INT987

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1978
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 37
Total Number 38
Disease Relevance 10.53
Pain Relevance 11.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TRH) extracellular region (TRH) plasma membrane (TRH)
nucleus (TRH) cell-cell signaling (TRH) cytoplasm (TRH)
Anatomy Link Frequency
pituitary 3
spinal 2
thyroid 2
epidermis 2
gut 1
TRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 43 100.00 Very High Very High Very High
Neuropeptide 30 100.00 Very High Very High Very High
Neurotransmitter 28 100.00 Very High Very High Very High
Calcitonin gene-related peptide 20 100.00 Very High Very High Very High
substance P 13 100.00 Very High Very High Very High
Clonidine 7 100.00 Very High Very High Very High
Enkephalin 7 100.00 Very High Very High Very High
Cholecystokinin 6 100.00 Very High Very High Very High
tramadol 6 100.00 Very High Very High Very High
Opioid 5 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pituitary Cancer 40 99.96 Very High Very High Very High
Obesity 18 99.58 Very High Very High Very High
Increased Venous Pressure Under Development 8 99.32 Very High Very High Very High
Thyroid Disease 5 99.28 Very High Very High Very High
Hypernatremia 4 99.28 Very High Very High Very High
Stress 93 99.04 Very High Very High Very High
Cv General 3 Under Development 4 98.36 Very High Very High Very High
Injury 9 98.28 Very High Very High Very High
Hyperlipidemia 2 98.24 Very High Very High Very High
Hypopituitarism 4 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After nine months of Br, despite return of adequate gonadotropin and GH secretion as assessed by repeat ITT-TRH-GnRH-clonidine, pooled 12 hour nocturnal spontaneous GH secretion, and clinical progression of puberty, there was no linear "catch-up growth" (growth rate = 4.4 cm/yr and height 4.2 SD below the mean for age).
Localization (secretion) of TRH associated with clonidine
1) Confidence 0.78 Published 1994 Journal J Pediatr Endocrinol Section Abstract Doc Link 8186829 Disease Relevance 0.48 Pain Relevance 0.20
Extended release formulation of tramadol hydrochloride (TRH) based on osmotic technology was developed and evaluated.
Localization (release) of TRH associated with tramadol
2) Confidence 0.75 Published 2009 Journal Acta Pharm Section Abstract Doc Link 19304555 Disease Relevance 0 Pain Relevance 0.17
TRH release was directly proportional to the levels of plasticizer but inversely proportional to the levels of swellable polymer and coat thickness of SPM.
Localization (release) of TRH
3) Confidence 0.75 Published 2009 Journal Acta Pharm Section Abstract Doc Link 19304555 Disease Relevance 0 Pain Relevance 0.19
The developed formulation provided more prolonged and controlled TRH release compared to the marketed formulation.
Localization (release) of TRH
4) Confidence 0.75 Published 2009 Journal Acta Pharm Section Abstract Doc Link 19304555 Disease Relevance 0 Pain Relevance 0.18
[Effect of combined administration of TRH and dexamethasone in pregnant women and the course of their pregnancy].
Localization (administration) of TRH associated with dexamethasone
5) Confidence 0.74 Published 1998 Journal Ceska Gynekol Section Title Doc Link 10535166 Disease Relevance 0.47 Pain Relevance 0.11
The syndrome is characterized by: adipsia-hypodipsia (5/5 patients), recurrent hypernatremia (5/5), obesity (4/5), inability to excrete a water load (5/5), lack of growth hormone release in response to provocative stimuli (4/4), blunted thyrotropin releasing hormone responses (3/4), hypothyroidism (2/4), and hyperlipemia associated with hypernatremic crisis (1/1).
Localization (releasing) of thyrotropin releasing hormone associated with syndrome, thyroid disease, obesity, hyperlipidemia and hypernatremia
6) Confidence 0.73 Published 1982 Journal Pediatrics Section Abstract Doc Link 6808452 Disease Relevance 0.83 Pain Relevance 0.09
Thyrotropin-releasing hormone improves neurologic recovery after spinal trauma in cats.
Localization (releasing) of Thyrotropin-releasing hormone in spinal associated with injury
7) Confidence 0.73 Published 1981 Journal N. Engl. J. Med. Section Title Doc Link 6792542 Disease Relevance 0.70 Pain Relevance 0.57
Role of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic hyperemia.
Localization (releasing) of thyrotropin-releasing hormone associated with qutenza, increased venous pressure under development and calcitonin gene-related peptide
8) Confidence 0.73 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10513557 Disease Relevance 0.19 Pain Relevance 0.77
Involvement of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic cytoprotection.
Localization (releasing) of thyrotropin-releasing hormone associated with qutenza and calcitonin gene-related peptide
9) Confidence 0.73 Published 2003 Journal Eur. J. Pharmacol. Section Title Doc Link 14575802 Disease Relevance 0.08 Pain Relevance 0.77
The transmitter mechanisms for these effects include dopamine, gamma-aminobutyric acid, thyrotropin-releasing hormone, neurotensin, enkephalins, and endorphins.
Localization (releasing) of thyrotropin-releasing hormone associated with dopamine and enkephalin
10) Confidence 0.73 Published 1991 Journal Dig. Dis. Sci. Section Abstract Doc Link 1935503 Disease Relevance 0 Pain Relevance 0.38
In many medullary raphé neurones, both thyrotropin-releasing hormone (TRH) and substance P are colocalized with 5-HT, and these neurotransmitters are also excitatory to hypoglossal [20] and spinal motor neurones [21].
