INT98651

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.97
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Anatomy Link Frequency
sensory neurons 2
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 107 100.00 Very High Very High Very High
Endep 7 100.00 Very High Very High Very High
trigeminal ganglion 59 98.88 Very High Very High Very High
Calcitonin gene-related peptide 96 98.32 Very High Very High Very High
Kinase C inhibitor 1 95.72 Very High Very High Very High
antidepressant 8 94.16 High High
qutenza 52 93.56 High High
Inflammation 6 93.04 High High
fluoxetine 1 76.32 Quite High
withdrawal 1 69.80 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 73 98.88 Very High Very High Very High
Nociception 10 93.56 High High
INFLAMMATION 5 93.04 High High
Glioblastoma 2 75.00 Quite High
Nervous System Injury 3 73.76 Quite High
Injury 23 5.00 Very Low Very Low Very Low
Hyperalgesia 7 5.00 Very Low Very Low Very Low
Headache 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggested that amitriptyline-induced GDNF synthesis and release occurred at the transcriptional level, and may be regulated by MEK/MAPK signalling.
Regulation (regulated) of Positive_regulation (amitriptyline-induced) of GDNF associated with endep
1) Confidence 0.44 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.14 Pain Relevance 0.61
For sensory neurons, increased levels of NGF and GDNF do not affect the number of regenerated neurons 1 cm distal to a lesion at 4 weeks post-lesion but do cause changes in the expression of markers for different populations of nociceptive neurons.
Neg (not) Regulation (affect) of Positive_regulation (increased) of GDNF in sensory neurons associated with nociception and nerve growth factor
2) Confidence 0.24 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18973572 Disease Relevance 0.25 Pain Relevance 0.25
Both the NGF- and GDNF-induced upregulation of TRPV1 appears to be translationally regulated, as neither of these growth factors altered TRPV1 mRNA levels.
Spec (appears) Regulation (regulated) of Positive_regulation (upregulation) of GDNF-induced associated with nerve growth factor
3) Confidence 0.20 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.59 Pain Relevance 0.71

General Comments

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