INT98609

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 6.21
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PYGM) small molecule metabolic process (PYGM) transferase activity, transferring glycosyl groups (PYGM)
carbohydrate metabolic process (PYGM) cytoplasm (PYGM)
Anatomy Link Frequency
muscle 7
muscle fibers 1
PYGM (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 5 94.08 High High
Infliximab 60 90.44 High High
corticosteroid 18 86.48 High High
methotrexate 16 84.88 Quite High
Pain 19 78.32 Quite High
withdrawal 3 72.56 Quite High
agonist 2 68.08 Quite High
dopamine receptor 1 65.52 Quite High
Central nervous system 1 64.80 Quite High
anesthesia 7 42.00 Quite Low
Disease Link Frequency Relevance Heat
Disease 71 99.96 Very High Very High Very High
Glycogen Storage Disease 11 99.78 Very High Very High Very High
Rhabdomyolysis 105 98.96 Very High Very High Very High
Muscle Disease 28 98.84 Very High Very High Very High
Glycogen Storage Disease Type V 1 98.74 Very High Very High Very High
Repression 6 98.62 Very High Very High Very High
Pulmonary Sarcoidosis 11 97.92 Very High Very High Very High
Necrosis 9 97.36 Very High Very High Very High
Coronary Heart Disease 17 95.40 Very High Very High Very High
Sarcoidosis 72 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[McArdle disease: report of four brothers with myophosphorylase deficiency].
Negative_regulation (deficiency) of myophosphorylase associated with disease
1) Confidence 0.43 Published 2001 Journal An Med Interna Section Title Doc Link 11594178 Disease Relevance 0.83 Pain Relevance 0.08
Myophosphorylase deficiency, or McArdle disease, is an uncommon entity.
Negative_regulation (deficiency) of Myophosphorylase associated with disease
2) Confidence 0.43 Published 2001 Journal An Med Interna Section Abstract Doc Link 11594178 Disease Relevance 0.61 Pain Relevance 0.06
Glycogen Storage Disease Type V (McArdle Disease; Deficiency of Muscle Phosphorylase)

PathophysiologyMyophosphorylase activity is deficient in McArdle disease (OMIM 232600); the disorder is inherited as an autosomal recessive trait.

Negative_regulation (deficient) of PathophysiologyMyophosphorylase in Muscle associated with glycogen storage disease type v and disease
3) Confidence 0.15 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2877206 Disease Relevance 0.61 Pain Relevance 0
Fouchier and colleagues (2004) reported a patient with persistent, refractory symptomatic pulmonary sarcoidosis, complicated by a congenital muscular disease: McArdle’s disease (a glycogen storage disease caused by myophosphorylase deficiency).
Negative_regulation (deficiency) of myophosphorylase associated with pulmonary sarcoidosis, glycogen storage disease, muscle disease and disease
4) Confidence 0.11 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643111 Disease Relevance 1.51 Pain Relevance 0.24
McArdle's disease (myophosphorylase deficiency) is an autosomal recessive condition in which there is selective necrosis of type 2 muscle fibers [51].
Negative_regulation (deficiency) of myophosphorylase in muscle fibers associated with necrosis and disease
5) Confidence 0.03 Published 2005 Journal Crit Care Section Body Doc Link PMC1175909 Disease Relevance 2.22 Pain Relevance 0.22
Of notice is also that the same degree of repression of PDHa activity and PDH dephosphorylation changes was evident when muscle glycogen was lowered to 268 mmol/kg dry wt or plasma FFA was elevated to 714 ?
Negative_regulation (lowered) of muscle glycogen in muscle associated with repression
6) Confidence 0.03 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.10 Pain Relevance 0
In addition, we have recently shown that PDK4 protein content is increased 6 h after a prolonged exercise session, and although this change was associated with reduced muscle glycogen, a decline in muscle glycogen was not required to obtain an increase in PDK4 protein expression after prolonged exercise in that study (26).
Negative_regulation (decline) of muscle glycogen in muscle
7) Confidence 0.03 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
However, the observation that the highest exercise-induced PDHa activity and largest PDH dephosphorylation were present when the muscle glycogen level was only moderately reduced and when FFA remained close to baseline levels (193 ?
Negative_regulation (reduced) of muscle glycogen in muscle
8) Confidence 0.03 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.23 Pain Relevance 0
To reduce muscle glycogen in one leg, the subjects performed a one-legged cycling exercise protocol, consisting of 20 min continuous cycling (10 min 65% Wattmax and 10 min 55% Wattmax) followed by intermittent one-legged cycling as previously described (15).
Negative_regulation (reduce) of muscle glycogen in muscle
9) Confidence 0.02 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0.09 Pain Relevance 0
The current finding that PDK4 protein content was higher in the muscle with low glycogen than the control muscle both before and after exercise and in both trials indicates that reduced muscle glycogen levels could be an initiating signal to increase PDK4 expression.
Negative_regulation (reduced) of muscle glycogen in muscle
10) Confidence 0.02 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0
Similarly, manipulation of the muscle glycogen content in humans has indicated that lowering of muscle glycogen upregulates PDK4 at the transcriptional and mRNA level (15,16).
Negative_regulation (lowering) of muscle glycogen in muscle
11) Confidence 0.02 Published 2010 Journal Diabetes Section Body Doc Link PMC2797931 Disease Relevance 0 Pain Relevance 0

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