INT98652

Context Info Confidence 0.40 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.42 Pain Relevance 2.15

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)

Anatomy Link Frequency oligodendrocytes 3 glial cell 2 Astrocytes 1 Ntf3 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Nerve growth factor 108 100.00 antidepressant 8 99.66 Endep 7 99.38 intrathecal 4 96.72 headache 10 82.12 withdrawal 1 73.68 fluoxetine 1 67.16 cva 38 59.24 Kinase C inhibitor 1 48.40 imagery 4 5.00

Disease Link Frequency Relevance Heat Glioblastoma 2 99.56 Hydrocephalus 56 92.96 Papilledema 4 83.32 Headache 10 82.12 Vomiting 4 59.92 Intracranial Hypertension 36 59.24 Bacterial Infection 4 32.76 Hypoxia 6 5.00 Brain Injury 6 5.00 Disease 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Astrocytes and oligodendrocytes can be induced to secrete NGF and NT-3 [13,14], and these cells are the most likely the source of NGF and NT-3 in CSF.

Positive_regulation (induced) of Localization (secrete) of NT-3 in oligodendrocytes associated with nerve growth factor

1) Confidence 0.40 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.62 Pain Relevance 0.78

Astrocytes and oligodendrocytes can be induced to secrete NGF and NT-3 [13,14], and these cells are the most likely the source of NGF and NT-3 in CSF.

Positive_regulation (induced) of in Astrocytes Localization (secrete) of NT-3 in oligodendrocytes associated with nerve growth factor

2) Confidence 0.14 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.62 Pain Relevance 0.78

Antidepressant drug treatments induce glial cell line-derived neurotrophic factor (GDNF) synthesis and release in rat C6 glioblastoma cells.

Positive_regulation (induce) of Localization (release) of neurotrophic factor in glial cell associated with antidepressant and glioblastoma

3) Confidence 0.11 Published 2001 Journal J. Neurochem. Section Title Doc Link 11595754 Disease Relevance 0.18 Pain Relevance 0.60

General Comments

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