INT98653

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.31
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf)
Gdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endep 14 99.82 Very High Very High Very High
Kinase C inhibitor 2 96.96 Very High Very High Very High
antidepressant 16 96.52 Very High Very High Very High
fluoxetine 2 91.80 High High
withdrawal 2 85.28 High High
Disease Link Frequency Relevance Heat
Glioblastoma 4 79.72 Quite High
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Amitriptyline-induced GDNF release was inhibited by U0126 (10 microM), a mitogen-activated protein kinase (MAPK)-extracellular signal-related kinase (ERK) kinase (MEK) inhibitor, but was not inhibited by H-89 (1 microM), a protein kinase A inhibitor, calphostin C (100 nM), a protein kinase C inhibitor and PD 169316 (10 microM), a p38 mitogen-activated protein kinase inhibitor.
Negative_regulation (inhibited) of Localization (release) of GDNF associated with endep and kinase c inhibitor
1) Confidence 0.57 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.15 Pain Relevance 0.70
Amitriptyline-induced GDNF release was inhibited by U0126 (10 microM), a mitogen-activated protein kinase (MAPK)-extracellular signal-related kinase (ERK) kinase (MEK) inhibitor, but was not inhibited by H-89 (1 microM), a protein kinase A inhibitor, calphostin C (100 nM), a protein kinase C inhibitor and PD 169316 (10 microM), a p38 mitogen-activated protein kinase inhibitor.
Negative_regulation (inhibited) of Localization (release) of GDNF associated with endep and kinase c inhibitor
2) Confidence 0.57 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11595754 Disease Relevance 0.15 Pain Relevance 0.65

General Comments

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