INT9864

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Context Info
Confidence 0.11
First Reported 1992
Last Reported 1996
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.37
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (B3gat3) molecular_function (B3gat3) biological_process (B3gat3)
Anatomy Link Frequency
liver 2
B3gat3 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 99.28 Very High Very High Very High
carbamazepine 11 98.10 Very High Very High Very High
anticonvulsant 1 92.88 High High
Lamotrigine 1 87.20 High High
antidepressant 1 82.28 Quite High
tricyclic antidepressant 1 79.68 Quite High
depression 1 51.00 Quite High
Trigeminal neuralgia 1 48.64 Quite Low
antiepileptic Drug 1 46.32 Quite Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 4 93.68 High High
Manic Depressive Disorder 1 51.00 Quite High
Headache 1 48.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ful pretreatment had no influence on liver UDP-glucuronic acid concentration, but increased hepatic glucuronyltransferase activity towards AA.
Positive_regulation (increased) of glucuronyltransferase in liver associated with paracetamol
1) Confidence 0.11 Published 1992 Journal Zhongguo Yao Li Xue Bao Section Abstract Doc Link 1442100 Disease Relevance 0.32 Pain Relevance 0.93
Carbamazepine is a potent inducer of CYP3A4 and other oxidative enzyme system in the liver, and it may also increase glucuronyltransferase activity.
Spec (may) Positive_regulation (increase) of glucuronyltransferase in liver associated with carbamazepine
2) Confidence 0.01 Published 1996 Journal Clin Pharmacokinet Section Abstract Doc Link 8877250 Disease Relevance 0.05 Pain Relevance 0.56

General Comments

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