INT98624

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Context Info
Confidence 0.62
First Reported 2001
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 27
Total Number 36
Disease Relevance 30.76
Pain Relevance 3.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
retina 4
optic nerve 3
astrocytes 3
B cell 2
choroid plexus 1
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 3 99.68 Very High Very High Very High
cva 90 99.16 Very High Very High Very High
Inflammation 166 98.48 Very High Very High Very High
Demyelination 195 96.68 Very High Very High Very High
Central nervous system 212 95.56 Very High Very High Very High
rheumatoid arthritis 2 93.20 High High
Spinal cord 137 92.88 High High
Neuritis 114 88.96 High High
ischemia 62 82.20 Quite High
potassium channel 10 81.28 Quite High
Disease Link Frequency Relevance Heat
Ocular Hypertension 776 100.00 Very High Very High Very High
Neuromyelitis Optica 837 99.96 Very High Very High Very High
Hydrocephalus 301 99.40 Very High Very High Very High
B-cell Lymphoma 10 99.36 Very High Very High Very High
Intracranial Hypertension 49 99.16 Very High Very High Very High
Demyelinating Disease 547 99.14 Very High Very High Very High
Refractive Errors 25 99.00 Very High Very High Very High
Injury 274 98.80 Very High Very High Very High
Hypertrophy 85 98.72 Very High Very High Very High
Disease 334 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, the results obtained in AQP4-deficient mice along with our data suggest that the dual regulation of AQP4 could serve as a compensatory host defense response to obstructive hydrocephalus.
Regulation (regulation) of AQP4 associated with hydrocephalus
1) Confidence 0.62 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.98 Pain Relevance 0.04
Further studies therefore need to consider that pharmacological regulation of AQP4 may influence hydrocephalus in different ways.
Regulation (regulation) of AQP4 associated with hydrocephalus
2) Confidence 0.62 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.67 Pain Relevance 0
The difference in affecting AQP4 protein levels may involve the ubiquitin-dependent proteasome.
Regulation (affecting) of AQP4 protein
3) Confidence 0.60 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.32 Pain Relevance 0.04
Immunohistochemical studies on retinal sections of ET-1 intravitreally injected rats did not show significant changes in AQP4 compared to HEPES-injected eyes (data not shown).
Neg (not) Regulation (changes) of AQP4 in eyes
4) Confidence 0.60 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.30 Pain Relevance 0
Effect of optic nerve crush on AQP4 in rat retinas
Regulation (Effect) of AQP4 in retinas
5) Confidence 0.58 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.44 Pain Relevance 0
In the current study we analyzed changes in AQP4 and AQP9 following optic nerve crush (ONC).
Regulation (changes) of AQP4 in optic nerve
6) Confidence 0.58 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 1.20 Pain Relevance 0.04
Thus given the multiple means to push an existing B cell repertoire to secrete autoantibodies (including NMO-IgG), it is necessary to have a better understanding of the tissue expression and the regulation of AQP4 in those tissues so that initiating and amplifying events in AQP4-specific T and B cell activation can be followed.
Regulation (regulation) of AQP4 in B cell associated with neuromyelitis optica
7) Confidence 0.51 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 0.49 Pain Relevance 0.08
With respect to the yet known data about OAP formation it is suggested to modulate the AQP4-M23 isoform to prevent the aggregation of AQP4 tetramers into higher organized structures.
Regulation (aggregation) of AQP4
8) Confidence 0.45 Published 2009 Journal Med. Hypotheses Section Abstract Doc Link 19398170 Disease Relevance 0.77 Pain Relevance 0.18
Increases in IOP appear also to affect AQP4 and ubiquitination levels distinctly in retina and optic nerve.
Spec (appear) Regulation (affect) of AQP4 in retina associated with ocular hypertension
9) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 0.92 Pain Relevance 0
Effect of intravitreal injection of ET-1 and elevated IOP on AQP4 in rat retinas
Regulation (Effect) of AQP4 in retinas associated with ocular hypertension
10) Confidence 0.44 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2559817 Disease Relevance 1.22 Pain Relevance 0
We consider that changes in ADC values and AQP4 represent phases of ICP changes following hydrocephalus development.
Regulation (changes) of AQP4 associated with hydrocephalus and cva
11) Confidence 0.39 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 1.00 Pain Relevance 0.30
2) Do the different AQP4-expressing tissues and perhaps the membrane structural organization of AQP4 influence NMO-IgG binding efficacy and thus pathogenesis?
Regulation (organization) of AQP4 associated with neuromyelitis optica
12) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2427020 Disease Relevance 1.95 Pain Relevance 0.34
2) Do the different AQP4-expressing tissues and perhaps the membrane structural organization of AQP4 influence NMO-IgG binding efficacy and thus pathogenesis?
Regulation (influence) of AQP4 associated with neuromyelitis optica
13) Confidence 0.37 Published 2008 Journal J Neuroinflammation Section Abstract Doc Link PMC2427020 Disease Relevance 1.95 Pain Relevance 0.34
No AQP4 immunoreactivity of choroid plexus was seen.
Neg (No) Regulation (immunoreactivity) of AQP4 in choroid plexus
14) Confidence 0.27 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.07 Pain Relevance 0
This study provides evidence of significant variation in the temporal and spatial regulation of AQP4 in the kaolin-induced hydrocephalic rat brain.
Regulation (regulation) of AQP4 in brain
15) Confidence 0.27 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.90 Pain Relevance 0.09
Immunoreactivity of AQP4 both in controls and hydrocephalic rats localised to the basolateral membrane of the ependymal cells lining the ventricular wall, thus confirming conserved polarisation of the AQP4 positive ependymal cells in hydrocephalus.


Regulation (Immunoreactivity) of AQP4 in ependymal cells associated with hydrocephalus
16) Confidence 0.27 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.16 Pain Relevance 0.04
AQP4 levels are significantly altered in a time and region dependent manner in kaolin-induced hydrocephalus.
Regulation (altered) of AQP4 associated with hydrocephalus
17) Confidence 0.27 Published 2010 Journal Cerebrospinal Fluid Res Section Abstract Doc Link PMC2987763 Disease Relevance 0.34 Pain Relevance 0.05
The most intense AQP4 immunoreactivity was always exhibited in the innermost portions of the retina along the vitreoretinal interface, the NFL, ganglion cell (GC) layer, and the IPL (Figure 1A).
Regulation (immunoreactivity) of AQP4 in ganglion cell associated with ganglion cysts
18) Confidence 0.27 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254964 Disease Relevance 0.29 Pain Relevance 0
With respect to the yet known data about OAP formation it is suggested to modulate the AQP4-M23 isoform to prevent the aggregation of AQP4 tetramers into higher organized structures.
Regulation (modulate) of AQP4-M23
19) Confidence 0.27 Published 2009 Journal Med. Hypotheses Section Abstract Doc Link 19398170 Disease Relevance 0.78 Pain Relevance 0.18
THE AIM OF OUR STUDY was to evaluate the changes in the tissue level of aquaporins (AQP1 and AQP4) after ethanol and capsaicin treatment in rat stomach.
Regulation (changes) of AQP4 in stomach associated with qutenza
20) Confidence 0.27 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595449 Disease Relevance 0.10 Pain Relevance 0.17

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