INT98648

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Context Info
Confidence 0.50
First Reported 2001
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.03
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mdk) extracellular region (Mdk)
Anatomy Link Frequency
liver 2
lung 2
Mdk (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 9 99.34 Very High Very High Very High
Endep 7 98.02 Very High Very High Very High
Kinase C inhibitor 1 96.04 Very High Very High Very High
antidepressant 8 92.92 High High
Spinal cord 17 91.84 High High
Thermal hyperalgesia 19 90.08 High High
fluoxetine 1 88.20 High High
intrathecal 6 83.92 Quite High
withdrawal 10 81.68 Quite High
GABAergic 5 67.80 Quite High
Disease Link Frequency Relevance Heat
Nociception 19 99.58 Very High Very High Very High
INFLAMMATION 10 99.34 Very High Very High Very High
Liver Cancer 12 98.94 Very High Very High Very High
Apoptosis 149 97.40 Very High Very High Very High
Breast Cancer 3 96.00 Very High Very High Very High
Hyperalgesia 21 90.08 High High
Stress 2 85.44 High High
Cancer 102 76.64 Quite High
Glioblastoma 2 76.12 Quite High
Neurological Disease 1 73.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next investigated whether the reduced inflammatory nociception was associated with reduced ERK activation in the DN MEK mice.
Spec (whether) Negative_regulation (reduced) of Spec (whether) Positive_regulation (activation) of DN MEK associated with nociception and inflammation
1) Confidence 0.50 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.85 Pain Relevance 0.70
Sorafenib inhibited activation of the Raf/MEK/ERK pathway in a number of cell lines in Western blot assays and pERK immunoassays (Wilhelm et al 2004).
Negative_regulation (inhibited) of Positive_regulation (activation) of MEK
2) Confidence 0.15 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661649 Disease Relevance 0.28 Pain Relevance 0
Treatment of human liver cancer cells with MEK1/2 inhibitor U0126 or PD98059, which inhibits MEK-MAPK activation, leads to a time- and dose-dependent reduction in cell proliferation and viability.
Negative_regulation (inhibits) of Positive_regulation (activation) of MEK in liver associated with liver cancer
3) Confidence 0.15 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.89 Pain Relevance 0.03
Downstream of TrkB, we further show that the MAPK pathway involving MEK/ERK activation is a crucial and universal regulator of BDNF-induced gene expression.
Negative_regulation (regulator) of Positive_regulation (activation) of MEK
4) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0.07 Pain Relevance 0.03
Pharmacological inhibition of ERK activation (e.g. employing the MEK inhibitor U0126) has been shown to enhance chemotherapy-induced apoptosis of the lung, ovarian and breast carcinoma cell lines (MacKeigan et al. 2000, McDaid & Horwitz 2001).
Negative_regulation (inhibition) of Positive_regulation (activation) of MEK in lung associated with breast cancer and apoptosis
5) Confidence 0.07 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.79 Pain Relevance 0.12
Amitriptyline-induced GDNF release was inhibited by U0126 (10 microM), a mitogen-activated protein kinase (MAPK)-extracellular signal-related kinase (ERK) kinase (MEK) inhibitor, but was not inhibited by H-89 (1 microM), a protein kinase A inhibitor, calphostin C (100 nM), a protein kinase C inhibitor and PD 169316 (10 microM), a p38 mitogen-activated protein kinase inhibitor.
Negative_regulation (inhibitor) of Positive_regulation (-extracellular) of MEK associated with endep and kinase c inhibitor
6) Confidence 0.02 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.15 Pain Relevance 0.67

General Comments

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