INT98621

Context Info Confidence 0.62 First Reported 2001 Last Reported 2011 Negated 5 Speculated 14 Reported most in Body Documents 121 Total Number 140 Disease Relevance 79.24 Pain Relevance 75.23

cytosol (Trpv1) transport (Trpv1) plasma membrane (Trpv1) transmembrane transport (Trpv1) lipid metabolic process (Trpv1)

Anatomy Link Frequency neurons 19 sensory neurons 5 body 3 nociceptors 3 nerve 3 Trpv1 (Mus musculus)

Pain Link Frequency Relevance Heat qutenza 2716 100.00 Pain 2221 100.00 Inflammation 1117 100.00 antagonist 729 100.00 nociceptor 546 100.00 opioid receptor 386 100.00 Analgesic 194 100.00 Sciatic nerve 94 100.00 Endocannabinoid 85 100.00 unmyelinated 66 100.00

Disease Link Frequency Relevance Heat Pain 2198 100.00 Nociception 858 100.00 Inflammatory Pain 221 100.00 Hypersensitivity 194 100.00 Targeted Disruption 648 99.96 Hyperalgesia 1350 99.92 Cancer Pain 19 99.86 Ganglion Cysts 2046 99.84 Diabetes Mellitus 1030 99.84 Depression 171 99.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

An emerging concept with important implications for drug development is that TRPV1 may be differentially regulated under physiological and pathological conditions.

Regulation (regulated) of TRPV1

1) Confidence 0.62 Published 2006 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 16773387 Disease Relevance 0 Pain Relevance 0.22

Activity of TRPV1 is modulated by actions of various kinases such as protein kinase A and C.

Regulation (modulated) of TRPV1

2) Confidence 0.62 Published 2005 Journal Curr. Pharm. Des. Section Abstract Doc Link 16101449 Disease Relevance 0.29 Pain Relevance 0.44

Cisplatin induced significant up-regulation of TRPV1 and TRPA1 mRNA (3-fold) in cultured DRG neurons at 6 h (Figure 2A and 2C).

Regulation (regulation) of TRPV1 in neurons associated with dorsal root ganglion

3) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.46 Pain Relevance 0.27

We also illustrate that up-regulation of TRPV1 and TRPA1 mRNA reflects increases in TRPV1 and TRPA1 responsiveness in the nociceptors that contribute to the molecular mechanisms of the thermal hyperalgesia and mechanical allodynia observed in cisplatin-treated mice.

Regulation (regulation) of TRPV1 in nociceptors associated with allodynia, thermal hyperalgesia and nociceptor

4) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.86 Pain Relevance 0.67

While our results illustrate that changes in the relative levels of TRPV1 and TRPA1 mRNA in vivo were similar to those observed in vitro (Figure 2), the increase in TRPM8 mRNA that was observed in oxaliplatin-treated mice was less than that seen in vitro.

Regulation (changes) of TRPV1

5) Confidence 0.61 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.78 Pain Relevance 0.61

Our objectives were to examine whether propofol modulates TRPV1 function in dorsal root ganglion neurons via activation of PKCepsilon.

Spec (whether) Regulation (modulates) of TRPV1 in neurons associated with ganglion cysts and root ganglion neuron

6) Confidence 0.61 Published 2010 Journal Anesthesiology Section Abstract Doc Link 20808213 Disease Relevance 0.36 Pain Relevance 0.22

In this study, we selected miogadial (MD), miogatrial (MT), and polygodial (PG) from the terpenoids with an alpha,beta-unsaturated 1,4-dialdehyde moiety and examined the effects of these 3 terpenoids on TRPA1 or TRPV1.

Spec (examined) Regulation (effects) of TRPV1

7) Confidence 0.61 Published 2009 Journal Life Sci. Section Abstract Doc Link 19409911 Disease Relevance 0.09 Pain Relevance 0.04

The reason that there has been no study describing the involvement of a PKC-dependent pathway in the regulation of TRPV1 following prostaglandin receptor activation is not clear.

