INT98592

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 5.23
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ILK) cytosol (ILK) plasma membrane (ILK)
protein complex (ILK) cytoplasm (ILK) signal transducer activity (ILK)
Anatomy Link Frequency
capsules 1
ILK (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 14 90.68 High High
aspirin 12 89.76 High High
antagonist 3 68.88 Quite High
diclofenac 10 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
COX-2 inhibitor 5 5.00 Very Low Very Low Very Low
Nicotine 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polyps 8 99.84 Very High Very High Very High
Familial Adenomatous Polyposis 16 99.36 Very High Very High Very High
Capsule Opacification 225 99.02 Very High Very High Very High
Congenital Anomalies 4 96.52 Very High Very High Very High
Disease 11 94.44 High High
INFLAMMATION 10 90.12 High High
Adhesions 16 86.16 High High
Cancer 50 81.28 Quite High
Cataract 95 78.24 Quite High
Corneal Edema 5 63.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, overexpression of the integrin-linked kinase (ILK) has been shown to modulate beta-catenin subcellular localization and function.
Gene_expression (overexpression) of integrin-linked kinase
1) Confidence 0.78 Published 2001 Journal Oncogene Section Abstract Doc Link 11593435 Disease Relevance 0.61 Pain Relevance 0.03
Here, we report the increased biochemical activity and expression of ILK protein in polyps from FAP patients.
Gene_expression (expression) of ILK protein associated with familial adenomatous polyposis and polyps
2) Confidence 0.78 Published 2001 Journal Oncogene Section Abstract Doc Link 11593435 Disease Relevance 0.69 Pain Relevance 0.17
Intriguingly, overexpression of the integrin-linked kinase (ILK) has been shown to modulate beta-catenin subcellular localization and function.
Gene_expression (overexpression) of ILK
3) Confidence 0.78 Published 2001 Journal Oncogene Section Abstract Doc Link 11593435 Disease Relevance 0.61 Pain Relevance 0.03
In conclusion, ILK protein hyperexpression appears to be an early event in colonic polyposis.
Gene_expression (hyperexpression) of ILK protein
4) Confidence 0.68 Published 2001 Journal Oncogene Section Abstract Doc Link 11593435 Disease Relevance 0.54 Pain Relevance 0.27
In support of this, LEC present in our ex vivo PCO model were undergoing EMT and were positive for ILK expression.
Gene_expression (expression) of ILK associated with capsule opacification
5) Confidence 0.46 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.55 Pain Relevance 0
In this study, we did not see any changes in expression of ILK in capsules that were treated with AR-12.
Gene_expression (expression) of ILK in capsules
6) Confidence 0.40 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.60 Pain Relevance 0
Immunohistochemical staining was performed as previously described [38] using antibodies against TERT (1:350; Calbiochem, San Diego CA), pAkt (1:350; Santa Cruz, Santa Cruz, CA), cleaved caspase-3 (1:20; Oncogene, San Diego CA), ILK (1:200; Stressgen, San Diego CA), ?
Gene_expression (using) of ILK
7) Confidence 0.40 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0 Pain Relevance 0
These findings support the hypothesis that ILK is an upstream mediator of Akt activation and not directly affected by inhibition of pAkt.
Gene_expression (activation) of ILK
8) Confidence 0.40 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.61 Pain Relevance 0
Transfection of LEC with ILK-expressing constructs induces a morphologic change that resembles EMT [4].
Gene_expression (Transfection) of ILK-expressing
9) Confidence 0.40 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.60 Pain Relevance 0
ligands) inhibit integrin-linked kinase (ILK) expression through PPAR?
Gene_expression (expression) of ILK
10) Confidence 0.31 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 0.42 Pain Relevance 0.03

General Comments

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