INT98685

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 28
Total Number 28
Disease Relevance 9.46
Pain Relevance 5.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGES) signal transduction (PTGES) cytoplasm (PTGES)
Anatomy Link Frequency
amnion 8
chondrocytes 4
POA 2
HMSM 2
neurons 2
PTGES (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 214 100.00 Very High Very High Very High
cytokine 147 100.00 Very High Very High Very High
Spinal cord 2 99.24 Very High Very High Very High
rheumatoid arthritis 10 99.16 Very High Very High Very High
Osteoarthritis 271 97.08 Very High Very High Very High
COX-2 inhibitor 41 96.92 Very High Very High Very High
cINOD 22 95.76 Very High Very High Very High
Pain 15 94.76 High High
Dismenorea 8 94.68 High High
Hyperalgesia 6 94.48 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 255 100.00 Very High Very High Very High
Nociception 2 99.80 Very High Very High Very High
Glioma 2 99.56 Very High Very High Very High
Rheumatoid Arthritis 10 99.16 Very High Very High Very High
Bacterial Infection 7 98.48 Very High Very High Very High
Colon Cancer 5 98.40 Very High Very High Very High
Osteoarthritis 295 97.08 Very High Very High Very High
Disorder Of Lipid Metabolism 5 96.00 Very High Very High Very High
Fever 5 95.20 Very High Very High Very High
Pain 14 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In inflammation and clinically relevant biological systems, mPGES-1 expression, like COX-2 expression was induced in cell context- and time-dependent manner, consistent with the kinetics of PGE(2) synthesis.
Positive_regulation (induced) of Gene_expression (expression) of mPGES-1 associated with inflammation
1) Confidence 0.68 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20067770 Disease Relevance 0.58 Pain Relevance 0.39
Ellagic acid suppressed the lipopolysaccharide-induced increase in protein expression of cyclo-oxygenase-2 (COX-2), microsomal PGE synthase-1 (mPGEs-1) and cytosolic phospholipase A2alpha (cPLA2alpha), while it had no effect on the constitutively expressed COX-1 protein.
Positive_regulation (increase) of Gene_expression (expression) of microsomal PGE synthase-1
2) Confidence 0.67 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.58 Pain Relevance 0.21
Exposure to LPS strongly induced mPGES-1 expression.
Positive_regulation (induced) of Gene_expression (expression) of mPGES-1
3) Confidence 0.66 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.52 Pain Relevance 0.36
Nuclear factor-kappa B regulates inducible prostaglandin E synthase expression in human amnion mesenchymal cells.
Positive_regulation (inducible) of Gene_expression (expression) of prostaglandin E synthase in amnion associated with cytokine
4) Confidence 0.65 Published 2008 Journal Biol. Reprod. Section Title Doc Link 17928629 Disease Relevance 0.19 Pain Relevance 0.31
In parallel, increased expression of the PTGS2 and PTGES proteins was observed.
Positive_regulation (increased) of Gene_expression (expression) of PTGES
5) Confidence 0.65 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.15 Pain Relevance 0.24
It has been shown that mPGES-1 expression is upregulated in animal models of rheumatoid arthritis and in patients suffering from OA [4,5] and is downregulated by anti-inflammatory drugs [6,7]. mPGES-1 expression is regulated by several transcription factors, such as early growth response-1 (Egr-1) and NF-?
Positive_regulation (upregulated) of Gene_expression (expression) of mPGES-1 associated with inflammation, cinod, rheumatoid arthritis and osteoarthritis
6) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 1.16 Pain Relevance 0.67
Interestingly, when HNE was maintained for 14 hours in cultured chondrocytes, through repeated treatments at intervals of 2 hours, the aldehyde induced both COX-2 and mPGES-1 expression up to 24 hours and consequently abolished their decrease.
Positive_regulation (induced) of Gene_expression (expression) of mPGES-1 in chondrocytes
7) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.38 Pain Relevance 0.21
Numerous cytokines and growth factors are known to upregulate mPGES-1 production via Egr-1 activation [38].
Positive_regulation (upregulate) of Gene_expression (production) of mPGES-1 associated with cytokine
8) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.24 Pain Relevance 0.17
On the contrary, we do not exclude the possibility that the increase of COX-2 and mPGES-1 expression up to 24 hours may coincide with the inflammatory resolution.
Positive_regulation (increase) of Gene_expression (expression) of mPGES-1 associated with inflammation
9) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.26 Pain Relevance 0.18
We hypothesized that NFkappaB might regulate cytokine-induced PTGES expression in amnion cells.
Positive_regulation (induced) of Gene_expression (expression) of PTGES in amnion associated with cytokine
10) Confidence 0.57 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.16 Pain Relevance 0.26
In conclusion, our results support a role for NFkappaB in cytokine-induced PTGES expression in amnion mesenchymal cells in vitro.
Positive_regulation (role) of Gene_expression (expression) of PTGES in amnion associated with cytokine
11) Confidence 0.57 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0 Pain Relevance 0.11
In conclusion, our results support a role for NFkappaB in cytokine-induced PTGES expression in amnion mesenchymal cells in vitro.
Positive_regulation (induced) of Gene_expression (expression) of PTGES in amnion associated with cytokine
12) Confidence 0.57 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0 Pain Relevance 0.11
Thus, COX-2 expression and mPGES-1 expression are co-ordinately up-regulated in lower segment myometrium with term labour and with IL-1beta treatment in HMSM cells.
Positive_regulation (up-regulated) of Gene_expression (expression) of mPGES-1 in HMSM
13) Confidence 0.49 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17105783 Disease Relevance 0 Pain Relevance 0
Expression of the LASS4, PTGES, ZDHHC1 and ZDHHC8 transcripts involved in lipid biosynthesis, metabolism and modification were all increased.


