INT98643

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Context Info
Confidence 0.47
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.16
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (FGF23) extracellular space (FGF23) extracellular region (FGF23)
Anatomy Link Frequency
fibroblast 2
FGF23 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 68.96 Quite High
imagery 3 49.60 Quite Low
Disease Link Frequency Relevance Heat
Cancer 8 99.98 Very High Very High Very High
Hypophosphatemia 3 99.84 Very High Very High Very High
Rickets 13 99.42 Very High Very High Very High
Autosomal Disorder 1 82.96 Quite High
Malignant Neoplastic Disease 2 75.00 Quite High
Neurilemmoma 2 75.00 Quite High
Pain 2 68.96 Quite High
Muscle Disease 1 67.52 Quite High
Muscle Weakness 1 60.92 Quite High
Fatigue 1 60.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oncogenic osteomalacia (OOM) is characterised by tumour production of fibroblast growth factor 23 (FGF23) that results in hypophosphataemia and renal phosphate wasting, reduced 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) synthesis and osteomalacia.
Positive_regulation (results) of Gene_expression (production) of FGF23 in fibroblast associated with cancer, rickets and hypophosphatemia
1) Confidence 0.47 Published 2008 Journal Eur. J. Endocrinol. Section Abstract Doc Link 18230836 Disease Relevance 0.90 Pain Relevance 0.07
HMS-97 cells might be useful for further studies that aim to determine the genetic mechanism that leads to the observed PHEX and FGF-23 expression, both of which might have a direct role in the pathogenesis of oncogenic osteomalacia.
Positive_regulation (leads) of Gene_expression (expression) of FGF-23 associated with rickets
2) Confidence 0.30 Published 2001 Journal Bone Section Abstract Doc Link 11595624 Disease Relevance 1.26 Pain Relevance 0.06

General Comments

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