INT98607

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2009
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 6.95
Pain Relevance 2.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
brain 2
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 161 100.00 Very High Very High Very High
cytokine 97 100.00 Very High Very High Very High
addiction 1 100.00 Very High Very High Very High
Osteoarthritis 3 99.28 Very High Very High Very High
cINOD 1 98.12 Very High Very High Very High
Pain 11 96.96 Very High Very High Very High
Inflammatory mediators 22 96.80 Very High Very High Very High
rheumatoid arthritis 66 89.68 High High
Arthritis 81 85.52 High High
Crohn's disease 1 83.64 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 197 100.00 Very High Very High Very High
Disease 97 100.00 Very High Very High Very High
Osteoarthritis 3 99.28 Very High Very High Very High
Asthma 31 98.90 Very High Very High Very High
Targeted Disruption 7 97.92 Very High Very High Very High
Blister 23 97.84 Very High Very High Very High
Closed Head Injuries 22 97.56 Very High Very High Very High
Pain 9 96.96 Very High Very High Very High
Insulin Resistance 19 92.88 High High
Rheumatoid Arthritis 66 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to determine the contribution of pro-inflammatory cytokines to the disease activity, both IL-6 and TNF-?
Regulation (determine) of Regulation (contribution) of TNF associated with inflammation, disease and cytokine
1) Confidence 0.44 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693561 Disease Relevance 0.70 Pain Relevance 0.24
in asthma has been suggested by various animal studies, showing alteration of the contractile properties of the airway smooth muscle18 and regulation of AHR and neutrophilia.19 Furthermore, TNF-?
Regulation (alteration) of Regulation (regulation) of TNF associated with asthma
2) Confidence 0.44 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 1.34 Pain Relevance 0.40
Quercetin inhibits inflammatory reactions by regulating the generation of inflammatory cytokines such as IL-6, TNF-?
Regulation (regulating) of Regulation (generation) of TNF associated with inflammation and cytokine
3) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374451 Disease Relevance 1.16 Pain Relevance 0.55
The experimental part of the study was set-up on two different protocols with the aim to assess the TNF-dependent regulation of IL-18 in the murine brain:

(1) The first part of the experimental study was designed to investigate a potential role of TNF-dependent regulation of intracranial IL-18 expression in a standardized model of CHI, using mice double-deficient in genes for TNF and lymphotoxin-?

Spec (investigate) Regulation (role) of Spec (investigate) Regulation (regulation) of TNF-dependent in brain associated with closed head injuries
4) Confidence 0.29 Published 2004 Journal J Neuroinflammation Section Body Doc Link PMC506787 Disease Relevance 0.46 Pain Relevance 0.03
production shows a wide variation, with high- and low-producer phenotypes present in humans [2] but with a strong concordance in monozygotic twins [3], pointing to the influence of genetic variation on the regulation of TNF-?
Regulation (influence) of Regulation (regulation) of TNF
5) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906815 Disease Relevance 0.52 Pain Relevance 0.13
indicating that circulating IL-6 is involved in the regulation of TNF-?
Regulation (involved) of Regulation (regulation) of TNF
6) Confidence 0.23 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2615833 Disease Relevance 0.41 Pain Relevance 0.16
[Effect of naproxen on serum concentrations of IL-I, IL-6, and TNF in patients with osteoarthritis].
Regulation ([Effect) of Regulation (concentrations) of TNF associated with osteoarthritis
7) Confidence 0.15 Published 2001 Journal Rev Alerg Mex Section Title Doc Link 11593916 Disease Relevance 0.29 Pain Relevance 0.33
However, in our studies, anti-TNF mAb treatment reduced serum IL-6 by a similar magnitude as CP-690550 but did not demonstrate the same degree of efficacy, which suggests the JAK3 inhibitor, affected other inflammatory mediators important for expression of disease in this model.
Neg (not) Regulation (demonstrate) of Regulation (treatment) of anti-TNF associated with inflammatory mediators and disease
8) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374467 Disease Relevance 1.02 Pain Relevance 0.46
3.2. regulation of PPAR and Zn dependence for immune regulation of TNF [355]
Regulation (regulation) of Regulation (regulation) of TNF associated with addiction
9) Confidence 0.05 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1820789 Disease Relevance 1.06 Pain Relevance 0.27

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