INT98613

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 7.86
Pain Relevance 4.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CSAD) small molecule metabolic process (CSAD) lyase activity (CSAD)
cellular nitrogen compound metabolic process (CSAD)
Anatomy Link Frequency
forearm 1
brain 1
primary visual cortex 1
CSAD (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 72 100.00 Very High Very High Very High
Migraine 393 99.62 Very High Very High Very High
Endep 7 95.48 Very High Very High Very High
headache 96 93.68 High High
excitatory amino acid 1 91.20 High High
imagery 39 90.72 High High
hyperexcitability 12 88.36 High High
antagonist 10 81.24 Quite High
Thalamus 1 72.60 Quite High
Pain 18 65.04 Quite High
Disease Link Frequency Relevance Heat
Depression 72 100.00 Very High Very High Very High
Epilepsy 82 99.80 Very High Very High Very High
Headache 427 99.62 Very High Very High Very High
Migraine Disorders 13 93.68 High High
Migraine Without Aura 81 92.68 High High
Migraine With Aura 66 92.32 High High
Cleidocranial Dysplasia 2 91.52 High High
Increased Venous Pressure Under Development 18 89.72 High High
Congenital Anomalies 29 84.24 Quite High
Brain Disease 4 75.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this context, the role of area V3A is particularly intriguing, since it has been suggested as the source of CSD during the aura phase.
Gene_expression (source) of CSD associated with epilepsy and depression
1) Confidence 0.53 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1609120 Disease Relevance 1.21 Pain Relevance 0.54
This paper will, based on the experience related to the detection of CSD in humans, discuss pitfalls and possible strategies for detection of CSD in man.
Gene_expression (detection) of CSD associated with depression
2) Confidence 0.53 Published 2001 Journal Cephalalgia Section Abstract Doc Link 11595007 Disease Relevance 1.03 Pain Relevance 0.61
Should CSD be of pivotal importance in migraine and aura symptoms reflect a CSD-like phenomenon in the human brain, there is no clear reason that only some migraine patients experience aura.
Gene_expression (reflect) of CSD in brain associated with epilepsy, depression and migraine
3) Confidence 0.46 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1609120 Disease Relevance 2.06 Pain Relevance 0.97
This method of anatomical registration is based on previous work in the primary visual cortex of monkeys employing a combination of CSD analysis, microlesions, and post mortem histology, which demonstrated that the initial current sink originates in layer 4C, possibly with its peak in layer 4C?
Gene_expression (analysis) of CSD in primary visual cortex
4) Confidence 0.23 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2928665 Disease Relevance 0 Pain Relevance 0
Interestingly, ET-1 has been shown to produce cortical spreading depression (CSD) in rats [13].
Gene_expression (produce) of CSD associated with depression
5) Confidence 0.15 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 1.37 Pain Relevance 0.89
CSD: cortical spreading depression; ET-1: endothelin-1; FBF: forearm blood flow; FMD: flow-mediated dilation; L-NMMA: NG-monomethyl-L-arginine; NO: nitric oxide; NOS: nitric oxide synthase; SBP: systolic blood pressure; SNP: sodium nitroprusside; t-PA: tissue plasminogen activator

Competing interests

Gene_expression (synthase) of CSD in forearm associated with depression
6) Confidence 0.13 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3017034 Disease Relevance 0.75 Pain Relevance 0.45
They suggested that CSD inhibition might be a common mode of action of drugs effective in migraine prevention, which is provocative and thought-provoking for several reasons (see Schoenen 2006 for discussion): (i) there is no clinical evidence that CSD occurs in migraine without aura; (ii) all compounds in Ayata et al’s study were administered in very high doses compared to those used in migraine treatment; (iii) and finally, no genetic mutation able to modify the CSD threshold has been identified in the common forms of migraine.
Gene_expression (inhibition) of CSD associated with depression and migraine
7) Confidence 0.05 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646639 Disease Relevance 1.38 Pain Relevance 1.30
Because such patterns of CSD and multiunit firing were never observed during transitions to active states, thalamic initiation of active states could be excluded.


Gene_expression (patterns) of CSD
8) Confidence 0.03 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2951844 Disease Relevance 0.06 Pain Relevance 0.04

General Comments

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