INT9863

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Context Info
Confidence 0.20
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 17
Total Number 17
Disease Relevance 10.58
Pain Relevance 5.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Ifih1) nucleus (Ifih1) intracellular (Ifih1)
helicase activity (Ifih1) DNA binding (Ifih1) cytoplasm (Ifih1)
Anatomy Link Frequency
liver 6
paw 6
urine 1
Ifih1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 8 99.78 Very High Very High Very High
Inflammation 100 99.16 Very High Very High Very High
Paracetamol 12 99.08 Very High Very High Very High
Analgesic 49 96.20 Very High Very High Very High
fluoxetine 1 76.60 Quite High
Hippocampus 2 67.92 Quite High
antidepressant 1 63.28 Quite High
Pain 19 57.96 Quite High
cytokine 6 57.76 Quite High
Opioid 1 48.44 Quite Low
Disease Link Frequency Relevance Heat
Depression 8 99.78 Very High Very High Very High
Pressure And Volume Under Development 45 99.68 Very High Very High Very High
Stress 64 99.44 Very High Very High Very High
INFLAMMATION 99 99.16 Very High Very High Very High
Injury 14 94.88 High High
Necrosis 10 91.48 High High
Cancer 40 91.12 High High
Death 10 89.52 High High
Hepatotoxicity 11 86.24 High High
Body Weight 25 81.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, TC(MeOH) and betulin treatment also significantly increased the activities of SOD, GR and GPx in the liver while decreasing the level of MDA in the edema paw.
Negative_regulation (decreasing) of MDA in paw associated with pressure and volume under development
1) Confidence 0.20 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19222115 Disease Relevance 0.74 Pain Relevance 0.37
The anti-inflammatory mechanism of TC(MeOH) and betulin may be related to decreasing the levels of MDA and NO in the edema paw by increasing the activities of antioxidant enzymes in the liver.
Negative_regulation (decreasing) of MDA in paw associated with pressure and volume under development and inflammation
2) Confidence 0.18 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19222115 Disease Relevance 0.80 Pain Relevance 0.33
The two saponins were shown to impede the elevation of SGPT level, decrease the MDA content and increase the GSH concentration in mouse liver.
Negative_regulation (decrease) of MDA in liver
3) Confidence 0.12 Published 1992 Journal Yao Xue Xue Bao Section Abstract Doc Link 1442065 Disease Relevance 0.26 Pain Relevance 0.15
The anti-inflammatory mechanism of MDT might be related to the decreases in the level of MDA in the edema paw via increasing the activities of SOD and GRd in the liver, and the NO level via regulating the IL-1beta production and the level of TNF-alpha in the inflamed tissues.
Negative_regulation (decreases) of MDA in liver associated with pressure and volume under development and inflammation
4) Confidence 0.09 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19606516 Disease Relevance 1.25 Pain Relevance 0.51
Analyzing through multiple linear correlation, we showed that the lowering of SGPT was negatively related to the increase of GSH, positively related to the decrease of MDA in mice given CCl4 or acetaminophen in combination with ASI or SK.
Negative_regulation (decrease) of MDA associated with paracetamol
5) Confidence 0.09 Published 1992 Journal Yao Xue Xue Bao Section Abstract Doc Link 1442065 Disease Relevance 0.23 Pain Relevance 0.17
The anti-inflammatory mechanism of FL and FM might be related to the decrease in the level of MDA in the edema paw via increasing the activities of GPx and GRx in the liver and decreasing the NO level in the edema paw.
Negative_regulation (decrease) of MDA in paw associated with pressure and volume under development and inflammation
6) Confidence 0.09 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503477 Disease Relevance 0.92 Pain Relevance 0.43
Treatment with TFA (160, 80, and 40 mg/kg) significantly ameliorated mice escape-directed behavioral impairment induced by PSD, markedly reduced MDA levels, and increased the activity of SOD, GSH-Px close to normal levels.
Negative_regulation (reduced) of MDA associated with depression
7) Confidence 0.09 Published 2009 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 19248161 Disease Relevance 0.98 Pain Relevance 0.44
On the other hand, MDT increased the activities of SOD and GRd in liver tissues and decreased the MDA level in the edema paw at the 3rd hour after lambda-carrageenan-induced inflammation.
Negative_regulation (decreased) of MDA in paw associated with pressure and volume under development and inflammation
8) Confidence 0.08 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19606516 Disease Relevance 1.31 Pain Relevance 0.58
The anti-inflammatory mechanisms of ST1 might be related to the decrease in the level of MDA, iNOS, and COX-2 in the edema paw via increasing the activities of CAT, SOD, and GPx in the liver through the suppression of TNF-alpha and NO.
Negative_regulation (decrease) of MDA in liver associated with pressure and volume under development and inflammation
9) Confidence 0.08 Published 2010 Journal J. Agric. Food Chem. Section Abstract Doc Link 20507140 Disease Relevance 0.96 Pain Relevance 0.30
The anti-inflammatory mechanism of WET might be related to the decrease in the level of MDA in the edema paw via increasing the activities of SOD, GPx and GRx in the liver.


Negative_regulation (decrease) of MDA in liver
10) Confidence 0.06 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19703536 Disease Relevance 0 Pain Relevance 0
WET decreased the paw edema at the third, fourth and fifth hour after carr administration, and increased the activities of SOD, GPx and GRx in the liver tissue and decreased the MDA level in the edema paw at the third hour after carr injection.
Negative_regulation (decreased) of MDA in paw
11) Confidence 0.04 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19703536 Disease Relevance 0 Pain Relevance 0
Post treatment with the protein after toxin administration decreased MDA level (10.17 ± 0.52 nmol/g tissue) also.
Negative_regulation (decreased) of MDA
12) Confidence 0.04 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1868763 Disease Relevance 0 Pain Relevance 0
However, the pre-intake of carnosine or histidine significantly alleviated acetaminophen-induced oxidative stress by increasing GSH content, decreasing MDA, ROS, and GSSG formations, and retaining activity of GPX, catalase, and SOD in liver (P < 0.05).
Negative_regulation (decreasing) of MDA in liver associated with stress and paracetamol
13) Confidence 0.04 Published 2009 Journal J. Food Sci. Section Abstract Doc Link 19799668 Disease Relevance 0.55 Pain Relevance 0.66
In contrast to the effect of CR on increasing MDA, protein oxidation following CR is decreased in G93A mice.
Negative_regulation (effect) of MDA
14) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827549 Disease Relevance 0.42 Pain Relevance 0
The anti-inflammatory mechanism of AGT might be related to the decrease in the level of MDA in the edema paw via increasing the activities of SOD, GPx and GRx in the liver.
Negative_regulation (decrease) of MDA in liver associated with pressure and volume under development and inflammation
15) Confidence 0.02 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17616291 Disease Relevance 0.87 Pain Relevance 0.53
In the anti-inflammatory test, AGT (0.5 and 1.0 g/kg) decreased the paw edema at the third, fourth, fifth and sixth hour after lambda-carrageenan administration, and increased the activities of SOD, GPx and GRx in the liver tissue and decreased the MDA level in the edema paw at the third hour after lambda-carrageenan injection.
Negative_regulation (decreased) of MDA in paw associated with pressure and volume under development and inflammation
16) Confidence 0.01 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17616291 Disease Relevance 0.84 Pain Relevance 0.55
The A. paniculata methanol extract significantly lowered MDA levels and raised the total antioxidant status in urine samples 24 hours after oral administration [122].
Negative_regulation (lowered) of MDA in urine
17) Confidence 0.00 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.45 Pain Relevance 0.04

General Comments

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