Positive_regulation (increased) of Gene_expression (Expression) of PTGES
14) Confidence 0.49 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.30 Pain Relevance 0.10
It is interesting that early growth response-1 (Egr-1) protein, which is a key transcription factor in regulating the inducible expression of microsomal PGE synthase 1 (mPGES-1) and therefore promotes PGE2 release [40], is also significantly reduced by an HO-1 inducer, CoPP, in IL-1?
Positive_regulation (inducible) of Gene_expression (expression) of mPGES-1
15) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.25 Pain Relevance 0.12
Ellagic acid suppressed the lipopolysaccharide-induced increase in protein expression of cyclo-oxygenase-2 (COX-2), microsomal PGE synthase-1 (mPGEs-1) and cytosolic phospholipase A2alpha (cPLA2alpha), while it had no effect on the constitutively expressed COX-1 protein.
Positive_regulation (increase) of Gene_expression (expression) of mPGEs-1
16) Confidence 0.48 Published 2010 Journal Br. J. Nutr. Section Abstract Doc Link 19948080 Disease Relevance 0.58 Pain Relevance 0.21
Increased production of prostaglandin E(2) (PGE(2)) by the combined activities of cyclooxygenase-2 (COX-2) and microsomal glutathione S-transferase 1-like 1 (MGST1-L1) enhances the progression of colorectal cancer.
Positive_regulation (Increased) of Gene_expression (production) of microsomal glutathione S-transferase 1-like 1 associated with colon cancer
17) Confidence 0.48 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12818365 Disease Relevance 0.40 Pain Relevance 0.08
Prostaglandin E synthase (PTGES, also known as microsomal PGE synthase-1) acts downstream of PTGS2 and is inducibly expressed in most systems.
Positive_regulation (inducibly) of Gene_expression (expressed) of Prostaglandin E synthase
18) Confidence 0.47 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.18 Pain Relevance 0.27
With amnion mesenchymal cells, we found that proinflammatory cytokines coordinately upregulated PTGS2 and PTGES mRNA expression.
Positive_regulation (upregulated) of Gene_expression (expression) of PTGES in mesenchymal cells associated with cytokine
19) Confidence 0.47 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.15 Pain Relevance 0.25
Prostaglandin E synthase (PTGES, also known as microsomal PGE synthase-1) acts downstream of PTGS2 and is inducibly expressed in most systems.
Positive_regulation (inducibly) of Gene_expression (expressed) of PTGES
20) Confidence 0.47 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17928629 Disease Relevance 0.18 Pain Relevance 0.27

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