INT98697

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 7.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg1a) plasma membrane (Dsg1a)
Anatomy Link Frequency
skin 2
Dsg1a (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 36.00 Quite Low
corticosteroid 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 35 99.98 Very High Very High Very High
Bullous Skin Disease 258 99.80 Very High Very High Very High
Targeted Disruption 172 99.00 Very High Very High Very High
Blister 148 97.16 Very High Very High Very High
Acantholysis 9 94.64 High High
Adhesions 54 90.60 High High
Skin Diseases 4 84.92 Quite High
Monilethrix 4 81.64 Quite High
Congenital Anomalies 4 76.96 Quite High
Streptococcus Infection 4 75.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next, we wanted to evaluate whether or not superficial expression of Dsg2 had an effect on Dsg1 fate and localization in response to PF Ig.
Spec (whether) Regulation (effect) of Dsg1 associated with bullous skin disease
1) Confidence 0.45 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.40 Pain Relevance 0
Despite the extensive cleavage of Dsg1 by ETA, as shown by Western blotting above, we did not observe a dramatic change in the Dsg1 pattern in either WT or Tg skin.
Regulation (change) of Dsg1 in skin associated with targeted disruption
2) Confidence 0.45 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 0.57 Pain Relevance 0
In PV and PF, the AAb target the extracellular portions of desmoglein 3 (Dsg3) and Dsg1, respectively.
Regulation (target) of Dsg1 associated with bullous skin disease
3) Confidence 0.39 Published 2001 Journal Skin Pharmacol. Appl. Skin Physiol. Section Abstract Doc Link 11598441 Disease Relevance 2.10 Pain Relevance 0
In pemphigus foliaceus (PF), patients develop pathogenic autoantibodies that target Dsg1 and promote cell-cell disadhesion in the superficial epidermis, where Dsg1 is highly expressed, but which lacks Dsg3 and Dsg2.
Regulation (target) of Dsg1 in epidermis associated with bullous skin disease
4) Confidence 0.27 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.60 Pain Relevance 0
The results obtained here provide some insights into the pathomechanisms of diseases targeting Dsg1.

2.

Regulation (targeting) of Dsg1 associated with disease
5) Confidence 0.27 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.66 Pain Relevance 0

General Comments

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