly elevated activities of caspase-3, caspase-8 and caspase-9 were observed in BJMC3879luc2 cells treated with raloxifene for 24 h (Figure 2B) and 48 h (data not shown), as compared to the respective controls.
Positive_regulation (activities) of caspase-8
4) Confidence 0.20 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.45 Pain Relevance 0
Caspase-8 participates in ERK activation, and this regulation is attributed to the Death Effector Domains (DED) of caspase-8 [35].
Positive_regulation (activation) of Caspase-8 associated with death
5) Confidence 0.19 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.96 Pain Relevance 0
Up-regulation of FLIP, caspase-8 inhibitor, enhanced NF-?
Positive_regulation (regulation) of caspase-8
6) Confidence 0.18 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.90 Pain Relevance 0.09
Thereby, HS animals demonstrated significantly increased caspase-3/7, caspase-8, and caspase-9 activities at t = 0 hours and t = 72 hours in splenic tissue when compared with the appropriate sham-operated or control animals (Figure 2c).
Positive_regulation (increased) of caspase-8 associated with hemorrhagic shock
7) Confidence 0.17 Published 2008 Journal Crit Care Section Body Doc Link PMC2374615 Disease Relevance 1.14 Pain Relevance 0.12
Due to the observed activation of caspase-8, an involvement of receptor-mediated pathways in HS-induced apoptotic changes cannot be excluded.
Positive_regulation (activation) of caspase-8 associated with apoptosis and hemorrhagic shock
8) Confidence 0.17 Published 2008 Journal Crit Care Section Body Doc Link PMC2374615 Disease Relevance 1.68 Pain Relevance 0.10
We investigated the activation of several central apoptosis regulators, such as caspase-8 and its substrate Bid, caspase-9 and caspase-3, along with crucial biochemical parameters such as mitochondrial integrity and release of cytochrome-c, Smac/Diabolo and AIF into the cytoplasm.
Spec (investigated) Positive_regulation (activation) of caspase-8 associated with apoptosis
9) Confidence 0.11 Published 2006 Journal J Carcinog Section Body Doc Link PMC1665446 Disease Relevance 1.10 Pain Relevance 0
The inhibition of T-cell function with low-dose morphine was associated with an increase in caspase-3- and caspase-8-mediated apoptosis.
Positive_regulation (increase) of caspase-8-mediated in T-cell associated with apoptosis and morphine
10) Confidence 0.08 Published 2001 Journal J. Leukoc. Biol. Section Abstract Doc Link 11590188 Disease Relevance 0.34 Pain Relevance 0.96
to upregulate caspase-8 in medulloblastoma cells lacking caspase-8, and restore TRAIL-mediated cytotoxicity.
Positive_regulation (upregulate) of caspase-8 associated with medulloblastoma
11) Confidence 0.07 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.11 Pain Relevance 0.14
Rimcazole did not upregulate TRAIL-R1 or TRAIL-R2 expression (data not shown), but augmented the activation of initiator caspase-8 and initiator caspase-9 upon anti-MCSP:TRAIL treatment (Additional file 3, Figure S2A and B, respectively).
Positive_regulation (activation) of caspase-8
12) Confidence 0.07 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.62 Pain Relevance 0.18
Moreover, CD4+ and CD8+ T lymphocytes are affected by Fas-induced apoptosis, since activated T lymphocytes increase Fas, FasL expression, and caspase-8 activation in acute infection [51],[68].
Positive_regulation (activation) of caspase-8 in T lymphocytes associated with apoptosis and infection
13) Confidence 0.06 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 0.88 Pain Relevance 0.08
Activation of caspase 8, 9 and 3 and mitochondrial potential disruption, were observed in erythroblasts, implicating both extrinsic and intrinsic pathways in the execution of apoptosis.
Positive_regulation (Activation) of caspase 8 in erythroblasts associated with apoptosis
14) Confidence 0.06 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.08 Pain Relevance 0.04
Indeed, treatment of melanoma cells with anti-MCSP:TRAIL was characterized by time-dependent activation of initiator caspase-8 (Additional file 1, Figure S1B) as well as effector caspases 3 and 7 (Additional file 1, Figure S1C).
Positive_regulation (activation) of caspase-8 associated with melanoma
15) Confidence 0.05 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.95 Pain Relevance 0
Thus, rimcazole appears to synergize the activity of anti-MCSP:TRAIL by promoting caspase-8 activation.
Positive_regulation (activation) of caspase-8
16) Confidence 0.05 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.64 Pain Relevance 0.15
In addition, cholesterol-enriched micro-domains, so called lipid rafts, are important signal transduction platforms [24], which have been related to apoptosis [25] and changes in plasma cholesterol levels have been associated with Fas-FADD complex formation and caspase-8 activation [26], [27].
Positive_regulation (activation) of caspase-8 in plasma associated with apoptosis
17) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671171 Disease Relevance 0.57 Pain Relevance 0
In the presence of an antigen, IL-2 prompts T cells to die by AICD, through activation of death receptor molecules and caspase-8 [46]–[48].
Positive_regulation (activation) of caspase-8 in T cells associated with death
18) Confidence 0.04 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 1.58 Pain Relevance 0.25
The levels of Fas expression and caspase 8 activities are the same in infected and uninfected liver cells of mice, but hydroxyl radicals are increased in infected mice [36].
Positive_regulation (increased) of caspase 8 in liver
19) Confidence 0.04 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.43 Pain Relevance 0.04
Immunoblot analysis indicated increased active, cleaved caspase-9 levels solely in non-adherent CXCL12-expressing cells compared to active caspase-8, suggesting an intrinsic apoptotic mechanism driving anoikis of those cells (Figure 4A).
Positive_regulation (increased) of caspase-8 associated with apoptosis
20) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.48 Pain Relevance 0

General Comments

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