INT98633

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.79
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (EGR1) nucleus (EGR1) intracellular (EGR1)
DNA binding (EGR1) cytoplasm (EGR1)
EGR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 6 88.72 High High
epidural 1 88.28 High High
cINOD 10 79.68 Quite High
Inflammatory response 5 79.20 Quite High
COX-2 inhibitor 2 77.96 Quite High
addiction 12 72.32 Quite High
aspirin 2 53.00 Quite High
Inflammation 12 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Inflammatory Response Syndrome 22 82.48 Quite High
Injury 3 72.44 Quite High
Ulcers 2 64.04 Quite High
Adult Respiratory Distress Syndrome 20 62.08 Quite High
Peptic Ulcer 2 57.48 Quite High
INFLAMMATION 15 51.76 Quite High
Esophageal Cancer 13 50.00 Quite Low
Anastomotic Leak 9 5.00 Very Low Very Low Very Low
Pneumonia 8 5.00 Very Low Very Low Very Low
Sepsis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IND pre-treatment significantly inhibited VEGF-induced Egr-1 mRNA expression by 29+/-4% (P<0.01) and protein expression by 41+/-8% (P<0.05).
Negative_regulation (inhibited) of Transcription (expression) of Egr-1
1) Confidence 0.43 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595463 Disease Relevance 0.25 Pain Relevance 0.37
NS-398 inhibited VEGF-induced Egr-1 mRNA and protein expression by 23+/-3% and 35+/-4%, respectively (both P<0.01).
Negative_regulation (inhibited) of Transcription (expression) of Egr-1
2) Confidence 0.42 Published 2001 Journal J. Physiol. Paris Section Abstract Doc Link 11595463 Disease Relevance 0.18 Pain Relevance 0.24
We measured serum mRNA levels of 11 genes (MMP9, CRP, HMGB1, MUC1, EGR1, PBEF1, PDGFA, TGF-?
Negative_regulation (measured) of Transcription (levels) of EGR1
3) Confidence 0.37 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.37 Pain Relevance 0.50

General Comments

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