INT98597

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 3.08
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ILK) cytosol (ILK) plasma membrane (ILK)
protein complex (ILK) cytoplasm (ILK) signal transducer activity (ILK)
ILK (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 9 80.48 Quite High
cINOD 8 64.56 Quite High
diclofenac 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polyps 6 99.84 Very High Very High Very High
Familial Adenomatous Polyposis 12 99.36 Very High Very High Very High
Capsule Opacification 90 99.28 Very High Very High Very High
Congenital Anomalies 3 96.52 Very High Very High Very High
Disease 4 94.44 High High
Cataract 38 78.24 Quite High
INFLAMMATION 3 64.16 Quite High
Apoptosis 16 51.84 Quite High
Corneal Edema 2 47.44 Quite Low
Adhesions 6 43.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, overexpression of the integrin-linked kinase (ILK) has been shown to modulate beta-catenin subcellular localization and function.
Positive_regulation (overexpression) of Gene_expression (overexpression) of integrin-linked kinase
1) Confidence 0.70 Published 2001 Journal Oncogene Section Abstract Doc Link 11593435 Disease Relevance 0.61 Pain Relevance 0.03
Here, we report the increased biochemical activity and expression of ILK protein in polyps from FAP patients.
Positive_regulation (increased) of Gene_expression (expression) of ILK protein associated with familial adenomatous polyposis and polyps
2) Confidence 0.50 Published 2001 Journal Oncogene Section Abstract Doc Link 11593435 Disease Relevance 0.70 Pain Relevance 0.17
Intriguingly, overexpression of the integrin-linked kinase (ILK) has been shown to modulate beta-catenin subcellular localization and function.
Positive_regulation (overexpression) of Gene_expression (overexpression) of ILK
3) Confidence 0.50 Published 2001 Journal Oncogene Section Abstract Doc Link 11593435 Disease Relevance 0.61 Pain Relevance 0.03
Transfection of LEC with ILK-expressing constructs induces a morphologic change that resembles EMT [4].
Positive_regulation (Transfection) of Gene_expression (Transfection) of ILK-expressing
4) Confidence 0.30 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.60 Pain Relevance 0
In support of this, LEC present in our ex vivo PCO model were undergoing EMT and were positive for ILK expression.
Positive_regulation (positive) of Gene_expression (expression) of ILK associated with capsule opacification
5) Confidence 0.28 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.55 Pain Relevance 0

General Comments

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