Regulation (regulation) of TRPV1

8) Confidence 0.60 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.32 Pain Relevance 0.33

VR1 activity is regulated both directly and indirectly by endogenous factors.

Regulation (regulated) of VR1

9) Confidence 0.60 Published 2002 Journal Curr. Opin. Neurobiol. Section Abstract Doc Link 12139983 Disease Relevance 0.51 Pain Relevance 0.55

More importantly, we show that the shRNA and miRNA sequences targeting trpV1 have no effect on the expression levels of the closely related trpA1 gene or stat1, which is another gene involved in the INF response, when expressed in neurons in vivo.

Regulation (targeting) of trpV1 in neurons

10) Confidence 0.59 Published 2008 Journal Nucleic Acids Research Section Body Doc Link PMC2504301 Disease Relevance 0.27 Pain Relevance 0.10

Overall, the regulation of Trpv1 did not correlate significantly with any of the pain parameters considered.

Regulation (regulation) of Trpv1 associated with pain

11) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.09 Pain Relevance 0.43

Regardless, BH4-induced intracellular calcium increase in primary cultured DRG neurons is partly dependent on NOS [19], and essentially dependent on TRPV1 and TRPA1 (Fig. 5).

Regulation (dependent) of TRPV1 in neurons

12) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 0.59 Pain Relevance 0.33

The plasticity of A-fiber neurons is an important mechanism that causes hyperalgesia following inflammation, therefore, increased TDAG8 expression in A-fiber could be involved in mechanical and thermal hyperalgesia by regulating TRPV1 function.

Regulation (regulating) of TRPV1 in neurons associated with hyperalgesia, inflammation and thermal hyperalgesia

13) Confidence 0.56 Published 2009 Journal Mol Pain Section Body Doc Link PMC2716309 Disease Relevance 0.61 Pain Relevance 0.75

The functional regulation of TRPV1 and its role in pain sensitization.

Regulation (regulation) of TRPV1 associated with pain and qutenza

14) Confidence 0.54 Published 2008 Journal Neurochem. Res. Section Title Doc Link 18528757 Disease Relevance 0.74 Pain Relevance 1.20

Recently, advances have been made at the molecular and biochemical level to understand how phosphorylation by protein kinases regulates TRPV1 desensitization.

Regulation (regulates) of TRPV1

15) Confidence 0.52 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.07 Pain Relevance 0.56

The TRPV1 channel is known to be a critical molecular transducer of heat and is modulated by protons [19].

Regulation (modulated) of TRPV1

16) Confidence 0.51 Published 2006 Journal Mol Pain Section Body Doc Link PMC1660571 Disease Relevance 1.11 Pain Relevance 0.72

Therefore, we examined the effects of a selective TRPV1 antagonist, 5-iodoresiniferatoxin (I-RTX), on mouse body temperature.

Spec (examined) Regulation (effects) of TRPV1 in body associated with antagonist

17) Confidence 0.45 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15947039 Disease Relevance 0.07 Pain Relevance 0.40

TRPV1: a therapeutic target for novel analgesic drugs?

Regulation (target) of TRPV1 associated with analgesic

18) Confidence 0.45 Published 2006 Journal Trends Mol Med Section Title Doc Link 16996800 Disease Relevance 0.95 Pain Relevance 1.56

To determine if changes in TRPV1 staining among DRG might be due to either ectopic expression or neuronal loss, we determined the average percentage of neurons expressing TRPV1 per section (Fig. 7C).

Regulation (changes) of TRPV1 in neurons associated with dorsal root ganglion

19) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.29 Pain Relevance 0.30

We have used near saturating concentrations of capsaicin and the differences in current amplitude suggest that the TRPV1 protein content as a result of altered transcriptional regulation is higher and lower in hyper and hypoalgesic mice, respectively rather than phosphorylation state of TRPV1, where they showed prolongation of decay phase [41].

Regulation (regulation) of TRPV1 protein associated with qutenza

20) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2275252 Disease Relevance 1.14 Pain Relevance 0.53

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