INT98594

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.74
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ILK) cytosol (ILK) plasma membrane (ILK)
protein complex (ILK) cytoplasm (ILK) signal transducer activity (ILK)
ILK (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 96.16 Very High Very High Very High
aspirin 6 87.24 High High
Somatostatin 4 70.80 Quite High
Inflammation 2 47.92 Quite Low
cytokine 2 37.20 Quite Low
metalloproteinase 2 26.80 Quite Low
withdrawal 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 4 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Familial Adenomatous Polyposis 8 98.68 Very High Very High Very High
Polyps 4 98.32 Very High Very High Very High
INFLAMMATION 4 95.60 Very High Very High Very High
Congenital Anomalies 2 82.68 Quite High
Shock 4 77.88 Quite High
Aging 57 72.92 Quite High
Apoptosis 8 43.04 Quite Low
Adhesions 1 34.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, dramatic increases in ILK immunoreactivity were observed in all abnormal crypts from sporadic polyps, when compared with the normal appearing crypts within the same resected specimens.
Positive_regulation (increases) of ILK associated with polyps
1) Confidence 0.70 Published 2001 Journal Oncogene Section Abstract Doc Link 11593435 Disease Relevance 0.69 Pain Relevance 0.18
These include inhibition of, both the biochemical activation of ILK, inhibition of serine 9 GSK3beta phosphorylation and the enhancement of TCF-4 transcriptional activity.
Positive_regulation (activation) of ILK
2) Confidence 0.70 Published 2001 Journal Oncogene Section Abstract Doc Link 11593435 Disease Relevance 0.58 Pain Relevance 0.27
Several significantly downregulated genes were also found to be present in the senescent cells; these included alpha-2-glycoprotein 1, tumor necrosis factor superfamily, member 13b, integrin-linked kinase-2, the G1 to S phase transition 2 gene, cell division cycle 2-like 6 (CDK8-like) gene, and Ras homolog gene family member H.


Positive_regulation (included) of integrin-linked kinase-2 associated with necrosis and cancer
3) Confidence 0.20 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.47 Pain Relevance 0.04

General Comments

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