Localization (colocalized) of thyrotropin-releasing hormone in spinal associated with neurotransmitter and substance p
11) Confidence 0.73 Published 2001 Journal Respir Res Section Body Doc Link PMC59518 Disease Relevance 0 Pain Relevance 0.13
The peptides are discussed in three subgroups: I) the opioid peptides, which include beta-endorphin, the enkephalins, and dynorphin; II) the pituitary releasing hormones, most of which are wide-spread in the brain and include corticotropin-releasing hormone, luteinizing hormone-releasing hormone, somatostatin, and thyrotropin-releasing hormone; and III) a selection of 12 other peptides potentially important for neurological function, including vasopressin, oxytocin, substance P, cholecystokinin, bombesin, neurotensin, renin, angiotensin, vasoactive intestinal polypeptide, neuropeptide Y, calcitonin gene-related peptide, and calcitonin.
Localization (releasing) of thyrotropin-releasing hormone in pituitary associated with somatostatin, enkephalin, calcitonin gene-related peptide, dynorphin, neuropeptide, opioid, cholecystokinin and substance p
12) Confidence 0.73 Published 1991 Journal Neurosurg Rev Section Abstract Doc Link 1870724 Disease Relevance 0.06 Pain Relevance 0.51
[Thyrotropin-releasing hormone: distribution, role and importance].
Localization (releasing) of Thyrotropin-releasing hormone
13) Confidence 0.73 Published 1991 Journal Srp Arh Celok Lek Section Title Doc Link 1806996 Disease Relevance 0 Pain Relevance 0.25
Some patients (up to 50%) have an increase in their GH concentration after thyrotropin-releasing hormone (TRH) and/or gonadotropin-releasing hormone (GnRH) stimulation.
Localization (concentration) of thyrotropin-releasing hormone
14) Confidence 0.73 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459162 Disease Relevance 0.56 Pain Relevance 0.03
Serial sections were immunostained by antisera of 14 different neuropeptides--oxytocin, vasopressin, thyrotropin-releasing hormone, angiotensin II, calcitonin gene-related peptide, beta-endorphin, dynorphin A, dynorphin B, leucine-enkephalin, alpha-melanocyte stimulating hormone, substance P, neuropeptide Y, cholecystokinin and galanin--alternately.
Localization (releasing) of thyrotropin-releasing hormone in melanocyte associated with dynorphin, neuropeptide, enkephalin, cholecystokinin, substance p and calcitonin gene-related peptide
15) Confidence 0.73 Published 1992 Journal Neuroscience Section Abstract Doc Link 1542421 Disease Relevance 0 Pain Relevance 0.83
Neuropeptides like substance P, dynorphin A and B, cholecystokinin, galanin, corticotropin-releasing factor, thyrotropin-releasing hormone, angiotensin II and neurotensin showed no immunoreactivity in the human superior cervical ganglion.
Localization (releasing) of thyrotropin-releasing hormone in superior cervical ganglion associated with ganglion cysts, dynorphin, neuropeptide, cholecystokinin and substance p
16) Confidence 0.73 Published 1992 Journal Brain Res. Section Abstract Doc Link 1352173 Disease Relevance 0.41 Pain Relevance 0.59
Failure of growth hormone (hGH), cortisol and prolactin to respond to insulin induced hypoglycaemia (0.1 U/kg), of luteinizing hormone (LH) and follicle stimulating hormone (FSH) to respond to gonadotrophin releasing hormone (GnRH, 100 microgram) and of thyrotrophin (TSH) and prolactin to increase after thyrotrophin releasing hormone (TRH, 500 microgram), confirmed the diagnosis of panhypopituitarism.
Localization (releasing) of TRH in follicle associated with hypoglycemia and hypopituitarism
17) Confidence 0.73 Published 1978 Journal Acta Endocrinol. Section Abstract Doc Link 707005 Disease Relevance 0.95 Pain Relevance 0.07
The syndrome is characterized by: adipsia-hypodipsia (5/5 patients), recurrent hypernatremia (5/5), obesity (4/5), inability to excrete a water load (5/5), lack of growth hormone release in response to provocative stimuli (4/4), blunted thyrotropin releasing hormone responses (3/4), hypothyroidism (2/4), and hyperlipemia associated with hypernatremic crisis (1/1).
Neg (lack) Localization (excrete) of thyrotropin releasing hormone associated with syndrome, thyroid disease, obesity, hyperlipidemia and hypernatremia
18) Confidence 0.73 Published 1982 Journal Pediatrics Section Abstract Doc Link 6808452 Disease Relevance 0.85 Pain Relevance 0.09
Growth hormone secretion in anaesthetized fowl. 1.
Localization (secretion) of TRH associated with anesthesia
19) Confidence 0.71 Published 1985 Journal Gen. Comp. Endocrinol. Section Title Doc Link 3926599 Disease Relevance 0 Pain Relevance 0.10
Suppression of clonidine-induced release of growth hormone by thyrotropin releasing hormone in humans.
Localization (releasing) of thyrotropin releasing hormone associated with clonidine
20) Confidence 0.70 Published 1979 Journal J. Endocrinol. Invest. Section Title Doc Link 119798 Disease Relevance 0.09 Pain Relevance 0.39

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox