INT98650

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.94
Pain Relevance 2.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
spinal 2
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endep 21 100.00 Very High Very High Very High
antidepressant 24 99.50 Very High Very High Very High
fluoxetine 3 99.38 Very High Very High Very High
Pain 2 95.44 Very High Very High Very High
Dorsal horn neuron 2 94.40 High High
withdrawal 3 92.24 High High
Kinase C inhibitor 3 90.32 High High
intrathecal 2 86.96 High High
spinal dorsal horn 1 75.00 Quite High
Dorsal horn 4 59.92 Quite High
Disease Link Frequency Relevance Heat
Nociception 3 99.84 Very High Very High Very High
Glioblastoma 6 97.76 Very High Very High Very High
Pain 2 95.44 Very High Very High Very High
Lumbar Puncture Related Headaches 1 46.32 Quite Low
Ganglion Cysts 2 36.68 Quite Low
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we demonstrated that long-term use of antidepressant treatment significantly increased GDNF mRNA expression and GDNF release in time- and concentration-dependent manners in rat C6 glioblastoma cells.
Positive_regulation (increased) of Localization (release) of GDNF associated with antidepressant and glioblastoma
1) Confidence 0.68 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.17 Pain Relevance 0.52
Furthermore, following treatment with antidepressants belonging to several different classes (amitriptyline, clomipramine, mianserin, fluoxetine and paroxetine) significantly increased GDNF release, but which did not occur after treatment with non-antidepressant psychotropic drugs (haloperidol, diazepam and diphenhydramine).
Positive_regulation (increased) of Localization (release) of GDNF associated with antidepressant, endep and fluoxetine
2) Confidence 0.68 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.16 Pain Relevance 0.64
Amitriptyline-induced GDNF release was inhibited by U0126 (10 microM), a mitogen-activated protein kinase (MAPK)-extracellular signal-related kinase (ERK) kinase (MEK) inhibitor, but was not inhibited by H-89 (1 microM), a protein kinase A inhibitor, calphostin C (100 nM), a protein kinase C inhibitor and PD 169316 (10 microM), a p38 mitogen-activated protein kinase inhibitor.
Positive_regulation (Amitriptyline-induced) of Localization (release) of GDNF associated with endep and kinase c inhibitor
3) Confidence 0.49 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.16 Pain Relevance 0.66
We further suggest that the endogenous release of GDNF and BDNF, triggered by nociceptive stimuli, is involved in the induction of changes in spinal nociceptive transmission as in various pain states.
Positive_regulation (triggered) of Localization (release) of GDNF in spinal associated with nociception and pain
4) Confidence 0.35 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15899262 Disease Relevance 0.45 Pain Relevance 0.46

General Comments

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