INT98595

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.84
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ILK) cytosol (ILK) plasma membrane (ILK)
protein complex (ILK) cytoplasm (ILK) signal transducer activity (ILK)
ILK (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 16 100.00 Very High Very High Very High
cINOD 14 99.96 Very High Very High Very High
adenocard 1 38.92 Quite Low
agonist 12 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 14 99.68 Very High Very High Very High
Familial Adenomatous Polyposis 22 98.16 Very High Very High Very High
Polyps 12 97.92 Very High Very High Very High
Congenital Anomalies 5 93.72 High High
Apoptosis 47 93.44 High High
Cancer 23 80.56 Quite High
Colon Cancer 17 75.76 Quite High
Liver Cancer 5 67.28 Quite High
Hepatocellular Cancer 8 35.00 Quite Low
Breast Cancer 3 26.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis.
Regulation (Dysregulation) of integrin-linked kinase associated with aspirin
1) Confidence 0.62 Published 2001 Journal Oncogene Section Title Doc Link 11593435 Disease Relevance 0.66 Pain Relevance 0.20
Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis.
Regulation (Dysregulation) of ILK associated with aspirin
2) Confidence 0.62 Published 2001 Journal Oncogene Section Title Doc Link 11593435 Disease Relevance 0.66 Pain Relevance 0.20
As sulindac and aspirin are the two most important therapeutic/chemopreventative agents demonstrated in colorectal carcinogenesis, in both humans and animals, further investigation revealed that these non-steroidal anti-inflammatory drugs (NSAIDs) target ILK and ILK-mediated events in vivo.
Regulation (target) of ILK associated with aspirin, inflammation and cinod
3) Confidence 0.62 Published 2001 Journal Oncogene Section Abstract Doc Link 11593435 Disease Relevance 0.61 Pain Relevance 0.28
Furthermore, dramatic increases in ILK immunoreactivity were observed in all abnormal crypts from sporadic polyps, when compared with the normal appearing crypts within the same resected specimens.
Regulation (immunoreactivity) of ILK associated with polyps
4) Confidence 0.27 Published 2001 Journal Oncogene Section Abstract Doc Link 11593435 Disease Relevance 0.69 Pain Relevance 0.18
As sulindac and aspirin are the two most important therapeutic/chemopreventative agents demonstrated in colorectal carcinogenesis, in both humans and animals, further investigation revealed that these non-steroidal anti-inflammatory drugs (NSAIDs) target ILK and ILK-mediated events in vivo.
Regulation (target) of ILK-mediated associated with aspirin, inflammation and cinod
5) Confidence 0.27 Published 2001 Journal Oncogene Section Abstract Doc Link 11593435 Disease Relevance 0.61 Pain Relevance 0.28
Both 3-phosphoinositide-dependent kinase-1 and integrin-linked kinase are target genes of PPAR?.
Regulation (target) of integrin-linked kinase
6) Confidence 0.04 Published 2003 Journal Comp Hepatol Section Body Doc Link PMC151270 Disease Relevance 0.59 Pain Relevance 0

General Comments

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